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Vitamins & Minerals

Vitamin OptimizationEvidence & Dosage

Vitamin optimization strategies: needs assessment, bioavailability, synergies, and safety upper limits for the most relevant micronutrients.

Studies last updated

Evidence at a glance

Total studies
442
With abstract
20
Meta / Systematic / RCT
135
Highly cited
27
Publication years
1981–2026

Vitamin Optimization in the context of Vitamins & Minerals

This topic is part of our "Vitamins & Minerals" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Vitamin Optimization

Ranked by influential-citation count and publication year.

  1. Impact of nutrition on skin wound healing and aesthetic outcomes: A comprehensive narrative review.

    JPRAS Open2024Review196 influential citations

    While current wound treatment strategies often focus on antimicrobials and topical agents, the role of nutrition in wound healing and aesthetic outcomes is crucial but frequently overlooked. This review assesses the impact of specific…

  2. Bone Health Optimization (BHO) in Spine Surgery.

    Spine (Phila Pa 1976)2023review86 influential citations

    STUDY DESIGN: Literature review. OBJECTIVE: To educate spine surgeons on the importance of bone health optimization in surgical patients. SUMMARY OF BACKGROUND DATA: Osteoporosis is common and underdiagnosed in spine surgery patients. Poor…

  3. Exercise and nutrition strategies for sarcopenia in older adults: evidence from a network meta-analysis based on EWGSOP and AWGS criteria.

    Front Nutr2025n=2,331Systematic Review27 influential citations

    <h4>Objectives</h4>This network meta-analysis aimed to evaluate the comparative effectiveness of different exercise and nutritional interventions on muscle strength, skeletal muscle mass, and physical function in older adults with…

  4. Daily or intermittent vitamin D supplementation in patients with or at risk of osteoporosis: Position statement from the GRIO.

    Joint Bone Spine2025review26 influential citations

    Advantages and disadvantages of intermittent versus daily vitamin D supplementation especially in adults with or at risk of osteoporosis are discussed by the Osteoporosis Research and Information Group (GRIO). The analysis of the…

  5. Vitamin D deficiency in Hashimoto's thyroiditis: mechanisms, immune modulation, and therapeutic implications.

    Front Endocrinol (Lausanne)2025Review24 influential citations

    To evaluate vitamin D's role in thyroid autoimmunity modulation, establish evidence-based supplementation protocols, and address surgical implications in Hashimoto's thyroiditis (HT) care. Vitamin D deficiency is prevalent in HT patients…

  6. Vitamins formed by microorganisms in fermented foods: effects on human vitamin status-a systematic narrative review.

    Front Nutr2025n=18Systematic Review4 influential citations

    <h4>Introduction</h4>Vitamin deficiencies remain a global health issue, particularly among vulnerable populations. As microorganisms also produce vitamins, this has led to considering Fermented Foods (FF) as potential vehicles for…

  7. Effects of Randomized Multivitamin Supplementation on Carotenoids and α-Tocopherol in the COcoa Supplement and Multivitamin Outcomes Study.

    J Acad Nutr Diet2026n=399RCT2 influential citations

    <h4>Background</h4>Adequate intake of carotenoids and vitamin E supports healthy aging, yet evidence is limited on whether multivitamin-multimineral (MVM) supplementation changes serum concentrations over time.<h4>Objective</h4>The aim of…

  8. Is Vitamin D Fortification of Dairy Products Effective for Improving Vitamin D Status? A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

    Nutrients2025n=496Meta-Analysis2 influential citations

    <b>Background/objectives</b>: Given the suboptimal vitamin D intake and status among the United Kingdom population, the Scientific Advisory Committee on Nutrition is seeking suitable food vehicles for vitamin D fortification. Thus, this…

  9. The effectiveness and safety of the active form of folate on biochemical parameters in women of childbearing age: A systematic review and meta-analysis.

    Medicine (Baltimore)2025n=11Meta-Analysis2 influential citations

    <h4>Background</h4>Low folate levels in women of childbearing age can cause various health issues. Additionally, low perinatal folate concentrations are a significant cause of neural tube defects. Currently, folic acid supplements mainly…

  10. Assessment of the influence of vitamin D in patients with sepsis: a systematic review and meta-analysis.

    Front Nutr2025n=1,208Systematic Review2 influential citations

    <h4>Background</h4>This systematic review and meta-analysis seeks to extensively estimate the interrelation between vitamin D (VD) and clinical results among both pediatric and adult sepsis patients.<h4>Methods</h4>A search was implemented…

Frequently asked

What dosage was studied?
• Nutritional status optimization; specific nutrients/supplements (omega-3 fatty acids, amino acids, vitamins A/B/C/D/E, zinc, copper, magnesium, iron, polyphenols) (Varied by nutrient/study; review notes 30–35 kcal/kg, up to 40 kcal/kg underweight; fluid intake ~1 ml/kcal/day; preop nutrition 7–10 days) • Bone health optimization (screening, osteoporosis treatment, vitamin D/nutritional optimization, bone health assessment programs) (Not reported)
Which population does the evidence apply to?
Most studies investigated: unknown.
Are there safety considerations for Vitamin Optimization?
• Vitamin E may worsen scar cosmetic appearance. • Omega-3-enriched animal diets produced less robust wounds at 30 days. • TPN requires monitoring for refeeding syndrome and line complications. • Enteral/parenteral nutrition should be tailored to metabolic needs.

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Vitamin Optimization: What the Evidence Actually Shows

What actually helps with vitamin optimization? An evidence-based overview of effects, dose, safety, and the limits of the literature — clear, sober, and backed by studies.

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