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Diagnostics & Biomarkers

Geroscience BiomarkersEvidence & Dosage

Automatisch via Trend Scout entdeckt. Aging biomarkers and biological clocks are central to longevity interventions and geroscience research.. PubMed: 479 Ergebnisse.

Studies last updated

Evidence at a glance

Total studies
316
With abstract
49
Meta / Systematic / RCT
7
Highly cited
21
Publication years
2009–2026

Geroscience Biomarkers in the context of Diagnostics & Biomarkers

This topic is part of our "Diagnostics & Biomarkers" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Geroscience Biomarkers

Ranked by influential-citation count (Semantic Scholar) and publication year.

  1. A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer's disease.

    EBioMedicine2025n=12Study168 influential citations

    <h4>Background</h4>This single-arm study evaluates the feasibility, safety, and preliminary effects of two senolytic agents, Dasatinib and Quercetin (DQ), in older adults at risk of Alzheimer's disease.<h4>Methods</h4>Participants took 100…

  2. A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup.

    Geroscience2018Review98 influential citations

    Recent advances indicate that biological aging is a potentially modifiable driver of late-life function and chronic disease and have led to the development of geroscience-guided therapeutic trials such as TAME (Targeting Aging with…

  3. Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases.

    Trends Biochem Sci2020Review68 influential citations

    Aging is a major risk factor for numerous human pathologies, including cardiovascular, metabolic, musculoskeletal, and neurodegenerative conditions and various malignancies. While our understanding of aging is far from complete, recent…

  4. Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis.

    J Gerontol A Biol Sci Med Sci2017n=220RCT58 influential citations

    Biological aging measures have been proposed as proxies for extension of healthy life span in trials of geroprotective therapies that aim to slow aging. Several methods to measure biological aging show promise but it is not known if these…

  5. The emerging role of miRNAs in biological aging and age-related diseases.

    Noncoding RNA Res2025Review55 influential citations

    Ageing is a complex biological process characterised by the accumulation of molecular and cellular damage leading to functional decline and an increased risk of chronic disease and geriatric syndromes. Despite data showing that lifestyle…

  6. The Business of Anti-Aging Science.

    Trends Biotechnol2017Review35 influential citations

    Age-related conditions are the leading causes of death and health-care costs. Reducing the rate of aging would have enormous medical and financial benefits. Myriad genes and pathways are known to regulate aging in model organisms,…

  7. Drugs Targeting Mechanisms of Aging to Delay Age-Related Disease and Promote Healthspan: Proceedings of a National Institute on Aging Workshop.

    J Gerontol A Biol Sci Med Sci2023Study32 influential citations

    The geroscience hypothesis posits that by targeting key hallmarks of aging we may simultaneously prevent or delay several age-related diseases and thereby increase healthspan, or life span spent free of significant disease and disability.…

  8. Endpoints for geroscience clinical trials: health outcomes, biomarkers, and biologic age.

    Geroscience2022Study27 influential citations

    Treatments that target fundamental processes of aging are expected to delay several aging-related conditions simultaneously. Testing the efficacy of these treatments for potential anti-aging benefits will require clinical trials with…

  9. Sex differences in epigenetic ageing for older people living with HIV.

    EBioMedicine2025Study23 influential citations

    <h4>Background</h4>HIV-1 infection impacts biological ageing, and epigenetic clocks highlight epigenetic age acceleration in people with HIV. Despite evidence indicating sex differences in clinical, immunological, and virological measures,…

  10. The epitranscriptome in ageing and stress resistance: A systematic review.

    Ageing Res Rev2022Systematic Review17 influential citations

    Modifications of RNA, collectively called the "epitranscriptome", might provide novel biomarkers and innovative targets for interventions in geroscience but are just beginning to be studied in the context of ageing and stress resistance.…

Frequently asked

What dosage was studied?
• Dasatinib and Quercetin (senolytics) (100 mg Dasatinib and 1250 mg Quercetin)
Are there safety considerations for Geroscience Biomarkers?
• No serious adverse events were related to the intervention. • Not reported in the abstract. • Not reported; review article with no intervention safety data. • No adverse events reported; conceptual article only.

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