Caloric RestrictionStudienlage & Dosis
CR-Mimetika, Lebensspannen-Forschung und NHP-Studien.
Studienlage in Zahlen
- Studien gesamt
- 1.000
- Mit Abstract
- 46
- Meta / Systematic / RCT
- 145
- Häufig zitiert
- 50
- Erscheinungsjahre
- 1955–2026
Caloric Restriction im Kontext von Longevity
Dieses Thema ist Teil unserer Welt „Longevity". Dort findest du Methodik, Studienlage und Hebel mit dem größten Effekt — sowie die Reihenfolge, in der sich Hebel sinnvoll aufeinander aufbauen.
Zur Welt LongevityTop-Studien zu Caloric Restriction
Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.
Extended longevity in mice lacking the insulin receptor in adipose tissue.
Science (New York, N.Y.)2003200 einflussreiche ZitationenCaloric restriction has been shown to increase longevity in organisms ranging from yeast to mammals. In some organisms, this has been associated with a decreased fat mass and alterations in insulin/insulin-like growth factor 1 (IGF-1)…
The effectiveness and acceptability of Mediterranean diet and calorie restriction in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis.
Clin Nutr2022n=303meta142 einflussreiche ZitationenBACKGROUND & AIMS: Lifestyle interventions that focus on reduced energy intake and improved dietary pattern are the mainstay of non-alcoholic fatty liver disease (NAFLD) management. However, it remains unclear which dietary approaches…
A meta-analysis comparing the effectiveness of alternate day fasting, the 5:2 diet, and time-restricted eating for weight loss.
Obesity (Silver Spring)2023n=176meta111 einflussreiche ZitationenOBJECTIVE: The objective of this meta-analysis was to compare the effectiveness of different intermittent fasting (IF) regimens on weight loss, in the general population, and compare these to traditional caloric energy restriction (CER).…
Befund: In this meta-analysis of 24 RCTs, alternate day fasting ranked as the most effective regimen for weight loss, ahead of caloric energy restriction and time-restricted eating.
A systematic review and meta-analysis on the effects of exercise training versus hypocaloric diet: distinct effects on body weight and visceral adipose tissue.
Obes Rev2016n=4.815Meta-Analysis102 einflussreiche ZitationenSummary Exercise training (‘exercise’) and hypocaloric diet (‘diet’) are frequently prescribed for weight loss in obesity. Whilst body weight changes are commonly used to evaluate lifestyle interventions, visceral adiposity (VAT) is a more…
Intermittent fasting strategies and their effects on body weight and other cardiometabolic risk factors: systematic review and network meta-analysis of randomised clinical trials.
BMJ2025n=99Meta-Analysis102 einflussreiche ZitationenOBJECTIVE: To assess the effect of intermittent fasting diets, with continuous energy restriction or unrestricted (ad-libitum) diets on intermediate cardiometabolic outcomes from randomised clinical trials. DESIGN: Systematic review and…
Befund: In this systematic review and network meta-analysis, all intermittent fasting and continuous energy restriction strategies reduced body weight compared with ad-libitum diets.
Food Timing, Circadian Rhythm and Chrononutrition: A Systematic Review of Time-Restricted Eating's Effects on Human Health.
Nutrients2020n=494Systematic Review97 einflussreiche ZitationenIntroduction: Recent observations have shown that lengthening the daily eating period may contribute to the onset of chronic diseases. Time-restricted eating (TRE) is a diet that especially limits this daily food window. It could represent…
Effects of Different Exercises Combined with Different Dietary Interventions on Body Composition: A Systematic Review and Network Meta-Analysis.
Nutrients2024n=78Meta-Analysis71 einflussreiche Zitationen<h4>Background</h4>Exercise and dietary interventions are essential for maintaining weight and reducing fat accumulation. With the growing popularity of various dietary strategies, evidence suggests that combining exercise with dietary…
Effect of Diet on Insulin Resistance in Polycystic Ovary Syndrome.
J Clin Endocrinol Metab2020n=119meta66 einflussreiche ZitationenOBJECTIVE: The effect of diet on insulin resistance (IR) in polycystic ovary syndrome (PCOS) is controversial. Thus, we conducted this systematic review and meta-analysis to evaluate whether diet could reduce IR in women with PCOS while…
Befund: Diet was significantly related to improvements in insulin resistance in women with polycystic ovary syndrome.
