Zurück zu Longevity
Longevity

Mitochondrial HealthStudienlage & Dosis

Biogenese, Mitophagie, MitoQ und PQQ-Strategien.

Studien zuletzt aktualisiert

Studienlage in Zahlen

Studien gesamt
593
Mit Abstract
49
Meta / Systematic / RCT
77
Häufig zitiert
50
Erscheinungsjahre
2007–2026

Mitochondrial Health im Kontext von Longevity

Dieses Thema ist Teil unserer Welt „Longevity". Dort findest du Methodik, Studienlage und Hebel mit dem größten Effekt — sowie die Reihenfolge, in der sich Hebel sinnvoll aufeinander aufbauen.

Zur Welt Longevity

Top-Studien zu Mitochondrial Health

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

  1. Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis.

    Mol Psychiatry2012n=112Meta-Analysis200 einflussreiche Zitationen

    A comprehensive literature search was performed to collate evidence of mitochondrial dysfunction in autism spectrum disorders (ASDs) with two primary objectives. First, features of mitochondrial dysfunction in the general population of…

  2. Understanding the gut microbiota and sarcopenia: a systematic review.

    J Cachexia Sarcopenia Muscle2021n=26systematic200 einflussreiche Zitationen

    BACKGROUND: Gut microbiota dysbiosis and sarcopenia commonly occur in the elderly. Although the concept of the gut-muscle axis has been raised, the casual relationship is still unclear. This systematic review analyses the current evidence…

  3. Biomarkers of mitochondrial dysfunction in autism spectrum disorder: A systematic review and meta-analysis.

    Neurobiol Dis2024n=204Meta-Analysis158 einflussreiche Zitationen

    Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting 1 in 36 children and is associated with physiological abnormalities, most notably mitochondrial dysfunction, at least in a subset of individuals. This systematic…

    Befund: Thirteen controlled studies reported mitochondrial DNA deletions or variations in the ASD group across multiple tissues, including blood and brain.

  4. Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence.

    Nutrients2024n=15Systematic Review129 einflussreiche Zitationen

    Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, and mitochondrial dysfunction. Curcumin, a natural compound with potent…

  5. Adipose Tissue Dysfunction in Polycystic Ovary Syndrome.

    J Clin Endocrinol Metab2023Systematic Review127 einflussreiche Zitationen

    Purpose Polycystic ovary syndrome (PCOS) is a complex genetic trait and the most common endocrine disorder of women, clinically evident in 5% to 15% of reproductive-aged women globally, with associated cardiometabolic dysfunction. Adipose…

  6. Deregulated mitochondrial microRNAs in Alzheimer's disease: Focus on synapse and mitochondria.

    Ageing Res Rev2022Meta-Analysis121 einflussreiche Zitationen

    Alzheimer's disease (AD) is the most common cause of dementia and is currently one of the biggest public health concerns in the world. Mitochondrial dysfunction in neurons is one of the major hallmarks of AD. Emerging evidence suggests…

    Befund: This review discusses how differences in mitochondrial miRNA expression may affect ATP production, oxidative stress, mitophagy, bioenergetics, mitochondrial dynamics, synaptic activity, synaptic plasticity, neurotransmission, and synaptotoxicity in neurons during Alzheimer's disease.

  7. Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle.

    Aging Cell2024n=317Meta-Analysis95 einflussreiche Zitationen

    Exercise training prevents age-related decline in muscle function. Targeting epigenetic aging is a promising actionable mechanism and late-life exercise mitigates epigenetic aging in rodent muscle. Whether exercise training can decelerate,…

    Befund: Individuals with higher baseline aerobic fitness had younger epigenetic and transcriptomic profiles in human skeletal muscle.

  8. A systematic review of p53 regulation of oxidative stress in skeletal muscle.

    Redox Rep2018Systematic Review81 einflussreiche Zitationen

    <h4>Background</h4>p53 is a tumor suppressor protein involved in regulating a wide array of signaling pathways. The role of p53 in the cell is determined by the type of imposed oxidative stress, its intensity and duration. The last decade…

  9. Complex I deficiency: clinical features, biochemistry and molecular genetics.

    J Med Genet2012n=172Systematic Review79 einflussreiche Zitationen

    Complex I deficiency is the most frequent mitochondrial disorder presenting in childhood, accounting for up to 30% of cases. As with many mitochondrial disorders, complex I deficiency is characterised by marked clinical and genetic…

  10. Association of mitochondrial DNA levels with frailty and all-cause mortality.

    J Mol Med (Berl)2015n=16.401Meta-Analysis72 einflussreiche Zitationen

    Mitochondrial function is altered with age and variants in mitochondrial DNA (mtDNA) modulate risk for several age-related disease states. However, the association of mtDNA copy number, a readily available marker which reflects…

    Befund: Lower mtDNA copy number was significantly associated with prevalent frailty in white participants from CHS.

