Fasting Insulin & HOMA-IREvidence & Dosage

Top studies on Fasting Insulin & HOMA-IR

Ranked by influential-citation count and publication year.

1. 01

   Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.

   Diabetes care·1999·n=153200 influential citations

   <h4>Objective</h4>Several methods have been proposed to evaluate insulin sensitivity from the data obtained from the oral glucose tolerance test (OGTT). However, the validity of these indices has not been rigorously evaluated by comparing…

2. 02

   Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients.

   The Journal of clinical endocrinology and metabolism·2001172 influential citations

   To elucidate the causes of the diminished incretin effect in type 2 diabetes mellitus we investigated the secretion of the incretin hormones, glucagon-like peptide-1 and glucose- dependent insulinotropic polypeptide and measured…

3. 03

   A model-based method for assessing insulin sensitivity from the oral glucose tolerance test.

   Diabetes care·2001·n=38163 influential citations

   <h4>Objective</h4>Available insulin sensitivity (IS) methods based on the oral glucose tolerance test (OGTT) are empirical. We used a glucose-insulin model to derive an OGTT-based IS (oral glucose insulin sensitivity [OGIS]) index, which…

4. 04

   Diagnosing insulin resistance in the general population.

   Diabetes care·2001144 influential citations

   <h4>Objective</h4>Difficulties in measuring insulin sensitivity prevent the identification of insulin-resistant individuals in the general population. Therefore, we compared fasting insulin, homeostasis model assessment (HOMA),…

5. 05

   The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes.

   Diabetes·2002119 influential citations

   We examined the effect of three months of rosiglitazone treatment (4 mg b.i.d.) on whole-body insulin sensitivity and in vivo peripheral adipocyte insulin sensitivity as assessed by glycerol release in microdialysis from subcutaneous fat…

6. 06

   Homeostasis model assessment as a clinical index of insulin resistance in type 2 diabetic patients treated with sulfonylureas.

   Diabetes care·1999·n=80107 influential citations

   <h4>Objective</h4>To investigate whether the insulin resistance index (IR) assessed by homeostasis model assessment (HOMA) is associated with the insulin resistance index assessed by euglycemic-hyperinsulinemic clamp (clamp IR) in type 2…

7. 07

   Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents.

   The Journal of pediatrics·2004107 influential citations

   <h4>Objectives</h4>To compare insulin sensitivity and pancreatic beta-cell function measured by the euglycemic and the hyperglycemic clamp, with simple estimates of insulin sensitivity and pancreatic beta-cell function in youth. Study…

8. 08

   Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans.

   Diabetes·2002·n=47104 influential citations

   Adiponectin, the most abundant adipose-specific protein, has been found to be negatively associated with degree of adiposity and positively associated with insulin sensitivity in Pima Indians and other populations. Moreover, adiponectin…

9. 09

   Diagnosing insulin resistance by simple quantitative methods in subjects with normal glucose metabolism.

   Diabetes care·2003·n=6598 influential citations

   <h4>Objective</h4>To identify a reliable yet simple indirect method for detection of insulin resistance (IR).<h4>Research design and methods</h4>A total of 65 subjects (44 men and 21 women aged 30-60 years) were selected by a simple random…

10. 10

    Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus.

    The Journal of clinical endocrinology and metabolism·200398 influential citations

    Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretin hormones secreted in response to meal ingestion, thereby enhancing postprandial insulin secretion. Therefore, an attenuated incretin…