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Hormones

Hormonal ContraceptionEvidence & Dosage

The pill, IUD, risk profiles, side effects, alternatives.

Evidence at a glance

Total studies
468
With abstract
47
Meta / Systematic / RCT
1
Highly cited
4
Publication years
1981–2026

Hormonal Contraception in the context of Hormones

This topic is part of our "Hormones" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Hormonal Contraception

Ranked by influential-citation count and publication year.

  1. Oral contraceptive discontinuation: a prospective evaluation of frequency and reasons.

    American journal of obstetrics and gynecology1998n=1,657131 influential citations

    <h4>Objectives</h4>Our purpose was to define the frequency and reasons for oral contraceptive discontinuation and subsequent contraceptive behavior.<h4>Study design</h4>A nationwide prospective study of 1657 women initiating or switching…

  2. Menstrual cycle and hormonal contraceptive use modulate human brain structure.

    Brain research2010n=1453 influential citations

    Sex differences in human brain structure have repeatedly been described, but results are inconsistent. However, these studies hardly controlled for cycle phase of women or the use of hormonal contraceptives. Our study shows that these…

  3. Combined nestorone-testosterone gel suppresses serum gonadotropins to concentrations associated with effective hormonal contraception in men.

    Andrology2019n=44rct26 influential citations

    BACKGROUND: Novel male-based contraceptives are needed to broaden family planning choices. A progestin, Nestorone&#xae; (Nes) gel, plus a testosterone (T) gel suppresses sperm concentrations to levels associated with effective…

  4. 50 years of hormonal contraception-time to find out, what it does to our brain.

    Frontiers in neuroscience20149 influential citations

    Hormonal contraceptives are on the market for more than 50 years and used by 100 million women worldwide. However, while endogenous steroids have been convincingly associated with change in brain structure, function and cognitive…

  5. Safety of hormonal contraception among women with liver disease: an updated systematic review.

    Contraception20254 influential citations

    <h4>Objectives</h4>We sought to assess whether, among women with liver disease, there is an increased risk of adverse health effects with the use of hormonal contraception (HC).<h4>Study design</h4>We conducted a systematic review of six…

  6. Use of period- or fertility-tracking technologies pre- and post-Dobbs

    Contraception20263 influential citations

    <h4>Objectives</h4>This study aimed to evaluate whether the use of period- or fertility-tracking technologies decreased from pre- to post-Dobbs and to identify user characteristics and changes in reasons for use.<h4>Study design</h4>We…

  7. Consensus conference results on contraception in women beyond 40 years of age.

    The European journal of contraception &amp; reproductive health care : the official journal of the European Society of Contraception20253 influential citations

    <b>Objective:</b> The objective is to develop expert consensus to inform clinical decision-making in the use of hormonal contraceptives in women over 40 years of age. <b>Methods:</b> A multidisciplinary panel organised by the Italian…

  8. Safety of hormonal contraception among women with sickle cell disease: An updated systematic review.

    Contraception2025n=843 influential citations

    <h4>Objective</h4>To update a previous systematic review on sickle cell disease (SCD) and adverse health outcomes associated with hormonal contraception (HC) use.<h4>Study design</h4>We searched multiple databases for articles from…

  9. Parental influences on contraceptive autonomy among adolescents in the Southern USA.

    Culture, health &amp; sexuality20262 influential citations

    Research on contraceptive coercion among adolescent and young adult women in the USA focuses primarily on clinicians and male sexual partners. Less recognised is how parents may limit their daughters' autonomy to decide when and if to…

  10. Update on long- and short-acting contraceptive methods.

    Australian prescriber20252 influential citations

    Long-acting reversible contraceptive methods, including the contraceptive implant and intrauterine devices, are highly effective and cost-effective options for women who have no specific contraindications. Long-acting reversible…

Frequently asked

What dosage was studied?
• Combined nestorone-testosterone gel (Nes-T) (8.3 mg nestorone + 62.5 mg testosterone daily)
Which population does the evidence apply to?
Most studies investigated: healthy.
Are there safety considerations for Hormonal Contraception?
• No serious adverse events were reported. • Daily application of two hormone gels was simplified into one combined gel.

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