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Longevity

SarcopeniaEvidence & Dosage

Age-related muscle loss — strength training + protein are the best prevention.

Evidence at a glance

Total studies
1,000
With abstract
46
Meta / Systematic / RCT
2
Highly cited
15
Publication years
1991–2026

Sarcopenia in the context of Longevity

This topic is part of our "Longevity" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Sarcopenia

Ranked by influential-citation count and publication year.

  1. Epidemiology of sarcopenia among the elderly in New Mexico.

    American journal of epidemiology1998n=199200 influential citations

    Muscle mass decreases with age, leading to "sarcopenia," or low relative muscle mass, in elderly people. Sarcopenia is believed to be associated with metabolic, physiologic, and functional impairments and disability. Methods of estimating…

  2. Epidemiology of sarcopenia: Prevalence, risk factors, and consequences.

    Metabolism: clinical and experimental2023200 influential citations

    Sarcopenia is a geriatric condition featured by a progressive loss of muscle mass and function and associated with various adverse health outcomes. In this review, we aimed to summarize the epidemiological features of sarcopenia as well as…

  3. Osteosarcopenia: epidemiology, diagnosis, and treatment-facts and numbers.

    J Cachexia Sarcopenia Muscle2020n=235other200 influential citations

    BACKGROUND: Osteosarcopenia, the presence of osteopenia/osteoporosis and sarcopenia, is an emerging geriatric giant, which poses a serious global health burden. METHODS AND RESULTS: The prevalence of osteosarcopenia ranges in…

  4. Health outcomes of sarcopenia: a consensus report by the outcome working group of the Global Leadership Initiative in Sarcopenia (GLIS).

    Aging clinical and experimental research2025200 influential citations

    The Global Leadership Initiative in Sarcopenia (GLIS) aims to standardize the definition and diagnostic criteria for sarcopenia into one unifying, common classification. Among other actions to achieve this objective, the GLIS has organized…

  5. Diagnostic Criteria and Measurement Techniques of Sarcopenia: A Critical Evaluation of the Up-to-Date Evidence.

    Nutrients2024Review183 influential citations

    Sarcopenia, a geriatric syndrome characterized by progressive skeletal muscle mass and function decline, poses a significant health risk among the elderly, contributing to frailty, falls, hospitalization, loss of independence and…

  6. From mitochondria to sarcopenia: role of 17β-estradiol and testosterone.

    Front Endocrinol (Lausanne)2023Review58 influential citations

    Sarcopenia, characterized by a loss of muscle mass and strength with aging, is prevalent in older adults. Although the exact mechanisms underlying sarcopenia are not fully understood, evidence suggests that the loss of mitochondrial…

  7. Creatine supplementation for older adults: Focus on sarcopenia, osteoporosis, frailty and Cachexia.

    Bone2022review51 influential citations

    Sarcopenia refers to the age-related reduction in strength, muscle mass and functionality which increases the risk for falls, injuries and fractures. Sarcopenia is associated with other age-related conditions such as osteoporosis, frailty…

  8. Defining sarcopenia: some caveats and challenges.

    Curr Opin Clin Nutr Metab Care2020Review47 influential citations

    PURPOSE OF REVIEW: To summarize the latest advances and caveats in defining sarcopenia and discuss the implications of the most recent worldwide initiatives which are trying to harmonize the definition. RECENT FINDINGS: The evolution over…

  9. Nutritional strategies for improving sarcopenia outcomes in older adults: A narrative review.

    Pharmacol Res Perspect2024review46 influential citations

    Sarcopenia is characterized by a decline in muscle strength, generalized loss of skeletal muscle mass, and impaired physical performance, which are common outcomes used to screen, diagnose, and determine severity of sarcopenia in older…

  10. Sarcopenia--mechanisms and treatments.

    J Geriatr Phys Ther2009review25 influential citations

    BACKGROUND: Sarcopenia is a consequence of aging. This atrophic event is responsible for decrease in strength and associated functional deficits seen in the aging adult. PURPOSE: This paper reviews: (1) the mechanisms contributing to…

Frequently asked

What dosage was studied?
• None (Not applicable)
Which population does the evidence apply to?
Most studies investigated: unknown.
Are there safety considerations for Sarcopenia?
• No intervention or adverse events reported; review of observational data only. • None reported; review article. • Not reported; this is a review article. • Not reported in the abstract.

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