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Autoimmunity RiskEvidence & Dosage

Immune modulation can both promote tolerance and tip into dysregulation.

Evidence at a glance

Total studies
1,000
With abstract
48
Meta / Systematic / RCT
0
Highly cited
1
Publication years
1951–2026

Autoimmunity Risk in the context of Peptides

This topic is part of our "Peptides" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Autoimmunity Risk

Ranked by influential-citation count and publication year.

  1. Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study.

    European journal of nutrition2024n=8,500E19 influential citations

    The aim was to study the association between dietary intake of B vitamins in childhood and the risk of islet autoimmunity (IA) and progression to type 1 diabetes (T1D) by the age of 10 years. We followed 8500 T1D-susceptible children…

  2. The Impact of Thyroid Autoimmunity, Glucose Metabolism, and Vitamin D Status in Women With Recurrent Pregnancy Loss: A Retrospective Study.

    Endocrine, metabolic & immune disorders drug targets2026E

    The influence of thyroid autoimmunity (TAI) on obstetrical and fetal outcomes is debated. Specifically, the impact of thyroid antibodies on the risk of recurrent pregnancy loss (RPL) remains controversial. Similarly, the relationship…

  3. Regulatory T cells in the era of cell and gene therapy: biology, clinical translation, and future prospects.

    Frontiers in immunology2026D

    Regulatory T cells (Tregs) play a central role in maintaining immune homeostasis. Therefore, owing to their unique immunomodulatory function, their adoptive transfer has been investigated as a novel therapeutic modality. Recent progress in…

  4. Exposure to per- and polyfluoroalkyl substances (PFAS) and development of autoimmunity in humans and animals: a scoping review.

    Archives of toxicology2026

    PFAS are a group of persistent organic pollutants, that bioaccumulate and are associated with negative health effects. Reviews have suggested that the most critical effects of PFAS are on the immune system, but little is known of effects…

  5. The impact of pre-existing autoimmune diseases in myelodysplastic syndrome patients undergoing allogeneic hematopoietic stem cell transplantation: A retrospective cohort study.

    Clinical immunology (Orlando, Fla.)2026

    Myelodysplastic syndrome (MDS) is frequently accompanied by autoimmune diseases (AD), yet their combined impact on allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains controversial. We retrospectively studied 161 MDS…

  6. Global prevalence, site-specific patterns, and key risk factors for osteoporosis and bone loss in systemic lupus erythematosus: a systematic review and meta-analysis.

    Frontiers in immunology2026

    Background Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which patients have a significantly increased risk of developing osteoporosis (OP) and osteopenia. Despite numerous studies, the global burden of SLE-related…

  7. Genetic and epigenetic fine mapping of causal autoimmune disease variants

    Nature2014

    Genome-wide association studies have identified loci underlying human diseases, but the causal nucleotide changes and mechanisms remain largely unknown. Here we developed a fine-mapping algorithm to identify candidate causal variants for…

  8. A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA–DR (shared epitope)–restricted immune reactions to autoantigens modified by citrullination

    Arthritis & Rheumatism2005

    <h4>Objective</h4>To investigate whether smoking and HLA-DR shared epitope (SE) genes may interact in triggering immune reactions to citrulline-modified proteins.<h4>Methods</h4>In a case-control study involving patients with recent-onset…

  9. Subclinical Hypothyroidism Is an Independent Risk Factor for Atherosclerosis and Myocardial Infarction in Elderly Women: The Rotterdam Study

    Annals of Internal Medicine2000n=1,149

    <h4>Background</h4>Overt hypothyroidism has been found to be associated with cardiovascular disease. Whether subclinical hypothyroidism and thyroid autoimmunity are also risk factors for cardiovascular disease is…

  10. Common variable immunodeficiency disorders: division into distinct clinical phenotypes

    Blood2008n=9,461

    The European Common Variable Immunodeficiency Disorders registry was started in 1996 to define distinct clinical phenotypes and determine overlap within individual patients. A total of 7 centers contributed patient data, resulting in the…

Frequently asked

What dosage was studied?
• Dietary intake of B vitamins (niacin, pyridoxine, vitamin B12, riboflavin) from foods and dietary supplements

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