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IpamorelinEvidence & Dosage

Selective GH releaser, cortisol‑sparing, and stack combinations.

Studies last updated

Evidence at a glance

Total studies
67
With abstract
48
Meta / Systematic / RCT
1
Highly cited
33
Publication years
1981–2026

Ipamorelin in the context of Peptides

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Top studies on Ipamorelin

Ranked by influential-citation count and publication year.

  1. Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration.

    Journal of medicinal chemistry2000128 influential citations

    A series of very potent derivatives of the 30-amino acid peptide hormone glucagon-like peptide-1 (GLP-1) is described. The compounds were all derivatized with fatty acids in order to protract their action by facilitating binding to serum…

  2. Conformational energy studies and in vitro and in vivo activity data on growth hormone-releasing peptides.

    Endocrinology198461 influential citations

    A series of growth hormone-releasing peptides have been designed and tested for both in vitro and in vivo activity. In vitro activity at 1-10 ng/ml was obtained for the pentapeptide, His-DTrp-Ala-Trp-DPhe-NH2 (I) and the hexapeptide,…

  3. Ghrelin: An Emerging Therapy for Heart Failure

    Clinical Endocrinology202555 influential citations

    <h4>Objective</h4>Ghrelin is emerging as a promising therapeutic option for heart failure (HF) due to its potent inotropic, anabolic, and cardioprotective properties. This review aims to critically examine the available clinical evidence…

  4. Design, synthesis, and biological activity of peptides which release growth hormone in vitro.

    Endocrinology198153 influential citations

    Experimental observations showed that the analogs [D-Trp2]- and [D-Phe2]methionine enkephalin amide were weakly active in releasing GH from rat pituitary in vitro. These observations were used to design more active GH-releasing factors.…

  5. Determination of growth hormone releasing peptides (GHRP) and their major metabolites in human urine for doping controls by means of liquid chromatography mass spectrometry.

    Analytical and bioanalytical chemistry2011E33 influential citations

    A family of small peptides has reached the focus of doping controls representing a comparably new strategy for cheating sportsmen. These growth hormone releasing peptides (GHRP) are orally active and induce an increased production of…

  6. Simplifying and expanding the screening for peptides <2 kDa by direct urine injection, liquid chromatography, and ion mobility mass spectrometry.

    Journal of separation science2016E23 influential citations

    The analysis of low-molecular-mass peptides in doping controls has become a mandatory aspect in sports drug testing and, thus, the number of samples that has to be tested for these analytes has been steadily increasing. Several peptides <2…

  7. Determination of prohibited, small peptides in urine for sports drug testing by means of nano-liquid chromatography/benchtop quadrupole orbitrap tandem-mass spectrometry.

    Journal of chromatography. A2012E21 influential citations

    In the present study, a screening assay was developed comprising 11 prohibited peptides (<1.5 kDa) that are sufficiently purified from urine using weak cation exchange with subsequent determination of all substances by means of nanoUHPLC…

  8. A high-throughput LC-MS/MS screen for GHRP in equine and human urine, featuring peptide derivatization for improved chromatography.

    Drug testing and analysis2014E21 influential citations

    The growth hormone releasing peptides (GHRPs) hexarelin, ipamorelin, alexamorelin, GHRP-1, GHRP-2, GHRP-4, GHRP-5, and GHRP-6 are all synthetic met-enkephalin analogues that include unnatural D-amino acids. They were designed specifically…

  9. Determination of IGF-1 and IGF-2, their degradation products and synthetic analogues in urine by LC-MS/MS.

    The Analyst201120 influential citations

    Peptide analysis in doping controls by means of nano-UPLC coupled high resolution/high mass accuracy mass spectrometry provides the state-of-the-art technique in modern sports drug testing. The present study describes a recent application…

  10. Metabolism of growth hormone releasing peptides.

    Analytical chemistry2012E20 influential citations

    New, potentially performance enhancing compounds have frequently been introduced to licit and illicit markets and rapidly distributed via worldwide operating Internet platforms. Developing fast analytical strategies to follow these new…

Frequently asked

Are there safety considerations for Ipamorelin?
• Single oral 10 mg GHRP-2 dose was used in the excretion study. • No adverse events were reported in the abstract. • Ipamorelin did not significantly increase ACTH or cortisol in swine, even at >200-fold the GH ED50. • No effects on FSH, LH, PRL, or TSH were observed in swine.

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