TRTEvidence & Dosage
Testosterone replacement as a medical topic — indications, risks.
Evidence at a glance
- Total studies
- 141
- With abstract
- 48
- Meta / Systematic / RCT
- 6
- Highly cited
- 17
- Publication years
- 1999–2026
TRT in the context of Hormones
This topic is part of our "Hormones" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to HormonesTop studies on TRT
Ranked by influential-citation count and publication year.
Adjuvant or early salvage radiotherapy for the treatment of localised and locally advanced prostate cancer: a prospectively planned systematic review and meta-analysis of aggregate data.
Lancet (London, England)2020n=2,153156 influential citations<h4>Background</h4>It is unclear whether adjuvant or early salvage radiotherapy following radical prostatectomy is more appropriate for men who present with localised or locally advanced prostate cancer. We aimed to prospectively plan a…
Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials.
The journals of gerontology. Series A, Biological sciences and medical sciences2005n=651152 influential citations<h4>Background</h4>We performed a meta-analysis of randomized clinical trials to determine the risks of adverse events associated with testosterone replacement in older men.<h4>Methods</h4>The MEDLINE database was searched from 1966 to…
Testosterone supplementation and bone parameters: a systematic review and meta-analysis study.
J Endocrinol Invest2022n=310Meta-Analysis60 influential citations<h4>Background</h4>The role of testosterone (T) replacement therapy (TRT) in subjects with late onset hypogonadism is still the object of an intense debate.<h4>Methods</h4>All observational studies and placebo-controlled or -uncontrolled…
Finding: Testosterone replacement therapy was associated with a significant reduction of bone resorption markers in observational studies but not in controlled studies.
A Systematic Review and Meta-analysis of the Effectiveness and Toxicities of Lutetium-177-labeled Prostate-specific Membrane Antigen-targeted Radioligand Therapy in Metastatic Castration-Resistant Prostate Cancer.
European urology2021n=1,19254 influential citations<h4>Context</h4>Castration-resistant prostate cancer (CRPC) treatment is an evolving challenge. Prostate-specific membrane antigen (PSMA)-targeted endoradiotherapy/radioligand therapy (PRLT) with small-molecule, urea-based agents labeled…
Association between testosterone replacement therapy and cardiovascular outcomes: A meta-analysis of 30 randomized controlled trials.
Prog Cardiovasc Dis2024n=11,502Meta-Analysis42 influential citations<h4>Background</h4>The Cardiovascular safety of testosterone replacement therapy (TRT) among men with hypogonadism is not well established to date. Hence, we sought to evaluate the cardiovascular disease (CVD) outcomes among patients…
Cardiovascular safety of testosterone replacement therapy in men: an updated systematic review and meta-analysis.
Expert Opin Drug Saf2024n=15,436Meta-Analysis40 influential citations<h4>Introduction</h4>The cardiovascular (CV) safety of testosterone (T) replacement therapy (TRT) is still conflicting. Recent data suggested a TRT-related increased risk of atrial fibrillation (AF). The aim of this study was to systematic…
An updated systematic review and meta-analysis of the effects of testosterone replacement therapy on erectile function and prostate.
Front Endocrinol (Lausanne)2024n=28Meta-Analysis39 influential citations<h4>Introduction</h4>Testosterone replacement therapy (TRT) is a generally accepted method treating for aging-related late-onset hypogonadism (LOH). However, the efficacy and safety of TRT remain controversial. An updated systematic review…
Testosterone replacement therapy and vascular thromboembolic events: a systematic review and meta-analysis.
Asian journal of andrology202433 influential citationsTo evaluate the relationship between testosterone replacement therapy (TRT) and arterial and/or venous thrombosis in patients with pre-treatment total testosterone (TT) <12 nmol l -1 , we performed a meta-analysis following the Population…
Cardiovascular Outcomes of Hypogonadal Men Receiving Testosterone Replacement Therapy: A Meta-analysis of Randomized Controlled Trials.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists2024n=94129 influential citations<h4>Objective</h4>To investigate the impact of testosterone replacement therapy (TRT) on cardiovascular outcomes in hypogonadal men.<h4>Methods</h4>A meta-analysis of 26 randomized controlled trials involving 10 941 participants was…
Effects of Exercise During Radiation Therapy on Physical Function and Treatment-Related Side Effects in Men With Prostate Cancer: A Systematic Review and Meta-Analysis.
International journal of radiation oncology, biology, physics202123 influential citations<h4>Purpose</h4>Radiation therapy is a commonly used treatment for prostate cancer; however, the side effects may negatively affect quality of life and cause patients to be less physically active. Although exercise has been shown to…
Frequently asked
What dosage was studied?
Are there safety considerations for TRT?
More topics in Hormones
Adrenal Fatigue
A contested concept — what the evidence shows vs. how it's marketed.
Adrenal Glands
Cortisol, DHEA, adrenaline — the stress response and daily rhythm.
Adrenaline & Noradrenaline
Acute stress response, sympathetic nervous system, attention and reaction.
Chronic Stress
Allostatic load, immune and metabolic consequences, interventions.
Cortisol Daily Profile
The diurnal rhythm, CAR (cortisol awakening response), saliva measurement.
Cortisol Management
HPA axis, stress curve, adaptogens, and a healthy daily rhythm.
Cravings
Causes: blood-sugar swings, sleep deprivation, emotional eating.
Cycle Phases
Follicular phase, ovulation, luteal phase — adapting training and nutrition.
DHEA
DHEA as a precursor hormone for hormonal balance and vitality.
DHT
The most potent androgen metabolite — hair loss, prostate, libido.
Endometriosis
A chronic inflammatory disease — diagnosis, options, lifestyle factors.
Estrogen Balance
Women's optimization, aromatase, phytoestrogens, and menopause.
Free Testosterone
Bioavailable testosterone, SHBG's influence, clinical relevance.
fT3 & fT4
Free thyroid hormones — peripheral conversion and activity.
Ghrelin
Hunger hormone, sleep's influence, intermittent-fasting adaptation.
GLP-1
Glucagon-like peptide 1 — incretin, satiety, blood sugar, semaglutide's mechanism.
Growth Hormone (GH/IGF-1)
Sleep secretion, secretagogues and IGF-1 as biomarker
Hashimoto Thyroiditis
Autoimmune thyroid disease — TPO/TG antibodies, selenium, iodine caution.
Hormonal Contraception
The pill, IUD, risk profiles, side effects, alternatives.
Hormonal System
Endocrine glands, hormone axes, feedback loops — how hormones steer behavior and metabolism.
Related topics from other worlds
Speed-Strength
Power, plyometrics, Olympic lifts — training principles.
Warm-up
The RAMP protocol, dynamic stretching, neural activation.
Contrast Therapy
Alternating heat and cold — a vascular workout.
Ginger
6-gingerol, nausea, anti-inflammatory, relevance for sport.
Overtraining
Early warning signs, diagnosis, recovery strategies, hormone markers.
Stretching
Static vs. dynamic — timing, effects on performance and injury.