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Longevity

Stem CellsEvidence & Dosage

Clinical applications, hype, off-label risks abroad.

Evidence at a glance

Total studies
342
With abstract
46
Meta / Systematic / RCT
0
Highly cited
1
Publication years
1999–2026

Stem Cells in the context of Longevity

This topic is part of our "Longevity" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Stem Cells

Ranked by influential-citation count and publication year.

  1. Cancer stem cells and their vascular niche: Do they benefit from each other?

    Cancer Lett2016Review9 influential citations

    Cancer stem cells (CSCs) locate in and interact with particular vascular niches to maintain their stemness. CSCs induce, remodel and participate in the formation of microenvironmental niches to facilitate survival, stemness and escape from…

  2. Immune cells adapt to distinct stem cell niches to govern tissue homeostasis

    bioRxiv20261 influential citations

    Summary Paragraph In adult tissues, epithelial stem cells exist within distinct residences, each endowing them with exclusive instructions for regenerative fitness under homeostasis and stress. Key components of these ‘niches’ are immune…

  3. Immunotherapy and postoperative bone defect repair strategies based on osteosarcoma tumor microenvironment characteristics: balancing antitumor effects and promotion of bone regeneration.

    Regenerative biomaterials2026

    Advances in orthopedic biomaterials have significantly improved the bone regeneration domain; however, postoperative bone defect repair after bone tumor resection—particularly for osteosarcoma, a common primary malignant bone tumor in…

  4. NOTCH3 signal activation by its extracellular domain accumulation in an iPSC line newly established from a CADASIL patient.

    Human cell2026E

    Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic cerebral small-vessel disease caused by NOTCH3 mutations, yet its pathogenic mechanisms remain incompletely…

  5. The progress of mitochondrial function and transfer in stem cell regulation and therapy.

    Journal of physiology and biochemistry2026n=6D

    Mitochondria, serving as central organelles for energy metabolism, play a critical regulatory role in stem cell self-renewal and differentiation-a function increasingly supported by accumulating evidence and closely linked to various…

  6. Photobiomodulation-induced Differentiation of Adipose-derived Stem Cells into Neuronal Organoid-like Structures.

    Molecular neurobiology2026E

    The ability to regulate stem cell differentiation into organized neural tissue remains a major challenge in regenerative medicine, particularly in the development of physiologically relevant three-dimensional (3D) organoid models.…

  7. Aspirin-induced mesenchymal stem cell-derived extracellular vesicles promote osteochondral regeneration by reprogramming macrophages

    Biomaterials2026

    Persistent inflammatory responses in osteochondral defects produce a hostile microenvironment that severely compromises endogenous tissue repair mechanisms. The local immune microenvironment needs to be modulated to facilitate tissue…

  8. Artificial human stem cell niche created in cartilage-inspired hydrogel for enhanced articular cartilage regeneration

    Biomaterials2026

    Stem cell-based therapies and liposome-integrated hydrogel matrix strategies are promising for articular cartilage regeneration. However, challenges persist due to the loss of stemness during in vitro expansion and the lack of control over…

  9. Human adipose stem cell conditioned medium has a pro-fibrotic and EMT-stimulating effect on urethral fibroblasts in vitro

    European Journal of Cell Biology2026

    Fibrosis, characterized by excessive deposition of scar tissue, leads to the dysfunction of various organs. An urethral stricture, or pathological narrowing of the urethra, is an example of such scarring. The use of human adipose stem cell…

  10. Dynamic PEGDA-GelMA-HAMA microcarriers for efficient ex vivo expansion of human hematopoietic stem/progenitor cells

    Colloids and Surfaces B: Biointerfaces2026

    The clinical demand for hematopoietic stem cells (HSCs) far exceeds that of the available sources, driving the need for efficient ex vivo expansion technologies. A central challenge is the design of culture systems that promote HSCs…

Frequently asked

Which population does the evidence apply to?
Most studies investigated: animal.

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