HomocysteineEvidence & Dosage
Methylation marker, cardiovascular and neurological risk.
Evidence at a glance
- Total studies
- 1,000
- With abstract
- 48
- Meta / Systematic / RCT
- 2
- Highly cited
- 2
- Publication years
- 1985–2026
Homocysteine in the context of Diagnostics & Biomarkers
This topic is part of our "Diagnostics & Biomarkers" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to Diagnostics & BiomarkersTop studies on Homocysteine
Ranked by influential-citation count and publication year.
Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker.
Clinica chimica acta; international journal of clinical chemistry200240 influential citationsPlasma homocysteine (Hcy), a well-known independent risk factor for coronary heart disease, is also a risk factor for cancer. Results from our studies indicate that Hcy could be used as a tumor marker. We found elevated circulating total…
The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease.
Neurobiology of aging2002n=2734 influential citationsThere is evidence that increased blood concentrations of homocysteine may be a risk factor for Alzheimer's disease. (E)-4-hydroxy-2-nonenal (HNE) is a neurotoxic product of lipid peroxidation that is increased in the ventricular fluid and…
The association of homocysteine and coronary artery disease.
Clinical cardiology2003D4 influential citationsHyperhomocysteinemia has been associated with increased risk of atherosclerosis and myocardial infarction by a number of prospective case-control studies. A variety of genetic mutations, nutritional deficiencies, disease states, and drugs…
Homocysteine and diabetic retinopathy
Experimental Eye Research20262 influential citationsDiabetic retinopathy (DR), a leading cause of blindness in working-age adults, is a complex neurovascular complication of diabetes mellitus. Beyond chronic hyperglycemia, hyperhomocysteinemia (HHcy) has emerged as a significant modulator…
Elevated Homocysteine is Associated With Liver Fibrosis in Metabolic Dysfunction–Associated Steatotic Liver Disease in a Sex- and Menopause-Specific Manner
Gastro Hep Advances2026n=8,2532 influential citations<h4>Background and aims</h4>Elevated hepatic homocysteine (Hcy) contributes to hepatic inflammation and fibrogenesis in metabolic dysfunction-associated steatotic liver disease (MASLD). We aimed to evaluate the association between serum…
Synbiotic combination of Bifidobacterium longum BB536 and lactulose improves the presenteeism of healthy adults associated with aromatic lactic acids - A single-arm, open-label study.
Gut microbes reports20252 influential citationsGut microbiota and their metabolites are crucial for metabolic regulation, immunomodulation, and brain and mental functions via the brain-gut axis. Synbiotics offer an effective strategy for improving gut health by modulating gut…
Disparities in Plasma Homocysteine Levels Between Early-Onset and Late-Onset Depression.
Depress Anxiety2024n=202Study2 influential citationsBackground: Elevated homocysteine levels and late-life depression are risk factors for cognitive decline: a comparative study highlighted the association of late-onset depression (LOD) with more significant cognitive deficits and brain…
Research Progress on the Effect of Exercise on Homocysteine
Current Medicinal Chemistry20261 influential citationsThe effect of exercise on homocysteine (Hcy) levels is multifaceted and varies significantly across different populations. This review investigates how various exercise modalities-moderate to vigorous physical activity, acute intense…
The study on serum oxidized low-density lipoprotein and homocysteine as cardiovascular risk markers in subclinical hypothyroidism patients
Frontiers in Endocrinology2026n=6761 influential citationsPurpose Hypothyroidism, the most prevalent endocrine disorder globally, is associated with increased cardiovascular risk. This study aims to evaluate cardiovascular risk factors—including serum oxidized low-density lipoprotein (ox-LDL),…
Association of serum and vitreous homocysteine and uric acid concentrations with post-vitrectomy prognosis in patients with proliferative diabetic retinopathy
World Journal of Diabetes2026n=441 influential citationsBACKGROUND Proliferative diabetic retinopathy (PDR) is a major cause of vision loss, often requiring pars plana vitrectomy (PPV). Systemic and intraocular metabolic alterations, including dysregulation of homocysteine (Hcy) and uric acid…
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