Longevity

Zelluläre SeneszenzStudienlage & Dosis

„Zombie-Zellen", SASP, Senolytika-Ansätze.

Studienlage in Zahlen

Studien gesamt: 1.000
Mit Abstract: 47
Meta / Systematic / RCT: 0
Häufig zitiert: 7
Erscheinungsjahre: 1961–2026

Zelluläre Seneszenz im Kontext von Longevity

Dieses Thema ist Teil unserer Welt „Longevity". Dort findest du Methodik, Studienlage und Hebel mit dem größten Effekt — sowie die Reihenfolge, in der sich Hebel sinnvoll aufeinander aufbauen.

Zur Welt Longevity

Top-Studien zu Zelluläre Seneszenz

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

Reversal of human cellular senescence: roles of the p53 and p16 pathways.
The EMBO journal2003194 einflussreiche Zitationen
Telomere erosion and subsequent dysfunction limits the proliferation of normal human cells by a process termed replicative senescence. Replicative senescence is thought to suppress tumorigenesis by establishing an essentially irreversible…
The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration.
Genes & development2017n=10165 einflussreiche Zitationen
Senescence is a form of cell cycle arrest induced by stress such as DNA damage and oncogenes. However, while arrested, senescent cells secrete a variety of proteins collectively known as the senescence-associated secretory phenotype…
Cellular senescence in aging primates.
Science (New York, N.Y.)2006164 einflussreiche Zitationen
The aging of organisms is characterized by a gradual functional decline of all organ systems. Mammalian somatic cells in culture display a limited proliferative life span, at the end of which they undergo an irreversible cell cycle arrest…
Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration.
Arthritis research & therapy2007101 einflussreiche Zitationen
Current evidence implicates intervertebral disc degeneration as a major cause of low back pain, although its pathogenesis is poorly understood. Numerous characteristic features of disc degeneration mimic those seen during ageing but appear…
Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin.
Aging2012n=966 einflussreiche Zitationen
Cellular senescence arrests the proliferation of mammalian cells at risk for neoplastic transformation, and is also associated with aging. However, the factors that cause cellular senescence during aging are unclear. Excessive reactive…
Cigarette smoke induces cellular senescence.
American journal of respiratory cell and molecular biology200648 einflussreiche Zitationen
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States, and cigarette smoking is the major risk factor for COPD. Fibroblasts play an important role in repair and lung homeostasis. Recent…
Update of cellular senescence in kidney fibrosis: from mechanism to potential interventions.
Front Med2025Review22 einflussreiche Zitationen
Kidney fibrosis is the final common pathway of virtually all chronic kidney disease (CKD). However, despite great progress in recent years, no targeted antifibrotic therapies have been approved. Epidemiologic, clinical, and molecular…
Cellular Senescence Drives Diabetic Atherosclerosis: Aging Mechanisms and Integrative Therapeutic Implications.
Aging and disease2026D
Cellular senescence is increasingly recognized as a key mechanism linking aging to chronic disease. Diabetic atherosclerosis (DAS), a major macrovascular complication of type 2 diabetes, often progresses despite standard metabolic and…
CK1-induced TERT phosphorylation mediates mitochondrial translocation to inhibit cardiomyocyte senescence and alleviate myocardial ischemia-reperfusion injury.
Cell biology and toxicology2026E
Cellular senescence is an outcome of mitochondrial dysfunction occurring during myocardial ischemia/reperfusion injury (MIRI). Mitochondrial telomerase reverse transcriptase (TERT) is responsible for cardiac protection and can improve…
Chronic Kidney Disease and Cellular Senescence.
2026
Chronic kidney disease (CKD) and kidney aging share many pathological and molecular features, with cellular senescence emerging as a potentially important contributor to disease progression. Senescent cells accumulate in the kidneys due to…