Growth Hormone (GH/IGF-1)Studienlage & Dosis

Top-Studien zu Growth Hormone (GH/IGF-1)

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1. 01

   New insights on the cardiovascular effects of IGF-1.

   Front Endocrinol (Lausanne)·2023·n=4.000Systematic Review99 einflussreiche Zitationen

   Introduction Cardiovascular (CV) disorders are steadily increasing, making them the world’s most prevalent health issue. New research highlights the importance of insulin-like growth factor 1 (IGF-1) for maintaining CV health Methods We…

2. 02

   Real-world evidence of effectiveness and safety of pasireotide in the treatment of acromegaly: a systematic review and meta-analysis.

   Rev Endocr Metab Disord·2025·n=409Meta-Analysis66 einflussreiche Zitationen

   Pasireotide long-acting release (PAS-LAR) is a second-generation somatostatin receptor ligand (SRL) approved for acromegaly treatment. This meta-analysis aimed to evaluate the real-world effectiveness and safety of PAS-LAR in patients with…

   Befund: In this real-world meta-analysis, pasireotide long-acting release achieved IGF-1 control in 57.9% of patients with acromegaly.

3. 03

   Efficacy, safety, quality of life, adherence and cost-effectiveness of long-acting growth hormone replacement therapy compared to daily growth hormone in children with growth hormone deficiency: A systematic review and meta-analysis.

   Pharmacol Res·2023·n=16Meta-Analysis65 einflussreiche Zitationen

   We evaluated the efficacy, safety, adherence, quality of life (QoL) and cost-effectiveness of long-acting growth hormone (LAGH) vs daily growth hormone (GH) preparations in the treatment of growth hormone deficiency (GHD) in children.…

4. 04

   The influence of growth hormone on pediatric body composition: A systematic review.

   Front Endocrinol (Lausanne)·2023·n=16Systematic Review57 einflussreiche Zitationen

   Background Growth hormone (GH) affects metabolism and regulates growth in childhood. The most prominent feature of GH deficiency (GHD) in children is diminished height velocity that eventually leads to short stature. In adult-onset GHD,…

5. 05

   GH Therapy in Chronic Heart Failure: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

   J Clin Endocrinol Metab·2025·n=355Meta-Analysis50 einflussreiche Zitationen

   <h4>Context</h4>Guideline-directed medical therapy of heart failure (HF) primarily targets neurohormonal activation. However, GH has emerged as a potential treatment for the multiple hormonal deficiency syndrome, which is associated with…

6. 06

   The influence of growth and sex hormones on risk of alzheimer's disease: a mendelian randomization study.

   Eur J Epidemiol·2023·n=21.982Meta-Analysis47 einflussreiche Zitationen

   Alzheimer's disease is more prevalent in women, possibly due to sex or growth hormones but existing evidence is inconclusive. We investigated whether genetically predicted sex and growth hormones are associated with risk of Alzheimer's…

7. 07

   Identifying Potentially Modifiable Factors Associated with Treatment Non-Adherence in Paediatric Growth Hormone Deficiency: A Systematic Review.

   Horm Res Paediatr·2018Systematic Review44 einflussreiche Zitationen

   <b><i>Background:</i></b> Despite the developments of recombinant growth hormone (rhGH) treatment and the benefits in long-term clinical health outcomes, evidence has shown that many children with growth hormone deficiency (GHD) still fail…

8. 08

   Pegvisomant Improves Glucose Metabolism in Acromegaly: A Meta-Analysis of Prospective Interventional Studies.

   J Clin Endocrinol Metab·2019·n=550Meta-Analysis40 einflussreiche Zitationen

   <h4>Introduction</h4>Pegvisomant (PEG) in monotherapy or combined with somatostatin analogs (SSAs) is used to control acromegaly, improving metabolism. However, the metabolic changes induced by PEG have not been systematically…

   Befund: In patients with acromegaly, pegvisomant significantly decreased fasting plasma glucose, HbA1c, fasting plasma insulin, and HOMA-I.

9. 09

   The effect of resistance training on serum insulin-like growth factor 1(IGF-1): A systematic review and meta-analysis.

   Complement Ther Med·2020·n=33Meta-Analysis40 einflussreiche Zitationen

   <h4>Background</h4>Data about the effects of resistance exercise on level of IGF-1 in the serum are conflicting. To resolve this inconsistency, we performed a systematic review and meta-analysis to precisely examine the effects of…

10. 10

    Treatment Adherence to Injectable Treatments in Pediatric Growth Hormone Deficiency Compared With Injectable Treatments in Other Chronic Pediatric Conditions: A Systematic Literature Review.

    Front Endocrinol (Lausanne)·2022·n=23Systematic Review36 einflussreiche Zitationen

    Background Pediatric patients with growth hormone deficiency (GHD) are currently treated with daily injections of recombinant human growth hormone (rhGH) to promote linear growth and enable attainment of normal adult height. One of the…

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