HypertrophyEvidence & Dosage
Muscle-growth mechanisms, volume/intensity/frequency, protein timing.
Evidence at a glance
- Total studies
- 306
- With abstract
- 39
- Meta / Systematic / RCT
- 0
- Highly cited
- 1
- Publication years
- 1998–2026
Hypertrophy in the context of Performance
This topic is part of our "Performance" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to PerformanceTop studies on Hypertrophy
Ranked by influential-citation count and publication year.
Adiponectin-mediated modulation of hypertrophic signals in the heart.
Nature medicine2004n=2,004126 influential citationsPatients with diabetes and other obesity-linked conditions have increased susceptibility to cardiovascular disorders. The adipocytokine adiponectin is decreased in patients with obesity-linked diseases. Here, we found that pressure…
Detection of left ventricular hypertrophy through ECG: diagnostic performance and comparison of ten ECG scores in different hypertrophic conditions
European Journal of Internal Medicine2026n=4081 influential citations<h4>Background</h4>Different electrocardiographic (ECG) criteria were proposed to improve ECG-based detection of left ventricular hypertrophy (LVH), but external validation data are limited and their diagnostic performances in different…
Target systolic blood pressure in patients with left ventricular hypertrophy
European Journal of Internal Medicine2026n=9,1931 influential citationsLeft ventricular hypertrophy (LVH) is the most common hypertension-related cardiac disorder. Indeed, it is present in about 50% of patients with hypertension when examined by echocardiography and up to 20-30% when examined by…
TMC6 Is a Novel Therapeutic Target for Pathogenic Cardiac Hypertrophy
Circulation Research20261 influential citationsBACKGROUND: Pathogenic cardiac hypertrophy, often driven by mechanical stress, is a leading cause of heart failure. However, effective therapeutic targets remain limited. TMC6 (transmembrane channel-like protein 6) is abundant in healthy…
Sam68 Exacerbates Pathologic Cardiac Hypertrophy by Suppressing Cardiomyocyte Glucose Oxidation.
Circulation2026EMetabolic remodeling, marked by maladaptive shifts in substrate use and energy production, is a hallmark of pathologic cardiac hypertrophy. Yet the mechanisms linking stress signaling to impaired myocardial glucose oxidation remain…
BmooMPα-I ameliorates aortic fibrosis and hypertrophy in 2K1C hypertensive rats by reducing matrix metalloproteinase-2 activity
Toxicon2026Matrix metalloproteinase 2 (MMP-2) is the major MMP involved in hypertension and plays a central role in vascular remodeling in response to hemodynamic changes by promoting upregulation of transforming growth factor beta 1 (TGF-β1),…
E3 ubiquitin ligase RBX1 inhibits glutamine metabolism and attenuates cardiomyocyte hypertrophy
International Immunopharmacology2026Cardiac hypertrophy is an independent risk factor for cardiovascular disease, and with the progress of research, metabolic reprogramming has been recognized as a key mechanism in the development of several cardiac diseases. Recently,…
ALPK1 promotes cardiomyocyte hypertrophy by activating NF-κB/NLRP3 inflammasome-mediated pyroptosis
Experimental Cell Research2026<h4>Background</h4>Cardiac hypertrophy is a leading risk factor for cardiovascular morbidity and mortality. Alpha-protein kinase 1 (ALPK1) is a novel essential player in innate immunity and inflammation. Therapeutic agents targeting ALPK1…
ACSL6 alleviates myocardial hypertrophy by ameliorating cardiac lipid synthesis and mitochondrial function
Life Sciences2026<h4>Aims</h4>Myocardial hypertrophy is a key pathological basis for heart failure, closely related to disturbances in cardiac lipid metabolism and impaired mitochondrial function. Long-chain acyl-CoA synthetase 6 (ACSL6) is a pivotal…
COX-2–derived prostaglandins in cardiac hypertrophy: Dual roles in injury and repair
Prostaglandins & Other Lipid Mediators2026Cardiac hypertrophy represents a primary adaptive response of the heart to both mechanical stress and neurohormonal stimuli. However, beneficial hypertrophic adaptation eventually gives rise to maladaptive structural changes in the heart,…
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