Central obesity and the Mediterranean diet: A systematic review of intervention trials.
Crit Rev Food Sci Nutr2018n=718systematic63 einflussreiche ZitationenCentral obesity is associated with chronic low-grade inflammation, and is a risk factor for cardiometabolic syndrome. The Mediterranean diet pattern has a convincing evidence-base for improving cardiometabolic health. This review…
Effect of Calorie Restriction and Intermittent Fasting Regimens on Brain-Derived Neurotrophic Factor Levels and Cognitive Function in Humans: A Systematic Review.
Medicina (Kaunas)2024n=16Systematic Review63 einflussreiche Zitationen<i>Background:</i> The potential positive interaction between intermittent fasting (IF) and brain-derived neurotrophic factor (BDNF) on cognitive function has been widely discussed. This systematic review tried to assess the efficacy of…
Häufige Fragen
Welche Dosierung wurde in den Studien untersucht?
Für welche Population gilt die Evidenz?
Gibt es Sicherheitshinweise zu Caloric Restriction?
Weitere Themen in Longevity
Zone 2
Niedrig-intensives Cardio — mitochondriale Biogenese, Longevity-Basis.
Rapamycin
mTOR-Inhibition, Langlebigkeits-Studien, Off-Label-Dosierung und Sicherheit.
AMPK Activators
Berberin, Alpha-Liponsäure, energetic stress und Glukose-Modulation.
ApoB
Bessere kardiovaskuläre Risiko-Metrik als LDL-C — moderne Lipidologie.
Autophagie
Zellulärer Selbstabbau — Fasten, Sport, Spermidin als Trigger.
Berberin
Glukose, Lipide, AMPK und GI-Verträglichkeits-Daten.
Biologisches Alter
GrimAge, PhenoAge, DunedinPACE — was Epigenetik-Uhren messen.
Krebsfrüherkennung
Empfehlungen, Über-Diagnose, Galleri-Tests, Ganzkörper-MRT (kritisch).
Zelluläre Seneszenz
„Zombie-Zellen", SASP, Senolytika-Ansätze.
Kollagen
Haut, Gelenke, Sehnen — Evidenz pro Hydrolysat plus Vitamin C.
Demenz-Prävention
Lifestyle-Faktoren: Bewegung, Schlaf, Hörgesundheit, Vaskuläre Gesundheit.
DEXA-Knochendichte
DEXA-Scan für Knochen + Körperzusammensetzung — Verlauf wichtiger als Einzelwert.
Epigenetische Uhren
Horvath, GrimAge, PhenoAge — was sie messen und nicht messen.
Epigenetik
DNA-Methylierung, Histon-Modifikationen, Umwelteinflüsse auf Genexpression.
Exosomen
Zell-Kommunikation, regenerative Anwendungen, frühes Forschungsfeld.
Genetiktests
Variants, Pharmacogenomik, Limitationen — Methylierung, MTHFR-Mythen.
Glucosamine
Gelenke, UK Biobank Mortalitäts-Studie, Sulfat vs HCl-Formen.
Glycin
Methylierung, Kollagensynthese, Lebensspannen-Hinweise in Tiermodellen.
Griffkraft
Starker Mortalitäts-Prädiktor — einfach messbar, trainierbar.
Hallmarks of Aging
Genomische Instabilität, Telomer-Verkürzung, epigenetische Veränderungen, etc.
Verwandte Themen aus anderen Welten
NEAT
Non-Exercise Activity Thermogenesis — unterschätzter Energieverbrauch.
Purpose
Ikigai, Eudaimonie — Longevity-relevanter Faktor.
Schichtarbeit
Circadiane Disruption, Krebsrisiko, Gegenmaßnahmen.
Vegan/Vegetarisch
Pflanzenbasiert — Stärken, Defizite (B12, Eisen, Omega-3), Strategien.
Burnout-Frühsymptome
Erschöpfung, Zynismus, Leistungsabfall — vor dem Zusammenbruch erkennen.
Doomscrolling
Algorithmus-getriebene negative Info-Aufnahme — Stimmungs-Effekte, Limits.