TestosteroneEvidence & Dosage
Testosterone optimization for energy, libido, muscle building, and vitality.
Evidence at a glance
- Total studies
- 1,000
- With abstract
- 50
- Meta / Systematic / RCT
- 89
- Highly cited
- 42
- Publication years
- 1959–2026
Testosterone in the context of Hormones
This topic is part of our "Hormones" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to HormonesTop studies on Testosterone
Ranked by influential-citation count and publication year.
The regulation of spermatogenesis by androgens.
Semin Cell Dev Biol2014Review200 influential citationsTestosterone is essential for maintaining spermatogenesis and male fertility. However, the molecular mechanisms by which testosterone acts have not begun to be revealed until recently. With the advances obtained from the use of transgenic…
Associations of Testosterone and Related Hormones With All-Cause and Cardiovascular Mortality and Incident Cardiovascular Disease in Men : Individual Participant Data Meta-analyses.
Ann Intern Med2024n=24,109Meta-Analysis141 influential citations<h4>Background</h4>Whether circulating sex hormones modulate mortality and cardiovascular disease (CVD) risk in aging men is controversial.<h4>Purpose</h4>To clarify associations of sex hormones with these outcomes.<h4>Data…
Testosterone physiology in resistance exercise and training: the up-stream regulatory elements.
Sports Med2010review114 influential citationsTestosterone is one of the most potent naturally secreted androgenic-anabolic hormones, and its biological effects include promotion of muscle growth. In muscle, testosterone stimulates protein synthesis (anabolic effect) and inhibits…
Gonadotropins for pubertal induction in males with hypogonadotropic hypogonadism: systematic review and meta-analysis.
Eur J Endocrinol2024n=532Meta-Analysis87 influential citations<h4>Objective</h4>Hypogonadotropic hypogonadism is characterized by inadequate secretion of pituitary gonadotropins, leading to absent, partial, or arrested puberty. In males, classical treatment with testosterone promotes virilization but…
Testosterone in women--the clinical significance.
Lancet Diabetes Endocrinol2015Review84 influential citationsTestosterone is an essential hormone for women, with physiological actions mediated directly or via aromatisation to oestradiol throughout the body. Despite the crucial role of testosterone and the high circulating concentrations of this…
Gonads under stress: A systematic review and meta-analysis on the effects of acute psychosocial stress on gonadal steroids secretion in humans.
Psychoneuroendocrinology2024n=881Meta-Analysis76 influential citationsAnimal research has shown that the hypothalamus-pituitary-gonadal (HPG) axis is inhibited by (chronic and/or severe) stress, which can lead to impaired fertility and reproductive functioning, presumably caused by the inhibition of gonadal…
Finding: Both the literature review and the quantitative meta-analysis suggested that acute stress stimulates rather than inhibits HPG axis activity in humans.
Human chorionic gonadotropin-based clinical treatments for infertile men with non-obstructive azoospermia.
Andrology2026Review70 influential citationsSpermatogenesis is primarily controlled by follicle-stimulating hormone and luteinizing hormone-driven testosterone. Luteinizing hormone acts on the Leydig cells, stimulating steroid production, predominantly testosterone, and activating…
Testosterone replacement in men with sexual dysfunction.
Cochrane Database Syst Rev2024n=11,419Systematic Review62 influential citations<h4>Background</h4>Clinical practice guidelines recommend testosterone replacement therapy (TRT) for men with sexual dysfunction and testosterone deficiency. However, TRT is commonly promoted in men without testosterone deficiency and…
Correlation between serum zinc and testosterone: A systematic review.
J Trace Elem Med Biol2023n=38Systematic Review51 influential citationsZinc is a vital trace element for normal function of the living system. In male, zinc is involved in various biological processes, an important function of which is as a balancer of hormones such as testosterone. For this purpose, studies…
Association between testosterone replacement therapy and cardiovascular outcomes: A meta-analysis of 30 randomized controlled trials.
Prog Cardiovasc Dis2024n=11,502Meta-Analysis42 influential citations<h4>Background</h4>The Cardiovascular safety of testosterone replacement therapy (TRT) among men with hypogonadism is not well established to date. Hence, we sought to evaluate the cardiovascular disease (CVD) outcomes among patients…
Frequently asked
What dosage was studied?
Are there safety considerations for Testosterone?
Related articles
Optimize Your Testosterone Levels - Important Tips and Studies
To optimize your testosterone levels, you should focus on a balanced diet, regular exercise, and sufficient sleep. Studies show that these factors can positively influence the testosterone level.
Ashwagandha: What Cortisol, Testosterone, and Sleep Really Say
Ashwagandha can lower stress markers and slightly improve sleep; a testosterone effect is possible, but not established. Liver risks are relevant.
More topics in Hormones
Adrenal Fatigue
A contested concept — what the evidence shows vs. how it's marketed.
Adrenal Glands
Cortisol, DHEA, adrenaline — the stress response and daily rhythm.
Adrenaline & Noradrenaline
Acute stress response, sympathetic nervous system, attention and reaction.
Chronic Stress
Allostatic load, immune and metabolic consequences, interventions.
Cortisol Daily Profile
The diurnal rhythm, CAR (cortisol awakening response), saliva measurement.
Cortisol Management
HPA axis, stress curve, adaptogens, and a healthy daily rhythm.
Cravings
Causes: blood-sugar swings, sleep deprivation, emotional eating.
Cycle Phases
Follicular phase, ovulation, luteal phase — adapting training and nutrition.
DHEA
DHEA as a precursor hormone for hormonal balance and vitality.
DHT
The most potent androgen metabolite — hair loss, prostate, libido.
Endometriosis
A chronic inflammatory disease — diagnosis, options, lifestyle factors.
Estrogen Balance
Women's optimization, aromatase, phytoestrogens, and menopause.
Free Testosterone
Bioavailable testosterone, SHBG's influence, clinical relevance.
fT3 & fT4
Free thyroid hormones — peripheral conversion and activity.
Ghrelin
Hunger hormone, sleep's influence, intermittent-fasting adaptation.
GLP-1
Glucagon-like peptide 1 — incretin, satiety, blood sugar, semaglutide's mechanism.
Growth Hormone (GH/IGF-1)
Sleep secretion, secretagogues and IGF-1 as biomarker
Hashimoto Thyroiditis
Autoimmune thyroid disease — TPO/TG antibodies, selenium, iodine caution.
Hormonal Contraception
The pill, IUD, risk profiles, side effects, alternatives.
Hormonal System
Endocrine glands, hormone axes, feedback loops — how hormones steer behavior and metabolism.
Related topics from other worlds
Ginger
6-gingerol, nausea, anti-inflammatory, relevance for sport.
Overtraining
Early warning signs, diagnosis, recovery strategies, hormone markers.
Stretching
Static vs. dynamic — timing, effects on performance and injury.
Alcohol & Sleep
Faster sleep onset, but REM suppression and night-time waking.
Benzodiazepines
Sedative/hypnotic — dependence, cognitive risks in older age.
CPAP
Continuous positive airway pressure — the standard for moderate apnea.