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Vitamins & Minerals

Ferritin & IronEvidence & Dosage

Ferritin, transferrin saturation, iron deficiency vs. iron overload.

Studies last updated

Evidence at a glance

Total studies
255
With abstract
41
Meta / Systematic / RCT
0
Highly cited
8
Publication years
1991–2026

Ferritin & Iron in the context of Vitamins & Minerals

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Top studies on Ferritin & Iron

Ranked by influential-citation count and publication year.

  1. Ferric carboxymaltose in patients with heart failure and iron deficiency.

    The New England journal of medicine2009n=459200 influential citations

    <h4>Background</h4>Iron deficiency may impair aerobic performance. This study aimed to determine whether treatment with intravenous iron (ferric carboxymaltose) would improve symptoms in patients who had heart failure, reduced left…

  2. Long-term serum ferritin dynamics in patients receiving antiviral treatment for hepatitis C virus infection

    Journal of the Formosan Medical Association2026n=1,53890 influential citations

    <h4>Background</h4>Limited data exists regarding the long-term serum ferritin dynamics following sustained virologic response (SVR<sub>12</sub>) and factors associated with trends in changes among patients undergoing treatment for…

  3. NCOA4-Mediated Ferritinophagy Induces Ferroptosis and Enriches Ferritin-Containing EVs via Ferritin Phase Separation to Promote Mechanical Ventilation-Induced Pulmonary Fibrosis

    Journal of Advanced Research202650 influential citations

    <h4>Introduction</h4>Mechanical ventilation (MV) is essential for treating respiratory failure but can paradoxically lead to pulmonary fibrosis. The mechanisms of MV-induced pulmonary fibrosis (MVPF) remain poorly understood.…

  4. Anemia and iron metabolism in COVID-19: a systematic review and meta-analysis

    European Journal of Epidemiology2020n=5720 influential citations

    Iron metabolism and anemia may play an important role in multiple organ dysfunction syndrome in Coronavirus disease 2019 (COVID-19). We conducted a systematic review and meta-analysis to evaluate biomarkers of anemia and iron metabolism…

  5. Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis

    Journal of clinical laboratory analysis (Print)2020n=1911 influential citations

    Objective The coronavirus disease 2019 (COVID‐19) has rapidly developed into a pandemic. Increased levels of ferritin due to cytokine storm and secondary hemophagocytic lymphohistiocytosis were found in severe COVID‐19 patients. Therefore,…

  6. Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron.

    Proceedings of the National Academy of Sciences of the United States of America199111 influential citations

    Synthesis of the iron-storage protein ferritin is thought to be regulated at the translational level by the cytosolic content of chelatable iron. This response to iron is regulated by the iron-modulated binding to ferritin mRNAs of a…

  7. Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis

    Redox Biology20206 influential citations

    Cellular iron, at the physiological level, is essential to maintain several metabolic pathways, while an excess of free iron may cause oxidative damage and/or provoke cell death. Consequently, iron homeostasis has to be tightly controlled.…

  8. NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and microferritinophagy

    Journal of Cell Biology20226 influential citations

    A ferritin particle consists of 24 ferritin proteins (FTH1 and FTL) and stores iron ions within it. During iron deficiency, ferritin particles are transported to lysosomes to release iron ions. Two transport pathways have been reported:…

  9. The Role of Ferritin in Health and Disease: Recent Advances and Understandings

    Metabolites20224 influential citations

    Systemic iron homeostasis needs to be tightly controlled, as both deficiency and excess iron cause major global health concerns, such as iron deficiency anemia, hemochromatosis, etc. In mammals, sufficient dietary acquisition is critical…

  10. Three Aromatic Residues are Required for Electron Transfer during Iron Mineralization in Bacterioferritin.

    Angewandte Chemie (Weinheim an der Bergstrasse, Germany)2015E3 influential citations

    Ferritins are iron storage proteins that overcome the problems of toxicity and poor bioavailability of iron by catalyzing iron oxidation and mineralization through the activity of a diiron ferroxidase site. Unlike in other ferritins, the…

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