KPVEvidence & Dosage

Top studies on KPV

Ranked by influential-citation count and publication year.

1. 01

   Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases.

   Endocrine reviews·200872 influential citations

   Alpha-MSH is a tridecapeptide derived from proopiomelanocortin. Many studies over the last few years have provided evidence that alpha-MSH has potent protective and antiinflammatory effects. These effects can be elicited via centrally…

2. 02

   Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis

   Molecular Therapy·201759 influential citations

   Overcoming adverse effects and selectively delivering drug to target cells are two major challenges in the treatment of ulcerative colitis (UC). Lysine-proline-valine (KPV), a naturally occurring tripeptide, has been shown to attenuate the…

3. 03

   <i>In situ</i>mucoadhesive hydrogel capturing tripeptide KPV: the anti-inflammatory, antibacterial and repairing effect on chemotherapy-induced oral mucositis

   Biomaterials Science·202227 influential citations

   In situ mucoadhesive hydrogels with inherent antibacterial activity were constructed from temperature-sensitive PPP as a matrix and EGCG as an adhesion enhancer. The hydrogel was designed for cancer patients with chemotherapy-induced oral…

4. 04

   PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation

   Gastroenterology·200826 influential citations

   <h4>Background & aims</h4>KPV is a tripeptide (Lys-Pro-Val), which possesses anti-inflammatory properties; however, its mechanisms of action still remain unknown. PepT1 is a di/tripeptide transporter normally expressed in the small…

5. 05

   A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon

   Acta Biomaterialia·202226 influential citations

   Ulcerative colitis (UC) usually occurs in the superficial mucosa of the colorectum. Here, a double-network hydrogel (PMSP) was constructed from maleimided γ-polyglutamic acid and thiolated γ-polyglutamic acid through crosslinking of…

6. 06

   Cell-penetrating peptides released from thermosensitive nanoparticles suppress pro-inflammatory cytokine response by specifically targeting inflamed cartilage explants.

   Nanomedicine : nanotechnology, biology, and medicine·201319 influential citations

   Cell-penetrating anti-inflammatory peptide KAFAKLAARLYRKALARQLGVAA (KAFAK) has the ability to suppress pro-inflammatory cytokines TNF-α and IL-6 when released from degradable and non-degradable poly(NIPAm-AMPS) nanoparticles. In vitro…

7. 07

   Self-Cross-Linked Hydrogel of Cysteamine-Grafted γ-Polyglutamic Acid Stabilized Tripeptide KPV for Alleviating TNBS-Induced Ulcerative Colitis in Rats

   ACS Biomaterials Science &amp; Engineering·202113 influential citations

   KPV (Lys-Pro-Val), which is a tripeptide derived from α-MSH (α-melanocyte-stimulating hormone), has an anti-inflammatory effect on colitis. However, KPV solution is very unstable when rectally administered, compromising its therapeutic…

8. 08

   Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease

   Inflammatory Bowel Diseases·200811 influential citations

   <h4>Background</h4>Despite some progress in recent years, the options for treating inflammatory bowel disease (IBD) are still dissatisfying, and surgery rates are still high. The anti-inflammatory effects of melanocortin peptides such as…

9. 09

   α-Melanocyte-Stimulating Hormone, MSH 11–13 KPV and Adrenocorticotropic Hormone Signalling in Human Keratinocyte Cells

   Journal of Investigative Dermatology·200411 influential citations

   alpha-MSH signals by binding to the melanocortin-1 receptor (MC-1R) and elevating cyclic AMP in several different cells. The anti-inflammatory properties of this peptide are also believed to be cyclic AMP dependent. The carboxyl terminal…

10. 10

    Critical Role of PepT1 in Promoting Colitis-Associated Cancer and Therapeutic Benefits of the Anti-inflammatory PepT1-Mediated Tripeptide KPV in a Murine Model

    Cellular and Molecular Gastroenterology and Hepatology·201610 influential citations

    <h4>Background and aims</h4>The human intestinal peptide transporter 1, hPepT1, is expressed in the small intestine at low levels in the healthy colon and upregulated during inflammatory bowel disease. hPepT1 plays a role in mouse colitis…