Sympathetic NSEvidence & Dosage
Fight-or-flight, acute activation, chronic over-activation.
Evidence at a glance
- Total studies
- 236
- With abstract
- 50
- Meta / Systematic / RCT
- 1
- Highly cited
- 50
- Publication years
- 1977–2026
Sympathetic NS in the context of Mental
This topic is part of our "Mental" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to MentalTop studies on Sympathetic NS
Ranked by influential-citation count and publication year.
Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans.
The Journal of clinical investigation1991200 influential citationsHyperinsulinemia may contribute to hypertension by increasing sympathetic activity and vascular resistance. We sought to determine if insulin increases central sympathetic neural outflow and vascular resistance in humans. We recorded…
Sympathetic overactivity in patients with chronic renal failure.
The New England journal of medicine1992n=18200 influential citations<h4>Background</h4>Hypertension is a frequent complication of chronic renal failure, but its causes are not fully understood. There is indirect evidence that increased activity of the sympathetic nervous system might contribute to…
Direct evidence from intraneural recordings for increased central sympathetic outflow in patients with heart failure.
Circulation1986n=16200 influential citationsPatients with heart failure have increased vascular resistance and evidence for increased neurohumoral drive. High levels of circulating norepinephrine are found in patients with heart failure, but it is not known whether they reflect…
Painful neuropathy: altered central processing maintained dynamically by peripheral input.
Pain1992200 influential citationsWe performed sensory assessments before and during diagnostic tourniquet-cuff and local anesthetic blocks in 4 patients diagnosed with reflex sympathetic dystrophy (RSD). All patients complained of mechano-allodynia; lightly touching the…
Elevated sympathetic nerve activity in borderline hypertensive humans. Evidence from direct intraneural recordings.
Hypertension (Dallas, Tex. : 1979)1989200 influential citationsReports of elevated plasma catecholamine levels and augmented responses to autonomic blockade suggest increased sympathetic tone in borderline hypertension. It is not known if this reflects greater sympathetic neural outflow. We directly…
The sympathetic nervous system alterations in human hypertension.
Circulation research2015183 influential citationsSeveral articles have dealt with the importance and mechanisms of the sympathetic nervous system alterations in experimental animal models of hypertension. This review addresses the role of the sympathetic nervous system in the…
Sympathetic nervous system overactivity and its role in the development of cardiovascular disease.
Physiological reviews2010167 influential citationsThis review examines how the sympathetic nervous system plays a major role in the regulation of cardiovascular function over multiple time scales. This is achieved through differential regulation of sympathetic outflow to a variety of…
Cardiovascular consequences of loss of supraspinal control of the sympathetic nervous system after spinal cord injury.
Archives of physical medicine and rehabilitation2000156 influential citationsSpinal cord injury (SCI) with resultant quadriplegia or high paraplegia is associated with significant dysfunction of the sympathetic nervous system. This alteration of sympathetic nervous system activity occurs as a consequence of loss of…
Sympathetic nervous system activation in human heart failure: clinical implications of an updated model.
Journal of the American College of Cardiology2009127 influential citationsDisturbances in cardiovascular neural regulation, influencing both disease course and survival, progress as heart failure worsens. Heart failure due to left ventricular systolic dysfunction has long been considered a state of generalized…
How to assess sympathetic activity in humans.
Journal of hypertension1999117 influential citationsSympathetic factors play a central role not only in cardiovascular homeostatic control but also in the pathogenesis and/or in the progression of several cardiovascular diseases, such as essential hypertension, myocardial infarction,…
More topics in Mental
5-HTP
Serotonin precursor, mood, and Carbidopa safety.
Anxiety
Acute anxiety vs. an anxiety disorder, the neurobiology, interventions.
Ashwagandha (Stress)
Adaptogen — cortisol lowering, sleep, anxiety reduction.
Breathwork
Box breathing, 4-7-8, Wim Hof, pranayama — autonomic regulation.
Burnout Early Signs
Exhaustion, cynicism, dropping performance — spotting it before the crash.
Caffeine & Anxiety
Adenosine antagonism, individual sensitivity, cut-off strategies.
CBT
Cognitive behavioral therapy — the gold standard for anxiety and depression.
Co-Regulation
Nervous-system regulation within relationship — attachment, therapy, parent-child.
Cold Exposure (Mood)
Norepinephrine, depression, and mood effects of cold.
Depression
Symptoms, the monoamine hypothesis, lifestyle interventions, professional help.
Depth Psychology
Psychodynamic therapy, transference, long-term change.
Doomscrolling
Algorithm-driven negative info consumption — mood effects, limits.
EMDR / Trauma Therapy
PTSD, eye movements, and study effectiveness.
Exercise as Antidepressant
Aerobic exercise — efficacy comparable to SSRIs in mild depression.
Fight/Flight/Freeze
Stress-response patterns, somatic manifestation, regulation.
Glucose & Mood
Glucose swings, reactive hypoglycemia, mood stability.
Gut-Brain Axis
Vagus nerve, short-chain fatty acids, the microbiome's influence on mood.
Journaling (Mental)
Expressive writing, gratitude — reducing stress, anxiety and depression.
L-Tryptophan
Serotonin/Melatonin, amino‑acid competition and outcomes.
Lavender
Silexan studies, oral and olfactory — anxiolysis with a good safety profile.
Related topics from other worlds
Peptide Half-Life
Fast-acting vs. depot peptides — dosing and timing implications.
Semaglutide
GLP‑1 agonist, weight loss, diabetes outcomes, and long‑term safety.
Topical Peptides
Argireline, Matrixyl, GHK-Cu — anti-aging cosmetics with real evidence.
Carbohydrate Periodization
Train‑Low, Glycogen Adaptation, and Performance Outcomes.
EMS Training
Electrical muscle stimulation — marketing vs. actual effect sizes.
Lactate
Fuel, not a waste product — modern lactate research.