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Longevity

Caloric RestrictionStudienlage & Dosis

CR-Mimetika, Lebensspannen-Forschung und NHP-Studien.

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Studienlage in Zahlen

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1.000
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46
Meta / Systematic / RCT
145
Häufig zitiert
50
Erscheinungsjahre
1955–2026

Caloric Restriction im Kontext von Longevity

Dieses Thema ist Teil unserer Welt „Longevity". Dort findest du Methodik, Studienlage und Hebel mit dem größten Effekt — sowie die Reihenfolge, in der sich Hebel sinnvoll aufeinander aufbauen.

Zur Welt Longevity

Top-Studien zu Caloric Restriction

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

  1. Extended longevity in mice lacking the insulin receptor in adipose tissue.

    Science (New York, N.Y.)2003200 einflussreiche Zitationen

    Caloric restriction has been shown to increase longevity in organisms ranging from yeast to mammals. In some organisms, this has been associated with a decreased fat mass and alterations in insulin/insulin-like growth factor 1 (IGF-1)…

  2. The effectiveness and acceptability of Mediterranean diet and calorie restriction in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis.

    Clin Nutr2022n=303meta142 einflussreiche Zitationen

    BACKGROUND & AIMS: Lifestyle interventions that focus on reduced energy intake and improved dietary pattern are the mainstay of non-alcoholic fatty liver disease (NAFLD) management. However, it remains unclear which dietary approaches…

  3. A meta-analysis comparing the effectiveness of alternate day fasting, the 5:2 diet, and time-restricted eating for weight loss.

    Obesity (Silver Spring)2023n=176meta111 einflussreiche Zitationen

    OBJECTIVE: The objective of this meta-analysis was to compare the effectiveness of different intermittent fasting (IF) regimens on weight loss, in the general population, and compare these to traditional caloric energy restriction (CER).…

    Befund: In this meta-analysis of 24 RCTs, alternate day fasting ranked as the most effective regimen for weight loss, ahead of caloric energy restriction and time-restricted eating.

  4. A systematic review and meta-analysis on the effects of exercise training versus hypocaloric diet: distinct effects on body weight and visceral adipose tissue.

    Obes Rev2016n=4.815Meta-Analysis102 einflussreiche Zitationen

    Summary Exercise training (‘exercise’) and hypocaloric diet (‘diet’) are frequently prescribed for weight loss in obesity. Whilst body weight changes are commonly used to evaluate lifestyle interventions, visceral adiposity (VAT) is a more…

  5. Intermittent fasting strategies and their effects on body weight and other cardiometabolic risk factors: systematic review and network meta-analysis of randomised clinical trials.

    BMJ2025n=99Meta-Analysis102 einflussreiche Zitationen

    OBJECTIVE: To assess the effect of intermittent fasting diets, with continuous energy restriction or unrestricted (ad-libitum) diets on intermediate cardiometabolic outcomes from randomised clinical trials. DESIGN: Systematic review and…

    Befund: In this systematic review and network meta-analysis, all intermittent fasting and continuous energy restriction strategies reduced body weight compared with ad-libitum diets.

  6. Food Timing, Circadian Rhythm and Chrononutrition: A Systematic Review of Time-Restricted Eating's Effects on Human Health.

    Nutrients2020n=494Systematic Review97 einflussreiche Zitationen

    Introduction: Recent observations have shown that lengthening the daily eating period may contribute to the onset of chronic diseases. Time-restricted eating (TRE) is a diet that especially limits this daily food window. It could represent…

  7. Effects of Different Exercises Combined with Different Dietary Interventions on Body Composition: A Systematic Review and Network Meta-Analysis.

    Nutrients2024n=78Meta-Analysis71 einflussreiche Zitationen

    <h4>Background</h4>Exercise and dietary interventions are essential for maintaining weight and reducing fat accumulation. With the growing popularity of various dietary strategies, evidence suggests that combining exercise with dietary…

  8. Effect of Diet on Insulin Resistance in Polycystic Ovary Syndrome.

    J Clin Endocrinol Metab2020n=119meta66 einflussreiche Zitationen

    OBJECTIVE: The effect of diet on insulin resistance (IR) in polycystic ovary syndrome (PCOS) is controversial. Thus, we conducted this systematic review and meta-analysis to evaluate whether diet could reduce IR in women with PCOS while…

    Befund: Diet was significantly related to improvements in insulin resistance in women with polycystic ovary syndrome.

