HbA1cEvidence & Dosage
A 3-month average of blood sugar, diabetes risk, a longevity marker.
Evidence at a glance
- Total studies
- 1,000
- With abstract
- 47
- Meta / Systematic / RCT
- 152
- Highly cited
- 6
- Publication years
- 1990–2027
HbA1c in the context of Diagnostics & Biomarkers
This topic is part of our "Diagnostics & Biomarkers" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to Diagnostics & BiomarkersTop studies on HbA1c
Ranked by influential-citation count and publication year.
Pre-diabetes and the risk for cardiovascular disease: a systematic review of the evidence.
Journal of the American College of Cardiology2010111 influential citations<h4>Objectives</h4>Our objective was to estimate the magnitude of the relative risk (RR) for cardiovascular disease associated with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) from published prospective…
Alpha-glucosidase inhibitors for type 2 diabetes mellitus.
Cochrane Database Syst Rev2005n=813Meta-Analysis59 influential citations<h4>Background</h4>Alpha-glucosidase inhibitors such as acarbose or miglitol, have the potential to improve glycemic control in type 2 diabetes mellitus. The true value of these agents, especially in relation to diabetes related mortality…
Glycemic variability correlates strongly with postprandial beta-cell dysfunction in a segment of type 2 diabetic patients using oral hypoglycemic agents.
Diabetes care2009n=59E27 influential citationsGlucose fluctuations trigger activation of oxidative stress, a main mechanism leading to secondary diabetes complications. We evaluated the relationship between glycemic variability and beta-cell dysfunction. We conducted a cross-sectional…
Association between the Vicious Cycle of Diabetes-Associated Complications and Glycemic Control among the Elderly: A Systematic Review.
Medicina (Kaunas)2018n=38Systematic Review12 influential citationsBackground and objectives: Improved quality of life (QoL) and life expectancy of elderly diabetic patients revolves around optimal glycemic control. Inadequate glycemic control may lead to the development of diabetes-associated…
Tele-Cognitive Behavioral Therapy for the Treatment of Diabetes-Related Distress in Individuals With Diabetes Mellitus: Systematic Review and Meta-Analysis of Randomized Controlled Trials.
J Med Internet Res2025n=2,467Meta-Analysis3 influential citations<h4>Background</h4>Diabetes-related distress (DD) is highly prevalent in individuals with diabetes mellitus (DM) and impairs quality of life. Tele-cognitive behavioral therapy (Tele-CBT) shows potential for reducing DM-related…
Impact of stepwise diabetes technology advances in older adults with type 1 diabetes: A systematic review and meta-analysis of randomised trials.
Diabetes Obes Metab2026n=482Meta-Analysis2 influential citations<h4>Objectives</h4>To evaluate the efficacy and safety of advancing to higher levels of diabetes technology in older adults with type 1 diabetes (T1D).<h4>Methods</h4>Web of Science, PubMed, Cochrane Library, and SCOPUS were searched.…
Effects of probiotic supplementation on intestinal microbiota in patients with diabetes/prediabetes: a systematic review and meta-analysis of randomized controlled trials.
Br J Nutr2026n=1,113Meta-Analysis2 influential citationsThis study systematically evaluates the effects of probiotic interventions on gut microbiota and clinical outcomes in diabetic patients to determine the optimal target population and conditions for effective use, with an emphasis on…
Mediterranean diet for the management of pre-existing metabolic diseases: Evidence from a systematic review and meta-analysis featured in the Italian national guidelines "La Dieta Mediterranea".
Nutrition2026n=69Meta-Analysis2 influential citations<h4>Background</h4>Metabolic diseases such as obesity, type 2 diabetes mellitus, metabolic syndrome, dyslipidemia, and non-alcoholic fatty liver disease are major contributors to cardiometabolic risk. While the Mediterranean diet (MD) is…
Impact of the Mediterranean Diet on Glycemic Control, Body Mass Index, Lipid Profile, and Blood Pressure in Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials.
Nutrients2025n=11Meta-Analysis2 influential citations<b>Background:</b> Type 2 diabetes mellitus (T2DM) is a growing global health challenge requiring effective dietary management strategies. While the Mediterranean diet shows promise for cardiovascular and metabolic health, the last…
Evaluating the endothelial and metabolic effects of CPAP therapy in obstructive sleep apnea patients: Insights from a comprehensive meta-analysis.
Sleep Med Rev2025Meta-Analysis2 influential citationsAcross a growing body of research, continuous positive airway pressure (CPAP) therapy has been consistently explored as a treatment for obstructive sleep apnea (OSA) due to its potential to mitigate vascular and metabolic risk factors.…
Frequently asked
What dosage was studied?
Which population does the evidence apply to?
Are there safety considerations for HbA1c?
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HbA1c: Effects & Evidence — what is actually supported?
Evidence-based overview of HbA1c: what the value really indicates, how strong the data are, and where the limits are. Evidence check included.
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Berberine for Blood Sugar and Insulin Resistance: What the Studies Really Show
Berberine lowers blood sugar and HbA1c moderately in studies, but the evidence is heterogeneous. Here: evidence base, dosage, risks, and comparison with metformin.
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