Häufige Fragen

Welche Dosierung wurde in den Studien untersucht?
• Mitochondrial dysfunction assessment; treatment studies in ASD/MD with carnitine, co-enzyme Q10, and B-vitamins (Not reported) • Gut microbiota-modulating interventions including probiotics, prebiotics, synbiotics, fermented milk, caloric restriction, exercise, SCFAs, fecal microbiota transplantation, antibiotics, dietary supplements, food withdrawal (Not reported in abstract) • Biomarkers of mitochondrial dysfunction in ASD; mitochondrial-targeted treatments discussed (carnitine, ubiquinol)
Gibt es Sicherheitshinweise zu Mitochondrial Health?
• Not reported • Not reported in abstract • Mitochondrial-targeted treatments such as carnitine and ubiquinol appeared beneficial. • The review did not report adverse events or dose ceilings for treatments.

Weitere Themen in Longevity

Zone 2

Niedrig-intensives Cardio — mitochondriale Biogenese, Longevity-Basis.

Rapamycin

mTOR-Inhibition, Langlebigkeits-Studien, Off-Label-Dosierung und Sicherheit.

AMPK Activators

Berberin, Alpha-Liponsäure, energetic stress und Glukose-Modulation.

ApoB

Bessere kardiovaskuläre Risiko-Metrik als LDL-C — moderne Lipidologie.

Autophagie

Zellulärer Selbstabbau — Fasten, Sport, Spermidin als Trigger.

Berberin

Glukose, Lipide, AMPK und GI-Verträglichkeits-Daten.

Biologisches Alter

GrimAge, PhenoAge, DunedinPACE — was Epigenetik-Uhren messen.

Caloric Restriction

CR-Mimetika, Lebensspannen-Forschung und NHP-Studien.

Krebsfrüherkennung

Empfehlungen, Über-Diagnose, Galleri-Tests, Ganzkörper-MRT (kritisch).

Zelluläre Seneszenz

„Zombie-Zellen", SASP, Senolytika-Ansätze.

Kollagen

Haut, Gelenke, Sehnen — Evidenz pro Hydrolysat plus Vitamin C.

Demenz-Prävention

Lifestyle-Faktoren: Bewegung, Schlaf, Hörgesundheit, Vaskuläre Gesundheit.

DEXA-Knochendichte

DEXA-Scan für Knochen + Körperzusammensetzung — Verlauf wichtiger als Einzelwert.

Epigenetische Uhren

Horvath, GrimAge, PhenoAge — was sie messen und nicht messen.

Epigenetik

DNA-Methylierung, Histon-Modifikationen, Umwelteinflüsse auf Genexpression.

Exosomen

Zell-Kommunikation, regenerative Anwendungen, frühes Forschungsfeld.

Genetiktests

Variants, Pharmacogenomik, Limitationen — Methylierung, MTHFR-Mythen.

Glucosamine

Gelenke, UK Biobank Mortalitäts-Studie, Sulfat vs HCl-Formen.

Glycin

Methylierung, Kollagensynthese, Lebensspannen-Hinweise in Tiermodellen.

Griffkraft

Starker Mortalitäts-Prädiktor — einfach messbar, trainierbar.

Verwandte Themen aus anderen Welten

Mental

Natur

Forest Bathing, Grünflächen — Cortisol-Reduktion, Stimmungs-Effekte.

Mental

SAMe (S-Adenosylmethionin)

Methylierung, Depression und Leberunterstützung.

Mental

Sympathikus

Fight-or-Flight, Akut-Aktivierung, chronische Über-Aktivierung.

Peptide

CJC-1295

GHRH-Analog, Halbwertszeit-Varianten und Pulse-Patterns.

Peptide

Hexarelin

GH-Releaser, Toleranz-Aufbau schnell, kardiale Hinweise.

Peptide

LL-37

Antimikrobielles Peptid, Wundheilung, Immun-Modulation, frühe Forschung.