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Estrogen BalanceEvidence & Dosage

Women's optimization, aromatase, phytoestrogens, and menopause.

Studies last updated

Evidence at a glance

Total studies
755
With abstract
50
Meta / Systematic / RCT
121
Highly cited
50
Publication years
1986–2026

Estrogen Balance in the context of Hormones

This topic is part of our "Hormones" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Estrogen Balance

Ranked by influential-citation count and publication year.

  1. Estrogen Deficiency and the Origin of Obesity during Menopause.

    Biomed Res Int2014Systematic Review151 influential citations

    Sex hormones strongly influence body fat distribution and adipocyte differentiation. Estrogens and testosterone differentially affect adipocyte physiology, but the importance of estrogens in the development of metabolic diseases during…

  2. Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen.

    J Clin Oncol2010n=18,871Meta-Analysis149 influential citations

    <h4>Purpose</h4>To conduct meta-analyses of randomized trials of aromatase inhibitors (AIs) compared with tamoxifen either as initial monotherapy (cohort 1) or after 2 to 3 years of tamoxifen (cohort 2).<h4>Materials and methods</h4>Data…

    Finding: In cohort 1, the reduction in breast cancer mortality with aromatase inhibitors versus tamoxifen was not statistically significant.

  3. Factors influencing five-year adherence to adjuvant endocrine therapy in breast cancer patients: A systematic review.

    Breast2022n=26Systematic Review123 influential citations

    <h4>Purpose</h4>This systematic review aimed to determine the rate and identify correlates of adherence and persistence over five years of treatment with adjuvant endocrine therapy in female breast cancer patients.<h4>Methods</h4>Relevant…

  4. Neoadjuvant Endocrine Therapy for Estrogen Receptor-Positive Breast Cancer: A Systematic Review and Meta-analysis.

    JAMA Oncol2016n=349Meta-Analysis98 influential citations

    <h4>Importance</h4>Estrogen receptor-positive (ER+) tumors of the breast are generally highly responsive to endocrine treatment. Although endocrine therapy is the mainstay of adjuvant treatment for ER+ breast cancer, the role of endocrine…

  5. Is the oocyte quality affected by endometriosis? A review of the literature.

    J Ovarian Res2017n=4,383Meta-Analysis93 influential citations

    Endometriosis is an estrogen-dependent chronic inflammatory condition that affects women in their reproductive period causing infertility and pelvic pain. The disease, especially at the ovarian site has been shown to have a detrimental…

  6. The role of estrogen in female skeletal muscle aging: A systematic review.

    Maturitas2023n=32Systematic Review82 influential citations

    Aging is associated with a loss of skeletal muscle mass and function that negatively impacts the independence and quality of life of older individuals. Females demonstrate a distinct pattern of muscle aging compared to males, potentially…

  7. Adjuvant Endocrine Therapy for Women With Hormone Receptor-Positive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update on Ovarian Suppression.

    J Clin Oncol2016Systematic Review79 influential citations

    Purpose To update the ASCO adjuvant endocrine therapy guideline based on emerging data concerning the benefits and risks of ovarian suppression in addition to standard adjuvant therapy in premenopausal women with estrogen receptor–positive…

  8. Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure.

    Hum Reprod Update2020Systematic Review75 influential citations

    BACKGROUND Despite intense research, it remains intriguing why hormonal therapies in general and progestins in particular sometimes fail in endometriosis. OBJECTIVE AND RATIONALE We review here the action mechanisms of progesterone…

  9. Testosterone supplementation and bone parameters: a systematic review and meta-analysis study.

    J Endocrinol Invest2022n=310Meta-Analysis60 influential citations

    <h4>Background</h4>The role of testosterone (T) replacement therapy (TRT) in subjects with late onset hypogonadism is still the object of an intense debate.<h4>Methods</h4>All observational studies and placebo-controlled or -uncontrolled…

    Finding: Testosterone replacement therapy was associated with a significant reduction of bone resorption markers in observational studies but not in controlled studies.

  10. Anti-estrogen Treatment in Endometrial Cancer: A Systematic Review.

    Front Oncol2019n=16Systematic Review44 influential citations

    <b>Introduction:</b> Hormonal therapy in endometrial cancer (EC) is used for patients who wish to preserve fertility and for patients with advanced or recurrent disease in a palliative setting. First line hormonal therapy consists of…

Frequently asked

What dosage was studied?
• Estrogen deficiency / estrogen-related mechanisms (Not reported) • Aromatase inhibitors (AIs) (Not reported) • Adjuvant endocrine therapy
Are there safety considerations for Estrogen Balance?
• None reported in the abstract. • No indication of increased nonbreast deaths with aromatase inhibitors in either cohort. • Adverse effects were linked to lower adherence. • NET had lower toxicity than combination chemotherapy.

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