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Longevity

Mitochondrial HealthEvidence & Dosage

Biogenesis, mitophagy, MitoQ and PQQ strategies.

Studies last updated

Evidence at a glance

Total studies
593
With abstract
49
Meta / Systematic / RCT
77
Highly cited
50
Publication years
2007–2026

Mitochondrial Health in the context of Longevity

This topic is part of our "Longevity" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Mitochondrial Health

Ranked by influential-citation count and publication year.

  1. Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis.

    Mol Psychiatry2012n=112Meta-Analysis200 influential citations

    A comprehensive literature search was performed to collate evidence of mitochondrial dysfunction in autism spectrum disorders (ASDs) with two primary objectives. First, features of mitochondrial dysfunction in the general population of…

  2. Understanding the gut microbiota and sarcopenia: a systematic review.

    J Cachexia Sarcopenia Muscle2021n=26systematic200 influential citations

    BACKGROUND: Gut microbiota dysbiosis and sarcopenia commonly occur in the elderly. Although the concept of the gut-muscle axis has been raised, the casual relationship is still unclear. This systematic review analyses the current evidence…

  3. Biomarkers of mitochondrial dysfunction in autism spectrum disorder: A systematic review and meta-analysis.

    Neurobiol Dis2024n=204Meta-Analysis158 influential citations

    Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting 1 in 36 children and is associated with physiological abnormalities, most notably mitochondrial dysfunction, at least in a subset of individuals. This systematic…

    Finding: Thirteen controlled studies reported mitochondrial DNA deletions or variations in the ASD group across multiple tissues, including blood and brain.

  4. Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence.

    Nutrients2024n=15Systematic Review129 influential citations

    Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, and mitochondrial dysfunction. Curcumin, a natural compound with potent…

  5. Adipose Tissue Dysfunction in Polycystic Ovary Syndrome.

    J Clin Endocrinol Metab2023Systematic Review127 influential citations

    Purpose Polycystic ovary syndrome (PCOS) is a complex genetic trait and the most common endocrine disorder of women, clinically evident in 5% to 15% of reproductive-aged women globally, with associated cardiometabolic dysfunction. Adipose…

  6. Deregulated mitochondrial microRNAs in Alzheimer's disease: Focus on synapse and mitochondria.

    Ageing Res Rev2022Meta-Analysis121 influential citations

    Alzheimer's disease (AD) is the most common cause of dementia and is currently one of the biggest public health concerns in the world. Mitochondrial dysfunction in neurons is one of the major hallmarks of AD. Emerging evidence suggests…

    Finding: This review discusses how differences in mitochondrial miRNA expression may affect ATP production, oxidative stress, mitophagy, bioenergetics, mitochondrial dynamics, synaptic activity, synaptic plasticity, neurotransmission, and synaptotoxicity in neurons during Alzheimer's disease.

  7. Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle.

    Aging Cell2024n=317Meta-Analysis95 influential citations

    Exercise training prevents age-related decline in muscle function. Targeting epigenetic aging is a promising actionable mechanism and late-life exercise mitigates epigenetic aging in rodent muscle. Whether exercise training can decelerate,…

    Finding: Individuals with higher baseline aerobic fitness had younger epigenetic and transcriptomic profiles in human skeletal muscle.

  8. A systematic review of p53 regulation of oxidative stress in skeletal muscle.

    Redox Rep2018Systematic Review81 influential citations

    <h4>Background</h4>p53 is a tumor suppressor protein involved in regulating a wide array of signaling pathways. The role of p53 in the cell is determined by the type of imposed oxidative stress, its intensity and duration. The last decade…

  9. Complex I deficiency: clinical features, biochemistry and molecular genetics.

    J Med Genet2012n=172Systematic Review79 influential citations

    Complex I deficiency is the most frequent mitochondrial disorder presenting in childhood, accounting for up to 30% of cases. As with many mitochondrial disorders, complex I deficiency is characterised by marked clinical and genetic…

  10. Association of mitochondrial DNA levels with frailty and all-cause mortality.

    J Mol Med (Berl)2015n=16,401Meta-Analysis72 influential citations

    Mitochondrial function is altered with age and variants in mitochondrial DNA (mtDNA) modulate risk for several age-related disease states. However, the association of mtDNA copy number, a readily available marker which reflects…

    Finding: Lower mtDNA copy number was significantly associated with prevalent frailty in white participants from CHS.

Frequently asked

What dosage was studied?
• Mitochondrial dysfunction assessment; treatment studies in ASD/MD with carnitine, co-enzyme Q10, and B-vitamins (Not reported) • Gut microbiota-modulating interventions including probiotics, prebiotics, synbiotics, fermented milk, caloric restriction, exercise, SCFAs, fecal microbiota transplantation, antibiotics, dietary supplements, food withdrawal (Not reported in abstract) • Biomarkers of mitochondrial dysfunction in ASD; mitochondrial-targeted treatments discussed (carnitine, ubiquinol)
Are there safety considerations for Mitochondrial Health?
• Not reported • Not reported in abstract • Mitochondrial-targeted treatments such as carnitine and ubiquinol appeared beneficial. • The review did not report adverse events or dose ceilings for treatments.

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