Liver & DetoxificationEvidence & Dosage
Phase I/II detoxification, glutathione, alcohol — a critical look at "detox" myths.
Evidence at a glance
- Total studies
- 907
- With abstract
- 46
- Meta / Systematic / RCT
- 0
- Highly cited
- 3
- Publication years
- 1981–2026
Liver & Detoxification in the context of Vitamins & Minerals
This topic is part of our "Vitamins & Minerals" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to Vitamins & MineralsTop studies on Liver & Detoxification
Ranked by influential-citation count and publication year.
Targeted Down Regulation Of Core Mitochondrial Genes During SARS-CoV-2 Infection
bioRxiv2022n=1925 influential citationsDefects in mitochondrial oxidative phosphorylation (OXPHOS) have been reported in COVID-19 patients, but the timing and organs affected vary among reports. Here, we reveal the dynamics of COVID-19 through transcription profiles in…
Characteristics, Occurrence, Detection and Detoxification of Aflatoxins in Foods and Feeds
Foods20206 influential citationsMycotoxin contamination continues to be a food safety concern globally, with the most toxic being aflatoxins. On-farm aflatoxins, during food transit or storage, directly or indirectly result in the contamination of foods, which affects…
Chronic metabolic stress drives developmental programs and loss of tissue functions in non-transformed liver that mirror tumor states and stratify survival
bioRxiv20234 influential citationsUnder chronic stress, cells must balance competing demands between cellular survival and tissue function. In metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD/NASH), hepatocytes cooperate with structural and…
Role of the CLOCK protein in liver detoxification
British Journal of Pharmacology20193 influential citationsBackground and Purpose Whether and how circadian clock proteins regulate drug detoxification are not known. Here, we have assessed the effects of CLOCK (a core circadian clock protein) on drug metabolism and detoxification. Experimental…
Interference with the HNF4-dependent gene regulatory network diminishes ER stress in hepatocytes
bioRxiv20233 influential citationsIn all eukaryotic cell types, the unfolded protein response (UPR) upregulates factors that promote protein folding and misfolded protein clearance to help alleviate endoplasmic reticulum (ER) stress. Yet ER stress in the liver is uniquely…
CYP-mediated metabolic divergence underpins oxoglaucine selectivity: Detoxification in healthy hepatocytes versus mitochondrial apoptosis in hepatocellular carcinoma.
Toxicology in vitro : an international journal published in association with BIBRA20262 influential citationsOxoglaucine (OXO), an aporphine alkaloid derived from Corydalis yanhusuo, exhibits a broad spectrum of pharmacological activities, including antiviral, antifungal, antiplatelet, and anti-hepatic fibrosis effects, with particularly…
Glutathione supports lipid abundance <i>in vivo</i>
bioRxiv20232 influential citationsSUMMARY Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is implicated in…
Aflatoxin B1 in poultry liver: Toxic mechanism.
Toxicon20231 influential citationsAflatoxin B1 (AFB1) is the most common carcinogenic toxin in livestock and poultry feed, seriously endangering poultry production and public health. Liver is the most important organ for the metabolism of exogenous and endogenous…
A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes
Protein & Cell20231 influential citationsAging increases the risk of liver diseases and systemic susceptibility to aging-related diseases. However, cell type-specific changes and the underlying mechanism of liver aging in higher vertebrates remain incompletely characterized.…
Research Progress on the Protection and Detoxification of Phytochemicals against Aflatoxin B1-Induced Liver Toxicity.
Toxicon20211 influential citationsAflatoxin B<sub>1</sub> (AFB<sub>1</sub>) is a potent hepatotoxic toxin, which can cause hepatitis, cirrhosis, and liver immunological damage. It has been involved in the etiology of human hepatocellular carcinoma. AFB<sub>1</sub> can…
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