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Coenzyme Q10 (CoQ10 / Ubiquinol)Evidence & Dosage

Mitochondria, statins, energy, and cardiovascular outcomes.

Studies last updated

Evidence at a glance

Total studies
1,000
With abstract
50
Meta / Systematic / RCT
93
Highly cited
50
Publication years
1975–2026

Coenzyme Q10 (CoQ10 / Ubiquinol) in the context of Vitamins & Minerals

This topic is part of our "Vitamins & Minerals" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Coenzyme Q10 (CoQ10 / Ubiquinol)

Ranked by influential-citation count and publication year.

  1. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials.

    J Affect Disord2023n=52Meta-Analysis99 influential citations

    <h4>Background</h4>New research supports an integrated approach to treating depression, and lifestyle modifications should be a regular component of both preventative and treatment programs. Therefore, in order to investigate the…

    Finding: The subgroup analyses by scale type and country remained significant for the positive effects on depressive and anxiety states.

  2. The Effect of Nutrients and Dietary Supplements on Sperm Quality Parameters: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

    Adv Nutr2018n=28meta71 influential citations

    Infertility, which affects ∼15% of the world's population, is a global public health issue recognized by the WHO. Therefore, it is of major clinical and public health importance to investigate whether modifiable lifestyle factors-such as…

  3. Antioxidants and Fertility in Women with Ovarian Aging: A Systematic Review and Meta-Analysis.

    Adv Nutr2024n=20Meta-Analysis68 influential citations

    Ovarian aging is a major factor for female subfertility. Multiple antioxidants have been applied in different clinical scenarios, but their effects on fertility in women with ovarian aging are still unclear. To address this, a…

  4. The Effect of Antioxidants on Sperm Quality Parameters and Pregnancy Rates for Idiopathic Male Infertility: A Network Meta-Analysis of Randomized Controlled Trials.

    Front Endocrinol (Lausanne)2022n=1,917Meta-Analysis66 influential citations

    Purpose Male infertility is a global public health issue recognized by the WHO. Recently, antioxidants are increasingly used to treat idiopathic male infertility. However, the lack of available evidence has led to the inability to rank the…

    Finding: In this network meta-analysis of men with idiopathic male infertility, l-carnitine was ranked first for sperm motility and sperm morphology.

  5. Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials.

    J Am Heart Assoc2018n=575Meta-Analysis56 influential citations

    Background Previous studies have demonstrated a possible association between the induction of coenzyme Q10 (CoQ10) after statin treatment and statin‐induced myopathy. However, whether CoQ10 supplementation ameliorates statin‐induced…

    Finding: Coenzyme Q10 supplementation ameliorated statin-associated muscle symptoms compared with placebo in this meta-analysis.

  6. Alleviating effects of coenzyme Q10 supplements on biomarkers of inflammation and oxidative stress: results from an umbrella meta-analysis.

    Front Pharmacol2023n=13Systematic Review53 influential citations

    Introduction: Although several meta-analyses support the positive effect of coenzyme Q10 (CoQ10) on biomarkers of oxidative stress and inflammation, the results of some other studies reject such effects. Methods: Therefore, in this…

  7. The effects of coenzyme Q10 supplementation on biomarkers of exercise-induced muscle damage, physical performance, and oxidative stress: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.

    Clin Nutr ESPEN2024n=28Meta-Analysis52 influential citations

    <h4>Purpose</h4>This study aims to elucidate the dose-dependent effect of coenzyme Q10 supplementation (CoQ10) on exercise-induced muscle damage (EIMD), physical performance, and oxidative stress in adults.<h4>Methods</h4>A systematic…

  8. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials.

    J Hum Hypertens2007n=362Meta-Analysis42 influential citations

    Our objective was to review all published trials of coenzyme Q10 for hypertension, assess overall efficacy and consistency of therapeutic action and side effect incidence. Meta-analysis was performed in 12 clinical trials (362 patients)…

    Finding: The authors concluded that coenzyme Q10 may lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm Hg without significant side effects.

  9. Oral antioxidant therapy for prevention and treatment of preeclampsia: Meta-analysis of randomized controlled trials.

    Nutr Metab Cardiovasc Dis2018n=29Meta-Analysis41 influential citations

    <h4>Aims</h4>To determine whether oral antioxidant therapies, of various types and doses, are able to prevent or treat women with preeclampsia.<h4>Data synthesis</h4>The following databases were searched: MEDLINE, CENTRAL, LILACS, and Web…

    Finding: A beneficial effect of antioxidant therapy was found for intrauterine growth restriction in the treatment studies.

  10. Coenzyme Q10 supplementation and oxidative stress parameters: a systematic review and meta-analysis of clinical trials.

    Eur J Clin Pharmacol2020n=17Meta-Analysis40 influential citations

    <h4>Purpose</h4>Oxidative stress (OS) is associated with several chronic complications and diseases. The use of coenzyme Q10 (CoQ10) as an adjuvant treatment with routine clinical therapy against metabolic diseases has shown to be…

    Finding: In this meta-analysis of 17 randomized clinical trials, coenzyme Q10 supplementation significantly decreased malondialdehyde (MDA).

Frequently asked

What does the evidence say about Coenzyme Q10 (CoQ10 / Ubiquinol)?
The subgroup analyses by scale type and country remained significant for the positive effects on depressive and anxiety states.
What dosage was studied?
• Antioxidant supplementation (including magnesium, zinc, selenium, CoQ10, tea and coffee, and crocin) (Not reported) • Nutrients, dietary supplements, or food: selenium, zinc, omega-3 fatty acids, coenzyme Q10, carnitines (Not reported in excerpt) • Antioxidants, including coenzyme Q10, melatonin, myo-inositol, vitamins, resveratrol, and acetyl-L-carnitine/N-acetyl-L-cysteine/α-lipoic acid (Varied by antioxidant: CoQ10 30-1200 mg/d; melatonin 2-16 mg/d; myo-inositol 4 g/d; vitamins varied; resveratrol 150 mg/d; combination regimen unspecified)
Are there safety considerations for Coenzyme Q10 (CoQ10 / Ubiquinol)?
• Not reported • Not reported in excerpt • Adverse events included congenital missing kidney, low birth weight, and preterm birth. • Minor side effects reported were headache, dizziness, nausea, and vomiting.

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