  9. Central obesity and the Mediterranean diet: A systematic review of intervention trials.

    Crit Rev Food Sci Nutr2018n=718systematic63 einflussreiche Zitationen

    Central obesity is associated with chronic low-grade inflammation, and is a risk factor for cardiometabolic syndrome. The Mediterranean diet pattern has a convincing evidence-base for improving cardiometabolic health. This review…

  10. Effect of Calorie Restriction and Intermittent Fasting Regimens on Brain-Derived Neurotrophic Factor Levels and Cognitive Function in Humans: A Systematic Review.

    Medicina (Kaunas)2024n=16Systematic Review63 einflussreiche Zitationen

    <i>Background:</i> The potential positive interaction between intermittent fasting (IF) and brain-derived neurotrophic factor (BDNF) on cognitive function has been widely discussed. This systematic review tried to assess the efficacy of…

Häufige Fragen

Welche Dosierung wurde in den Studien untersucht?
• Mediterranean diet, calorie restriction, and Mediterranean diet component interventions (Varied across included studies; calorie restriction dose-response relationship reported but exact amounts not provided in abstract) • very low calorie ketogenic diet (VLCKD) (not reported)
Für welche Population gilt die Evidenz?
Die meisten Studien untersuchten: patient; unknown.
Gibt es Sicherheitshinweise zu Caloric Restriction?
• No adverse events were reported in the abstract. • Discontinuation on VLCKD was 7.5%. • Serum sodium increased by +1.6 mEq/l during VLCKD. • No change in serum creatinine, uric acid, or potassium was reported.

Weitere Themen in Longevity

Zone 2

Niedrig-intensives Cardio — mitochondriale Biogenese, Longevity-Basis.

Rapamycin

mTOR-Inhibition, Langlebigkeits-Studien, Off-Label-Dosierung und Sicherheit.

AMPK Activators

Berberin, Alpha-Liponsäure, energetic stress und Glukose-Modulation.

ApoB

Bessere kardiovaskuläre Risiko-Metrik als LDL-C — moderne Lipidologie.

Autophagie

Zellulärer Selbstabbau — Fasten, Sport, Spermidin als Trigger.

Berberin

Glukose, Lipide, AMPK und GI-Verträglichkeits-Daten.

Biologisches Alter

GrimAge, PhenoAge, DunedinPACE — was Epigenetik-Uhren messen.

Krebsfrüherkennung

Empfehlungen, Über-Diagnose, Galleri-Tests, Ganzkörper-MRT (kritisch).

Zelluläre Seneszenz

„Zombie-Zellen", SASP, Senolytika-Ansätze.

Kollagen

Haut, Gelenke, Sehnen — Evidenz pro Hydrolysat plus Vitamin C.

Demenz-Prävention

Lifestyle-Faktoren: Bewegung, Schlaf, Hörgesundheit, Vaskuläre Gesundheit.

DEXA-Knochendichte

DEXA-Scan für Knochen + Körperzusammensetzung — Verlauf wichtiger als Einzelwert.

Epigenetische Uhren

Horvath, GrimAge, PhenoAge — was sie messen und nicht messen.

Epigenetik

DNA-Methylierung, Histon-Modifikationen, Umwelteinflüsse auf Genexpression.

Exosomen

Zell-Kommunikation, regenerative Anwendungen, frühes Forschungsfeld.

Genetiktests

Variants, Pharmacogenomik, Limitationen — Methylierung, MTHFR-Mythen.

Glucosamine

Gelenke, UK Biobank Mortalitäts-Studie, Sulfat vs HCl-Formen.

Glycin

Methylierung, Kollagensynthese, Lebensspannen-Hinweise in Tiermodellen.

Griffkraft

Starker Mortalitäts-Prädiktor — einfach messbar, trainierbar.

Hallmarks of Aging

Genomische Instabilität, Telomer-Verkürzung, epigenetische Veränderungen, etc.

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