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PT-141 (Bremelanotide)Evidence & Dosage

Libido, Melanocortin pathway, and neurological effects.

Studies last updated

Evidence at a glance

Total studies
266
With abstract
50
Meta / Systematic / RCT
18
Highly cited
50
Publication years
1993–2026

PT-141 (Bremelanotide) in the context of Peptides

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Top studies on PT-141 (Bremelanotide)

Ranked by influential-citation count and publication year.

  1. Validation of the Female Sexual Function Index (FSFI) in women with female orgasmic disorder and in women with hypoactive sexual desire disorder.

    Journal of sex & marital therapy2003n=71158 influential citations

    The Female Sexual Functioning Index (FSFI; Rosen et al., 2000) is a self-report measure of sexual functioning that has been validated on a clinically diagnosed sample of women with female sexual arousal disorder. The present investigation…

  2. The Premature Ejaculation Prevalence and Attitudes (PEPA) survey: prevalence, comorbidities, and professional help-seeking.

    European urology2007n=12,133146 influential citations

    <h4>Objectives</h4>This study evaluated the associated comorbidities and patient satisfaction with treatment options for premature ejaculation (PE), a common sexual dysfunction.<h4>Methods</h4>A comprehensive, Internet-based survey (the PE…

  3. Prevalence of sexual dysfunction among newer antidepressants.

    The Journal of clinical psychiatry2002n=4,534123 influential citations

    <h4>Background</h4>Sexual dysfunction commonly occurs during antidepressant treatment. However, the reported rates of sexual dysfunction vary across antidepressants and are typically underreported in product literature. The objectives of…

  4. Hypoactive sexual desire disorder in postmenopausal women: US results from the Women's International Study of Health and Sexuality (WISHeS).

    Menopause (New York, N.Y.)2006115 influential citations

    <h4>Objective</h4>To determine the prevalence of hypoactive sexual desire disorder (HSDD) among US women by reproductive status and age and to explore the correlates of sexually related distress.<h4>Design</h4>The Women's International…

  5. Antidepressant-induced sexual dysfunction.

    The Annals of pharmacotherapy200273 influential citations

    <h4>Objective</h4>To review the evidence regarding antidepressant-induced sexual dysfunction and address implications for treatment strategy and health plan coverage policies for antidepressant medications.<h4>Data sources</h4>Primary…

  6. Efficacy and safety of sildenafil citrate in women with sexual dysfunction associated with female sexual arousal disorder.

    Journal of women's health &amp; gender-based medicine200265 influential citations

    <h4>Objective</h4>Sildenafil citrate (Viagra Pfizer, New York, NY) is indicated for the treatment of erectile dysfunction in men. The nitric oxide-cyclic guanosine monophosphate pathway (NO-cGMP) involved in penile erection and enhanced by…

  7. Prevalence and risk factors of sexual dysfunction in men and women.

    Current psychiatry reports200063 influential citations

    Sexual dysfunctions are highly prevalent, affecting about 43% of women and 31% of men. Hypoactive sexual desire disorder has been reported in approximately 30% of women and 15% of men in population-based studies, and is associated with a…

  8. Safety and efficacy of sildenafil in postmenopausal women with sexual dysfunction.

    Urology1999n=3359 influential citations

    <h4>Objectives</h4>Sildenafil has been demonstrated to be safe and effective in the treatment of men with erectile dysfunction. The role of sildenafil in treating women with sexual dysfunction has heretofore not been reported. The purpose…

  9. Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials.

    Obstet Gynecol2019n=1,267RCT53 influential citations

    OBJECTIVE: To evaluate the safety and efficacy of bremelanotide for the treatment of premenopausal women with hypoactive sexual desire disorder. METHODS: Two identical phase 3, randomized, double-blind, placebo-controlled, multicenter…

  10. Safety and efficacy of sildenafil citrate for the treatment of female sexual arousal disorder: a double-blind, placebo controlled study.

    The Journal of urology200352 influential citations

    <h4>Purpose</h4>We evaluated the efficacy and safety of sildenafil citrate in spontaneously or surgically postmenopausal women with female sexual arousal disorder (FSAD).<h4>Materials and methods</h4>Sildenafil (a 50 mg dose adjustable to…

Frequently asked

Are there safety considerations for PT-141 (Bremelanotide)?
• Nausea, flushing, and headache occurred in 10% or more of participants. • Most treatment-emergent adverse events were mild or moderate. • Adverse events were mainly tolerability-related.

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