Back to Diagnostics & Biomarkers
Diagnostics & Biomarkers

HbA1cEvidence & Dosage

3-Monats-Mittel des Blutzuckers, diabetisches Risiko, Longevity-Marker.

Studies last updated

Evidence at a glance

Total studies
1,000
With abstract
47
Meta / Systematic / RCT
152
Highly cited
6
Publication years
1990–2027

HbA1c in the context of Diagnostics & Biomarkers

This topic is part of our "Diagnostics & Biomarkers" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

Go to Diagnostics & Biomarkers

Top studies on HbA1c

Ranked by influential-citation count (Semantic Scholar) and publication year.

  1. Pre-diabetes and the risk for cardiovascular disease: a systematic review of the evidence.

    Journal of the American College of Cardiology2010111 influential citations

    <h4>Objectives</h4>Our objective was to estimate the magnitude of the relative risk (RR) for cardiovascular disease associated with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) from published prospective…

  2. Alpha-glucosidase inhibitors for type 2 diabetes mellitus.

    Cochrane Database Syst Rev2005n=813Meta-Analysis59 influential citations

    <h4>Background</h4>Alpha-glucosidase inhibitors such as acarbose or miglitol, have the potential to improve glycemic control in type 2 diabetes mellitus. The true value of these agents, especially in relation to diabetes related mortality…

  3. Glycemic variability correlates strongly with postprandial beta-cell dysfunction in a segment of type 2 diabetic patients using oral hypoglycemic agents.

    Diabetes care2009n=59E27 influential citations

    Glucose fluctuations trigger activation of oxidative stress, a main mechanism leading to secondary diabetes complications. We evaluated the relationship between glycemic variability and beta-cell dysfunction. We conducted a cross-sectional…

  4. Association between the Vicious Cycle of Diabetes-Associated Complications and Glycemic Control among the Elderly: A Systematic Review.

    Medicina (Kaunas)2018n=38Systematic Review12 influential citations

    Background and objectives: Improved quality of life (QoL) and life expectancy of elderly diabetic patients revolves around optimal glycemic control. Inadequate glycemic control may lead to the development of diabetes-associated…

  5. Tele-Cognitive Behavioral Therapy for the Treatment of Diabetes-Related Distress in Individuals With Diabetes Mellitus: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    J Med Internet Res2025n=2,467Meta-Analysis3 influential citations

    <h4>Background</h4>Diabetes-related distress (DD) is highly prevalent in individuals with diabetes mellitus (DM) and impairs quality of life. Tele-cognitive behavioral therapy (Tele-CBT) shows potential for reducing DM-related…

  6. Impact of stepwise diabetes technology advances in older adults with type 1 diabetes: A systematic review and meta-analysis of randomised trials.

    Diabetes Obes Metab2026n=482Meta-Analysis2 influential citations

    <h4>Objectives</h4>To evaluate the efficacy and safety of advancing to higher levels of diabetes technology in older adults with type 1 diabetes (T1D).<h4>Methods</h4>Web of Science, PubMed, Cochrane Library, and SCOPUS were searched.…

  7. Effects of probiotic supplementation on intestinal microbiota in patients with diabetes/prediabetes: a systematic review and meta-analysis of randomized controlled trials.

    Br J Nutr2026n=1,113Meta-Analysis2 influential citations

    This study systematically evaluates the effects of probiotic interventions on gut microbiota and clinical outcomes in diabetic patients to determine the optimal target population and conditions for effective use, with an emphasis on…

  8. Mediterranean diet for the management of pre-existing metabolic diseases: Evidence from a systematic review and meta-analysis featured in the Italian national guidelines "La Dieta Mediterranea".

    Nutrition2026n=69Meta-Analysis2 influential citations

    <h4>Background</h4>Metabolic diseases such as obesity, type 2 diabetes mellitus, metabolic syndrome, dyslipidemia, and non-alcoholic fatty liver disease are major contributors to cardiometabolic risk. While the Mediterranean diet (MD) is…

  9. Impact of the Mediterranean Diet on Glycemic Control, Body Mass Index, Lipid Profile, and Blood Pressure in Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials.

