Hormone

TRTStudienlage & Dosis

Testosteron-Substitution als medizinisches Thema, Indikationen, Risiken.

Studienlage in Zahlen

Studien gesamt: 141
Mit Abstract: 48
Meta / Systematic / RCT: 6
Häufig zitiert: 17
Erscheinungsjahre: 1999–2026

TRT im Kontext von Hormone

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Top-Studien zu TRT

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

Adjuvant or early salvage radiotherapy for the treatment of localised and locally advanced prostate cancer: a prospectively planned systematic review and meta-analysis of aggregate data.
Lancet (London, England)2020n=2.153156 einflussreiche Zitationen
<h4>Background</h4>It is unclear whether adjuvant or early salvage radiotherapy following radical prostatectomy is more appropriate for men who present with localised or locally advanced prostate cancer. We aimed to prospectively plan a…
Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials.
The journals of gerontology. Series A, Biological sciences and medical sciences2005n=651152 einflussreiche Zitationen
<h4>Background</h4>We performed a meta-analysis of randomized clinical trials to determine the risks of adverse events associated with testosterone replacement in older men.<h4>Methods</h4>The MEDLINE database was searched from 1966 to…
Testosterone supplementation and bone parameters: a systematic review and meta-analysis study.
J Endocrinol Invest2022n=310Meta-Analysis60 einflussreiche Zitationen
<h4>Background</h4>The role of testosterone (T) replacement therapy (TRT) in subjects with late onset hypogonadism is still the object of an intense debate.<h4>Methods</h4>All observational studies and placebo-controlled or -uncontrolled…
Befund: Testosterone replacement therapy was associated with a significant reduction of bone resorption markers in observational studies but not in controlled studies.
A Systematic Review and Meta-analysis of the Effectiveness and Toxicities of Lutetium-177-labeled Prostate-specific Membrane Antigen-targeted Radioligand Therapy in Metastatic Castration-Resistant Prostate Cancer.
European urology2021n=1.19254 einflussreiche Zitationen
<h4>Context</h4>Castration-resistant prostate cancer (CRPC) treatment is an evolving challenge. Prostate-specific membrane antigen (PSMA)-targeted endoradiotherapy/radioligand therapy (PRLT) with small-molecule, urea-based agents labeled…
Association between testosterone replacement therapy and cardiovascular outcomes: A meta-analysis of 30 randomized controlled trials.
Prog Cardiovasc Dis2024n=11.502Meta-Analysis42 einflussreiche Zitationen
<h4>Background</h4>The Cardiovascular safety of testosterone replacement therapy (TRT) among men with hypogonadism is not well established to date. Hence, we sought to evaluate the cardiovascular disease (CVD) outcomes among patients…
Cardiovascular safety of testosterone replacement therapy in men: an updated systematic review and meta-analysis.
Expert Opin Drug Saf2024n=15.436Meta-Analysis40 einflussreiche Zitationen
<h4>Introduction</h4>The cardiovascular (CV) safety of testosterone (T) replacement therapy (TRT) is still conflicting. Recent data suggested a TRT-related increased risk of atrial fibrillation (AF). The aim of this study was to systematic…
An updated systematic review and meta-analysis of the effects of testosterone replacement therapy on erectile function and prostate.
Front Endocrinol (Lausanne)2024n=28Meta-Analysis39 einflussreiche Zitationen
<h4>Introduction</h4>Testosterone replacement therapy (TRT) is a generally accepted method treating for aging-related late-onset hypogonadism (LOH). However, the efficacy and safety of TRT remain controversial. An updated systematic review…
Testosterone replacement therapy and vascular thromboembolic events: a systematic review and meta-analysis.
Asian journal of andrology202433 einflussreiche Zitationen
To evaluate the relationship between testosterone replacement therapy (TRT) and arterial and/or venous thrombosis in patients with pre-treatment total testosterone (TT) <12 nmol l -1 , we performed a meta-analysis following the Population…
Cardiovascular Outcomes of Hypogonadal Men Receiving Testosterone Replacement Therapy: A Meta-analysis of Randomized Controlled Trials.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists2024n=94129 einflussreiche Zitationen
<h4>Objective</h4>To investigate the impact of testosterone replacement therapy (TRT) on cardiovascular outcomes in hypogonadal men.<h4>Methods</h4>A meta-analysis of 26 randomized controlled trials involving 10 941 participants was…
Effects of Exercise During Radiation Therapy on Physical Function and Treatment-Related Side Effects in Men With Prostate Cancer: A Systematic Review and Meta-Analysis.
International journal of radiation oncology, biology, physics202123 einflussreiche Zitationen
<h4>Purpose</h4>Radiation therapy is a commonly used treatment for prostate cancer; however, the side effects may negatively affect quality of life and cause patients to be less physically active. Although exercise has been shown to…

Häufige Fragen

Welche Dosierung wurde in den Studien untersucht?

• testosterone replacement • Testosterone replacement therapy (TRT) (Not reported)

Gibt es Sicherheitshinweise zu TRT?

• need to monitor hematocrit, PSA, and digital examination of the prostate during testosterone replacement in older men. • Not reported • Not reported in the abstract beyond cardiovascular outcomes. • Non-fatal arrhythmias and atrial fibrillation increased in the primary-endpoint trial.