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Diagnostics & Biomarkers

Resting Heart RateEvidence & Dosage

A trend marker for cardiovascular fitness and overtraining.

Evidence at a glance

Total studies
702
With abstract
47
Meta / Systematic / RCT
2
Highly cited
3
Publication years
1988–2026

Resting Heart Rate in the context of Diagnostics & Biomarkers

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Top studies on Resting Heart Rate

Ranked by influential-citation count and publication year.

  1. Lower heart rate variability is associated with the development of coronary heart disease in individuals with diabetes: the atherosclerosis risk in communities (ARIC) study.

    Diabetes2002n=11,65462 influential citations

    The objective of this study was to test prospectively in a population sample whether individuals with impaired heart rate variability (HRV) are at increased risk of developing coronary heart disease (CHD) and of non-CHD mortality and to…

  2. Personal Pain Sensitivity Prediction from Ultra-short-term Resting Heart Rate Variability.

    Annu Int Conf IEEE Eng Med Biol Soc2022Study5 influential citations

    Pain is a subjective experience with interpersonal perception sensitivity differences. Pain sensitivity is of scientific and clinical interest, as it is a risk factor for several pain conditions. Resting heart rate variability (HRV) is a…

  3. Factors affecting resting heart rate in free-living healthy humans.

    Digit Health2022Study5 influential citations

    Resting heart rate (RHR) is a potential cardiac disease prevention target because it is strongly associated with cardiac morbidity and mortality, yet community-based monitoring of RHR remains in its infancy. Recently, smartwatches have…

  4. Exercise-based cardiac rehabilitation for adults with heart failure - 2023 Cochrane systematic review and meta-analysis.

    Eur J Heart Fail2023meta2 influential citations

    AIMS: Despite strong evidence, access to exercise-based cardiac rehabilitation (ExCR) remains low across global healthcare systems. We provide a contemporary update of the Cochrane review randomized trial evidence for ExCR for adults with…

  5. Autonomic and resting-state effective connectivity signatures of binge eating behavior.

    Neuroscience2026n=158Study1 influential citations

    Autonomic dysfunction, measured by heart rate variability (HRV) is implicated in the manifestation of binge eating (BE) behaviors. Aberrant resting-state functional connectivity among brain regions involved in reward processing, affect…

  6. Effects of Aerobic Exercise on Heart Rate Variability and C-Reactive Protein in Middle-Aged Adults With Normal Weight and Overweight/Obesity: A Pilot Study.

    Research in nursing & health2026E

    Aerobic exercise (AE) can improve heart rate variability (HRV) and reduce inflammation. Whether body mass index (BMI) affects physiological responses to AE remains unclear. This pilot study aimed to compare the effects of a 16-week AE on…

  7. Metabolic Health and Fitness Do Not Differ Substantially Between Overweight Adults With and Without α-Actinin-3 Deficiency.

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology2026n=80E

    The common ACTN3 R577X polymorphism leads to α-actinin-3 deficiency in ~20% of the human population and may be detrimental to their muscle power. However, the impact of ACTN3R577X on metabolic health and exercise capacity in the…

  8. The Social, Decoupled Self: Interpersonal Synchronization of Breathing Alters Intrapersonal Cardiorespiratory Coupling.

    Annals of the New York Academy of Sciences2026E

    People synchronize their behavioral and physiological rhythms with each other during social interaction. While interpersonal synchronization has largely been associated with positive effects such as social bonding, some evidence suggests…

  9. Dynamic aortic stiffness response to exercise as a marker of functional capacity in early-stage heart failure.

    Clinical physiology and functional imaging2026n=42E

    Aortic stiffness increases ventricular afterload and limits exercise capacity in heart failure (HF), but its dynamic response to exercise remains insufficiently defined. This study aimed to evaluate exercise-induced changes in aortic…

  10. Short-term effects of weight-loading on heart rate variability in obese adults.

    Physiological reports2026B

    Weight-loading reduces body fat, but its effects on cardiac autonomic modulation remain unclear. We examined heart rate variability (HRV) during free-living weight-loading in adults with class I obesity. Fifty-one participants (27 females)…

Frequently asked

What dosage was studied?
• Ultra-short-term resting heart rate variability features used to predict pain sensitivity (none) • Not applicable; observational analysis of smartwatch-derived resting heart rate and related activity/fitness measures (Not applicable)
Which population does the evidence apply to?
Most studies investigated: unknown.
Are there safety considerations for Resting Heart Rate?
• Not reported

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