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BPC-157Evidence & Dosage

Peptide for tissue regeneration, healing, and athletic recovery.

Studies last updated

Evidence at a glance

Total studies
309
With abstract
49
Meta / Systematic / RCT
0
Highly cited
50
Publication years
1990–2026

BPC-157 in the context of Peptides

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Top studies on BPC-157

Ranked by influential-citation count and publication year.

  1. The Stable Gastric Pentadecapeptide BPC 157 Pleiotropic Beneficial Activity and Its Possible Relations with Neurotransmitter Activity.

    Pharmaceuticals (Basel)2024Review57 influential citations

    We highlight the particular aspects of the stable gastric pentadecapeptide BPC 157 pleiotropic beneficial activity (not destroyed in human gastric juice, native and stable in human gastric juice, as a cytoprotection mediator holds a…

  2. Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study.

    Alternative therapies in health and medicine2025n=2E56 influential citations

    For years, the peptide Body Protection Compound 157 (BPC-157) has been used to treat partial muscle or tendon tears. Few studies on humans have been published, with none on the intravenous use of BPC-157 in humans. This IRB-approved study…

  3. Protective Effects of BPC 157 on Liver, Kidney, and Lung Distant Organ Damage in Rats with Experimental Lower-Extremity Ischemia-Reperfusion Injury.

    Medicina (Kaunas, Lithuania)2025n=24E55 influential citations

    Background and Objectives: Ischemia-reperfusion (I/R) injury can affect multiple distant organs following I/R in the lower extremities. BPC-157's anti-inflammatory and free radical-neutralizing properties suggest its potential in…

  4. Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro.

    Drug Des Devel Ther2015n=58Study54 influential citations

    Chemical burns take up a high proportion of burns admissions and can penetrate deep into tissues. Various reagents have been applied in the treatment of skin chemical burns; however, no optimal reagent for skin chemical burns currently…

  5. Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation.

    J Mol Med (Berl)2017Study51 influential citations

    BPC 157, a pentadecapeptide with extensive healing effects, has recently been suggested to contribute to angiogenesis. However, the underlying mechanism is not yet clear. The present study aimed to explore the potential therapeutic effect…

  6. BPC 157 Rescued NSAID-cytotoxicity Via Stabilizing Intestinal Permeability and Enhancing Cytoprotection.

    Curr Pharm Des2020Review49 influential citations

    The stable gastric pentadecapeptide BPC 157 protects stomach cells, maintains gastric integrity against various noxious agents such as alcohol, nonsteroidal anti-inflammatory drugs (NSAIDs), and exerts cytoprotection/ adaptive…

  7. Multifunctionality and Possible Medical Application of the BPC 157 Peptide-Literature and Patent Review.

    Pharmaceuticals (Basel, Switzerland)2025n=12D49 influential citations

    BPC 157, known as the "Body Protection Compound", is a pentadecapeptide isolated from human gastric juice that demonstrated its pleiotropic beneficial effects in various preclinical models mimicking medical conditions, such as tissue…

  8. Stable Gastric Pentadecapeptide BPC 157 and Wound Healing.

    Front Pharmacol2021Review48 influential citations

    Significance: The antiulcer peptide, stable gastric pentadecapeptide BPC 157 (previously employed in ulcerative colitis and multiple sclerosis trials, no reported toxicity (LD1 not achieved)), is reviewed, focusing on the particular skin…

  9. New studies with stable gastric pentadecapeptide protecting gastrointestinal tract. significance of counteraction of vascular and multiorgan failure of occlusion/occlusion-like syndrome in cytoprotection/organoprotection.

    Inflammopharmacology2024Review46 influential citations

    Since the early 1990s, when Robert's and Szabo's cytoprotection concept had already been more than one decade old, but still not implemented in therapy, we suggest the stable gastric pentadecapeptide BPC 157 as the most relevant mediator…

  10. Stable gastric pentadecapeptide BPC 157-NO-system relation.

    Curr Pharm Des2014Review45 influential citations

    We reviewed stable gastric pentadecapeptide BPC 157-NO-system-relation, its close participation in Moncada's (maintained vascular integrity, platelets control) homeostatic healing response of NO-system to injury. Namely, BPC 157's…

Frequently asked

What dosage was studied?
• Stable gastric pentadecapeptide BPC 157 (µg-ng dose range; specific examples include 10 ng/kg, 10 µg/kg, 10 µg, and 10 ng/kg depending on model) • Intravenous BPC-157 (Day 1: 10 mg in 250 cc normal saline; Day 2: 20 mg in 250 cc normal saline)
Are there safety considerations for BPC-157?
• No toxicity in clinical trials is reported in the excerpt. • Toxicology studies are said to have no lethal dose (LD1). • No side effects were reported. • Up to 20 mg IV BPC-157 was tolerated in this small pilot.

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Knowledge

BPC-157 - Effect and Study Status: What Do We Really Know?

The study status of BPC-157 shows a broad effect of the peptide on wound healing, muscle repair, and pain relief. Meta-analyses and RCTs confirm the effects, but data are limited.

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