    Nutrients2025n=11Meta-Analysis2 influential citations

    <b>Background:</b> Type 2 diabetes mellitus (T2DM) is a growing global health challenge requiring effective dietary management strategies. While the Mediterranean diet shows promise for cardiovascular and metabolic health, the last…

  10. Evaluating the endothelial and metabolic effects of CPAP therapy in obstructive sleep apnea patients: Insights from a comprehensive meta-analysis.

    Sleep Med Rev2025Meta-Analysis2 influential citations

    Across a growing body of research, continuous positive airway pressure (CPAP) therapy has been consistently explored as a treatment for obstructive sleep apnea (OSA) due to its potential to mitigate vascular and metabolic risk factors.…

Frequently asked

What dosage was studied?
• Alpha-glucosidase inhibitors (acarbose, miglitol, voglibose) as monotherapy (Acarbose dosages higher than 50 mg TID; other doses not specified)
Which population does the evidence apply to?
Most studies investigated: unknown.
Are there safety considerations for HbA1c?
• Adverse effects were mostly gastrointestinal. • Adverse effects were dose dependent. • Acarbose caused more adverse effects than sulphonylurea. • Acarbose doses higher than 50 mg TID added adverse effects without extra HbA1c benefit.

Related articles

More topics in Diagnostics & Biomarkers

Blood Glucose

Nüchtern, postprandial, Glukoseschwankungen — Grundlage für metabolische Gesundheit.

Blood Pressure Tracking

Häusliche Messung, 24h-Messung, Weißkittelhypertonie.

Body Temperature Tracking

Basaltemperatur, Zyklus, Krankheit, Schlafphasen via Wearable.

Complete Blood Count

Kleines/großes Blutbild, Erythrozyten, Leukozyten, Thrombozyten — Standardpanel.

Continuous Glucose Monitor

Echtzeit-Blutzucker via Sensor — Lernkurve und Limitationen.

Cycle Tracking

Menstruationszyklus, Symptome, Fertilität — Apps und Wearables.

Fasting Insulin & HOMA-IR

Insulinresistenz früh erkennen — wichtiger als HbA1c bei Risiko-Patienten.

Geroscience Biomarkers

Automatisch via Trend Scout entdeckt. Aging biomarkers and biological clocks are central to longevity interventions and geroscience research.. PubMed: 479 Ergebnisse.

Homocysteine

Methylierungs-Marker, kardiovaskuläres und neurologisches Risiko.

HRV Tracking

Herzratenvariabilität als Resilienz- und Erholungs-Indikator.

Inflammation Markers

hs-CRP, IL-6, Fibrinogen — chronische niedriggradige Entzündung als Risikofaktor.

Kidney Values

Kreatinin, Harnstoff, eGFR, Cystatin C — Nierenfunktion bewerten.

Lipid Profile

LDL-C, HDL, Triglyceride, ApoB — moderne kardiovaskuläre Risiko-Bewertung.

Liver Values

ALT, AST, GGT, Bilirubin — was hohe Werte bedeuten und wann sie ein Problem sind.

Mood Tracking

Daily Mood Logging, Korrelationen mit Schlaf/Bewegung/Ernährung.

Nutrition Tracking

Cronometer, MyFitnessPal, Makros & Mikros, Limitationen.

Resting Heart Rate

Trend-Marker für kardiovaskuläre Fitness und Übertraining.

Thyroid Panel

TSH, fT3, fT4, ggf. reverse T3 und Antikörper — vollständiges Schilddrüsen-Panel.

VO2max

Maximale Sauerstoffaufnahme — stärkster Longevity-Prädiktor.

Wearables

Übersicht: Oura, Whoop, Apple Watch, Garmin, Fitbit — Vor- und Nachteile.

Related topics from other worlds