Back to Vitamins & Minerals
Vitamins & Minerals

Animal vs Human StudiesEvidence & Dosage

Mouse ≠ human — translatability from resveratrol to rapamycin is shaky.

Evidence at a glance

Total studies
1,000
With abstract
46
Meta / Systematic / RCT
1
Highly cited
3
Publication years
1967–2026

Animal vs Human Studies in the context of Vitamins & Minerals

This topic is part of our "Vitamins & Minerals" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

Go to Vitamins & Minerals

Top studies on Animal vs Human Studies

Ranked by influential-citation count and publication year.

  1. Death by hyperventilation: a common and life-threatening problem during cardiopulmonary resuscitation.

    Critical care medicine2004130 influential citations

    <h4>Context</h4>This translational research initiative focused on the physiology of cardiopulmonary resuscitation (CPR) initiated by a clinical observation of consistent hyperventilation by professional rescuers in out-of-hospital cardiac…

  2. Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy.

    Journal of the American College of Cardiology200287 influential citations

    <h4>Objectives</h4>The purpose of this study was to determine whether patients with idiopathic dilated cardiomyopathy (IDCM) exhibit alterations in myocardial fatty acid and glucose metabolism.<h4>Background</h4>Alterations in myocardial…

  3. A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease.

    Nutrition &amp; metabolism2005n=5,38655 influential citations

    <h4>Background</h4>Alzheimer's disease (AD) is a progressive neurodegenerative disorder that primarily strikes the elderly. Studies in both humans and animal models have linked the consumption of cholesterol and saturated fats with…

  4. Integrative transcriptomic profiling links telomere dysfunction to cGAS-STING activation in heart failure signatures in mice and humans.

    Cardiovascular research2026n=221E1 influential citations

    Cardiomyocyte telomere shortening is evident during heart failure pathogenesis. Conversely, mice with engineered telomerase deficiency develop myocardial dysfunction accompanied by p53 activation and mitochondrial repression. We aimed to…

  5. Back to the Future: Repurposing Metformin, a Metabolically Active Drug, to Treat Mild-to-Moderate Ulcerative Colitis.

    Metabolites2026D

    The incidence of ulcerative colitis, an entity belonging to the inflammatory bowel diseases, is rising worldwide. Due to the unpredictable nature of its clinical flares and the need for chronic treatment, ulcerative colitis has a huge…

  6. Carnivore Diet: A Scoping Review of the Current Evidence, Potential Benefits and Risks.

    Nutrients2026D

    Background: The Carnivore Diet (CD) is an almost exclusively animal-based dietary pattern that has gained increasing popularity on social media. Despite numerous health-related claims, a standardized definition is lacking, and scientific…

  7. Effects of 52-Day Oral Exposure to Fluorescent Polystyrene Microplastics on Hormonal Profile, Sperm Parameters, and Fertility in Male Wistar Rats.

    Toxics2026n=18E

    Increasing environmental contamination with microplastics (MPs) raises significant concerns regarding their potential impact on reproductive health. This study evaluated the effects of prolonged oral exposure to fluorescent polystyrene…

  8. Therapeutic peptides in gerontology: mechanisms and applications for healthy aging.

    Frontiers in aging2026n=20D

    <h4>Background</h4>Peptide therapeutics represent an emerging frontier in gerontological medicine, targeting fundamental hallmarks of aging including metabolic dysfunction, telomere attrition, tissue repair impairment, and hormonal…

  9. Translatability of a miniature pig model to predict subcutaneous clinical injection times with a high-volume auto-injector and recombinant human hyaluronidase.

    Drug delivery and translational research2026

    Miniature pigs are an established preclinical model for subcutaneous (SC) drug administration; however, research on the direct translatability of this model is limited. This post hoc analysis of preclinical and clinical data assessed the…

  10. The effects, mechanisms, and influencing factors of concurrent strength and endurance training with different sequences: a semi-systematic review.

    Frontiers in sports and active living2025n=128D

    This study investigated how the sequencing of strength and endurance training affects athletic performance, and delved into the underlying mechanisms from the perspectives of neuromuscular and molecular adaptations. Furthermore, factors…

Frequently asked

Are there safety considerations for Animal vs Human Studies?
• FDA-approved agents had robust safety profiles in large-scale trials. • Investigational peptides lacked long-term safety data.

More topics in Vitamins & Minerals

Magnesium

Magnesium types, sleep, cramps, stress, and dosage.

Creatine Monohydrate

Power, muscle building, cognition, and safety of creatine.

Ashwagandha

Stress, sleep, cortisol, and possible side effects.

Melatonin Optimization

Melatonin needs, dosing (0.3-5 mg), extended-release forms, circadian rhythm, and long-term safety considerations.

Caffeine + L-Theanine

Caffeine, L-Theanine, focus, alertness and tolerance.

NAD+ Precursors

NMN, NR, NAD+, aging biology and evidence landscape.

Omega-3 Fatty Acids

EPA, DHA, ALA: daily needs, sources (fish, algae), Omega-3 index as biomarker, and cardiovascular RCT data.

Vitamin Optimization

Vitamin optimization strategies: needs assessment, bioavailability, synergies, and safety upper limits for the most relevant micronutrients.

Melatonin Signaling

Melatonin as a multi-system hormone: antioxidant, immunomodulatory, mitochondrial, and neuroprotective effects beyond sleep.

Bias

Sponsorship, selection bias, confirmation bias, industry funding.

Cardiovascular System

Blood pressure, heart rate, endothelium, cholesterol, cardiovascular risk factors.

Contraindications

When something must NOT be taken: pregnancy, pre-existing conditions.

Coenzyme Q10 (CoQ10 / Ubiquinol)

Mitochondria, statins, energy, and cardiovascular outcomes.

Correlation vs Causation

The classic misinterpretation of popular health studies.

Curcumin

Inflammation, bioavailability (piperine), turmeric extracts, and clinical outcomes.

Digestive System

Stomach acid, enzymes, absorption, the gut-brain axis, the microbiome.

Effect Size

p-value vs. practical relevance, Cohen's d, confidence intervals.

Ferritin & Iron

Ferritin, transferrin saturation, iron deficiency vs. iron overload.

Glutathione

Master antioxidant, liposomal vs. NAC forms and detoxification.

Immune System

Innate vs. adaptive immunity, inflammation, autoimmunity.

Related topics from other worlds

Peptides

Ipamorelin

Selective GH releaser, cortisol‑sparing, and stack combinations.

Peptides

Peptide Therapy

Automatisch via Trend Scout entdeckt. Mainstreaming for recovery and tissue repair in performance and longevity communities.. PubMed: 305 Ergebnisse.

Peptides

Semax

A Russian nootropic, BDNF increase, administered nasally.

Peptides

WADA/Doping

The list of banned substances — GH releasers, IGF-1, erythropoietin and more.

Performance

Citrulline Malate

NO precursor, pump and endurance studies.

Performance

Endurance

Aerobic base, lactate threshold, VO2max, polarized training.