Sleep & ImmunityEvidence & Dosage
Cytokines, vaccine response, cold frequency under sleep deprivation.
Evidence at a glance
- Total studies
- 103
- With abstract
- 50
- Meta / Systematic / RCT
- 0
- Highly cited
- 39
- Publication years
- 1986–2026
Sleep & Immunity in the context of Sleep
This topic is part of our "Sleep" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to SleepTop studies on Sleep & Immunity
Ranked by influential-citation count and publication year.
The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms.
Journal of neuroinflammation2025200 influential citationsMajor depressive disorder is a prevalent mental disorder, yet its pathogenesis remains poorly understood. Accumulating evidence implicates dysregulated immune mechanisms as key contributors to depressive disorders. This review elucidates…
Neuroimmune interplay during type 2 inflammation: Symptoms, mechanisms, and therapeutic targets in atopic diseases.
The Journal of allergy and clinical immunology2024146 influential citationsType 2 inflammation is characterized by overexpression and heightened activity of type 2 cytokines, mediators, and cells that drive neuroimmune activation and sensitization to previously subthreshold stimuli. The consequences of altered…
The immunopathogenesis of narcolepsy type 1.
Nature reviews. Immunology2024119 influential citationsNarcolepsy type 1 (NT1) is a chronic sleep disorder resulting from the loss of a small population of hypothalamic neurons that produce wake-promoting hypocretin (HCRT; also known as orexin) peptides. An immune-mediated pathology for NT1…
Mind and skin: Exploring the links between inflammation, sleep disturbance and neurocognitive function in patients with atopic dermatitis.
Allergy2024118 influential citationsAtopic dermatitis (AD) is a chronic, pruritic and inflammatory, dry skin condition with many known comorbidities. These include airway disease, food allergies, atopic eye disease and autoimmune conditions. Furthermore, there is often…
The role of cytokines in physiological sleep regulation.
Annals of the New York Academy of Sciences200182 influential citationsSeveral growth factors (GFs) are implicated in sleep regulation. It is posited that these GFs are produced in response to neural activity and affect input-output relationships within the neural circuits where they are produced, thereby…
Stress-induced immune dysregulation: implications for wound healing, infectious disease and cancer.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology200681 influential citationsThe communication between the central nervous system and the immune system occurs via a complex network of bidirectional signals linking the nervous, endocrine and immune systems. The field of psychoneuroimmunology (PNI) has provided new…
Cytokines and sleep.
Sleep medicine reviews200578 influential citationsPersonal experience and empirical data indicate sleep is altered during sickness. Important signaling molecules of the peripheral immune system called cytokines orchestrate responses to infection. Through a variety of mechanisms, the brain…
Heat of the night: sleep disturbance activates inflammatory mechanisms and induces pain in rheumatoid arthritis.
Nature reviews. Rheumatology202374 influential citationsSleep has a homeostatic role in the regulation of the immune system and serves to constrain activation of inflammatory signalling and expression of cellular inflammation. In patients with rheumatoid arthritis (RA), a misaligned…
Effects of sleep and sleep loss on immunity and cytokines.
Brain, behavior, and immunity200265 influential citationsSleep is hypothesized to be a restorative process that is important for the proper functioning of the immune system. Severity of disordered sleep in depressed- and alcoholic subjects correlates with declines in natural- and cellular…
The inflammatory response system and the availability of plasma tryptophan in patients with primary sleep disorders and major depression.
Journal of affective disorders199859 influential citations<h4>Background</h4>It is now well established that major depression is accompanied by an immune-inflammatory system response and that indicators of the latter are inversely correlated with lower availability of plasma tryptophan in…
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