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Longevity

Biological AgeEvidence & Dosage

GrimAge, PhenoAge, DunedinPACE — what epigenetic clocks measure.

Evidence at a glance

Total studies
908
With abstract
37
Meta / Systematic / RCT
1
Highly cited
7
Publication years
1947–2027

Biological Age in the context of Longevity

This topic is part of our "Longevity" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Biological Age

Ranked by influential-citation count and publication year.

  1. Allostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging.

    Proceedings of the National Academy of Sciences of the United States of America2001n=1,189200 influential citations

    Allostatic load (AL) has been proposed as a new conceptualization of cumulative biological burden exacted on the body through attempts to adapt to life's demands. Using a multisystem summary measure of AL, we evaluated its capacity to…

  2. Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants.

    Nature communications2023200 influential citations

    Theory predicts that biological processes of aging may contribute to poor mental health in late life. To test this hypothesis, we evaluated prospective associations between biological age and incident depression and anxiety in 424,299 UK…

  3. A metabolomic profile of biological aging in 250,341 individuals from the UK Biobank.

    Nature communications2024n=95,372134 influential citations

    The metabolomic profile of aging is complex. Here, we analyse 325 nuclear magnetic resonance (NMR) biomarkers from 250,341 UK Biobank participants, identifying 54 representative aging-related biomarkers associated with all-cause mortality.…

  4. Dietary flavonoids intake contributes to delay biological aging process: analysis from NHANES dataset.

    Journal of translational medicine202388 influential citations

    Background Diet may influence biological aging and the discrepancy (∆age) between a subject’s biological age (BA) and chronological age (CA). We aimed to investigate the correlation of dietary flavonoids with the ∆age of organs (heart,…

  5. Systemic inflammation and biological aging in the Health and Retirement Study.

    GeroScience2023n=3,11376 influential citations

    Chronic, low-level systemic inflammation associated with aging, or inflammaging, is a risk factor for several chronic diseases and mortality. Using data from the Health and Retirement Study, we generated a continuous latent variable for…

  6. Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis.

    J Gerontol A Biol Sci Med Sci2017n=220RCT58 influential citations

    Biological aging measures have been proposed as proxies for extension of healthy life span in trials of geroprotective therapies that aim to slow aging. Several methods to measure biological aging show promise but it is not known if these…

  7. Adverse events in both childhood and adulthood are associated with molecular, clinical and functional markers of ageing.

    BMC medicine2026E

    Adverse events across the lifespan have been linked to poorer health outcomes, but the biological mechanisms remain unclear. The aim of this study was to quantify the independent and joint associations of adversity experienced in childhood…

  8. Synergistic impact of rest-activity circadian rhythms and physical activity on all-cause and cardiovascular mortality.

    The journals of gerontology. Series A, Biological sciences and medical sciences2026n=6,621E

    This study investigated the independent and joint associations of rest-activity circadian rhythms (RACRs) and physical activity (PA) with all-cause and cardiovascular mortality, and explored the potential role of accelerated biological…

  9. Depression and biological aging: Unexpected vulnerability in relatively advantaged social risk profile group.

    Acta psychologica2026n=18,787

    <h4>Background</h4>Depression has significantly associated with biological aging. Although lower social status is generally linked to increased vulnerability to aging, the biological impact of depression may differ according to social…

  10. Epigenetic Age Feedback as a Catalyst for Sustained Lifestyle Change: One-Year Results from the EU iHelp Study.

    Epigenomes2026n=178

    <h4>Background</h4>Sustaining long-term lifestyle change remains a major challenge in preventive health. Epigenetic clocks offer a dynamic, modifiable measure of biological ageing that may enhance motivation when returned to…

Frequently asked

Are there safety considerations for Biological Age?
• Not reported in the abstract.

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