Peptide Half-LifeEvidence & Dosage
Fast-acting vs. depot peptides — dosing and timing implications.
Evidence at a glance
- Total studies
- 80
- With abstract
- 43
- Meta / Systematic / RCT
- 0
- Highly cited
- 5
- Publication years
- 2006–2026
Peptide Half-Life in the context of Peptides
This topic is part of our "Peptides" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to PeptidesTop studies on Peptide Half-Life
Ranked by influential-citation count and publication year.
Strategies to improve plasma half life time of peptide and protein drugs.
Amino acids2006122 influential citationsDue to the obvious advantages of long-acting peptide and protein drugs, strategies to prolong plasma half life time of such compounds are highly on demand. Short plasma half life times are commonly due to fast renal clearance as well as to…
Engineering and characterization of the long-acting glucagon-like peptide-1 analogue LY2189265, an Fc fusion protein.
Diabetes/metabolism research and reviews201059 influential citations<h4>Background</h4>Glucagon-like peptide-1 (GLP-1) receptor agonists are novel agents for type 2 diabetes treatment, offering glucose-dependent insulinotropic effects, reduced glucagonemia and a neutral bodyweight or weight-reducing…
Antimicrobial Peptides of the Cathelicidin Family: Focus on LL-37 and Its Modifications.
International journal of molecular sciences202538 influential citationsCathelicidins are a family of antimicrobial peptides (AMPs) with broad-spectrum activity and immunomodulatory functions. Among them, the only human cathelicidin LL-37 has garnered significant interest due to its potent antimicrobial,…
Enhanced plasma half-life and efficacy of engineered human albumin-fused GLP-1 despite enzymatic cleavage of its C-terminal end.
Communications biology202531 influential citationsAlbumin has a long plasma half-life due to engagement of the neonatal Fc receptor (FcRn), which prevents intracellular degradation. However, its C-terminal end can be cleaved by carboxypeptidase A, and removal of the last leucine residue…
Development of Petrelintide: a Potent, Stable, Long-Acting Human Amylin Analogue.
Journal of medicinal chemistry202528 influential citationsThe past few years have seen the approval of several medications for weight management, but there is an increasing need for new therapies that target different pathways of energy balance. Owing to its role as a physiological satiety signal…
Absorption, distribution, metabolism, and excretion of an antiviral drug-Fc conjugate CD388 following subcutaneous administration of 14 C-CD388 in the rat.
Drug metabolism and disposition: the biological fate of chemicals20252 influential citationsCD388 is a novel drug-Fc conjugate designed to function as a long-acting antiviral drug by inhibiting proliferation of the influenza virus. This action results from a dimeric form of zanamivir, a neuraminidase inhibitor, conjugated to an…
Preclinical Safety of APG777, A Novel Extended Half-Life Anti-Interleukin-13 Monoclonal Antibody, in Cynomolgus Monkeys.
International journal of toxicology20252 influential citationsInterleukin-13 (IL-13) is a cytokine implicated in the pathophysiology of type 2 inflammatory diseases and is a clinically validated target in atopic dermatitis. APG777 is a humanized IgG1 monoclonal antibody with an optimized…
Half-life extension of therapeutics: Applications and mechanisms.
The Journal of pharmacology and experimental therapeutics20252 influential citationsThe clinical effectiveness of peptide and protein therapeutics is often limited by their short circulating half-life, necessitating frequent injections. Therefore, half-life extension strategies have emerged as centerpieces in…
First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASP1617, a Cathepsin-S Inhibitor, in Healthy Adult Subjects.
Clinical and translational science20261 influential citationsASP1617 is a novel, highly selective inhibitor of cathepsin-S, an important protease for antigen peptide loading onto major histocompatibility complex class II molecules. Preclinically, ASP1617 prevented progression of lupus-like…
Interleukin-18 (IL-18) engineered for half-life extension and resistance to IL-18 binding protein (IL-18BP) to enhance anti-cancer therapeutic potential.
Cytokine20251 influential citationsRecombinant interleukin-18 (IL-18) holds promise as a therapeutic for oncology, as a robust activator of adaptive and innate immune cells and a potent producer of IFN-γ. However, clinical success has been limited due to rapid upregulation…
More topics in Peptides
Peptides Overview
Peptides, BPC-157, TB-500, safety and the state of the evidence.
Administration Routes
Subcutaneous, intramuscular, nasal, oral, topical — bioavailability and safety.
Autoimmunity Risk
Immune modulation can both promote tolerance and tip into dysregulation.
BPC-157
Peptide for tissue regeneration, healing, and athletic recovery.
Cerebrolysin
A pig-brain peptide mix, stroke studies, not approved in Germany.
CJC-1295
GHRH analog, half‑life variants and pulse patterns.
Dihexa
Angiotensin derivative, cognitive/neuroplasticity signals in animal models.
GHK-Cu
Copper peptide for skin health, anti-aging, and wound healing.
GHRP-2
GH releaser, older generation, appetite stimulation as a side effect.
GHRP-6
GH releaser with a strong appetite component.
GLP-1 Rebound
Weight regain after stopping without lifestyle anchors.
GLP-1 Side Effects
Nausea, gastric emptying, muscle loss, pancreatitis risk.
Hexarelin
GH releaser, fast tolerance build-up, cardiac signals.
IGF-1 LR3
Modified IGF-1 with a long half-life — hypertrophy, the cancer-risk debate.
Immune Modulation
Automatisch via Trend Scout entdeckt. Supplements targeting inflammation and immune resilience remain a central research area.. PubMed: 11956 Ergebnisse.
Injection Safety
Sterile technique, bacteriostatic water, skin disinfection — a medical topic.
Ipamorelin
Selective GH releaser, cortisol‑sparing, and stack combinations.
KPV
An alpha-MSH fragment — anti-inflammatory, gut, skin, early research.
Liraglutide
First-generation GLP-1 for diabetes/obesity — daily, smaller effect size.
LL-37
Antimicrobial peptide, wound healing, immune modulation, early research.
Related topics from other worlds
Hormonal System
Endocrine glands, hormone axes, feedback loops — how hormones steer behavior and metabolism.
LH & FSH
Pituitary hormones — they drive the testes and ovaries.
Pregnenolone
Hormone precursor, memory, steroid cascade and safety.
Testosterone
Testosterone optimization for energy, libido, muscle building, and vitality.
Acetylcholine
Memory, attention, REM sleep, choline sources.
Caffeine
Adenosine-receptor antagonist, tolerance, timing, half-life, genetics.