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Peptide TherapyEvidence & Dosage

Automatisch via Trend Scout entdeckt. Mainstreaming for recovery and tissue repair in performance and longevity communities.. PubMed: 305 Ergebnisse.

Studies last updated

Evidence at a glance

Total studies
303
With abstract
50
Meta / Systematic / RCT
57
Highly cited
50
Publication years
1992–2026

Peptide Therapy in the context of Peptides

This topic is part of our "Peptides" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Peptide Therapy

Ranked by influential-citation count and publication year.

  1. Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist.

    Sci Transl Med2018RCT184 influential citations

    An orally delivered GLP-1 analog coformulated with the absorption enhancer SNAC achieves transcellular-directed absorption in the stomach.

  2. Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial.

    Lancet2001n=35RCT81 influential citations

    <h4>Background</h4>Type 1 diabetes results from autoimmune destruction of insulin-producing pancreatic beta cells. The 60 kDa heat-shock protein (hsp60) is one of the known target self antigens. An immunomodulatory peptide from hsp60,…

  3. Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models.

    PLoS One2013RCT67 influential citations

    Obesity is important for the development of type-2 diabetes as a result of obesity-induced insulin resistance accompanied by impaired compensation of insulin secretion from pancreatic beta cells. Here, based on a randomized pilot clinical…

  4. Safety and efficacy of oral octreotide in acromegaly: results of a multicenter phase III trial.

    J Clin Endocrinol Metab2015n=102Clinical Trial65 influential citations

    <h4>Background</h4>A novel oral octreotide formulation was tested for efficacy and safety in a phase III, multicenter, open-label, dose-titration, baseline-controlled study in patients with acromegaly.<h4>Methods</h4>We enrolled 155…

  5. Natriuretic peptides enhance the production of adiponectin in human adipocytes and in patients with chronic heart failure.

    J Am Coll Cardiol2009n=30RCT60 influential citations

    <h4>Objectives</h4>We investigated the functional relationship between natriuretic peptides and adiponectin by performing both experimental and clinical studies.<h4>Background</h4>Natriuretic peptides are promising candidates for the…

  6. Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins.

    Acta Pharm Sin B2019Review55 influential citations

    In last few years, therapeutic peptides/proteins are rapidly growing in drug market considering their higher efficiency and lower toxicity than chemical drugs. However, the administration of therapeutic peptides/proteins is mainly limited…

  7. Meta-iAVP: A Sequence-Based Meta-Predictor for Improving the Prediction of Antiviral Peptides Using Effective Feature Representation.

    Int J Mol Sci2019Study55 influential citations

    In spite of the large-scale production and widespread distribution of vaccines and antiviral drugs, viruses remain a prominent human disease. Recently, the discovery of antiviral peptides (AVPs) has become an influential antiviral agent…

  8. Beneficial effects of C-peptide on incipient nephropathy and neuropathy in patients with Type 1 diabetes mellitus.

    Diabet Med2000n=21RCT54 influential citations

    <h4>Aims</h4>Recent studies have indicated that proinsulin C-peptide shows specific binding to cell membrane binding sites and may exert biological effects when administered to patients with Type 1 diabetes mellitus. This study was…

  9. Peptide-Based Strategies Against Mycobacterium tuberculosis Covering Immunomodulation, Vaccines, Synergistic Therapy, and Nanodelivery.

    Pharmaceuticals (Basel)2025Review40 influential citations

    Tuberculosis (TB), caused by <i>Mycobacterium tuberculosis</i> (MTB), remains one of the most devastating infectious diseases worldwide, with rising multidrug resistance limiting the effectiveness of conventional treatments. Novel…

  10. Biomedical applications of synthetic peptides derived from venom of animal origin: A systematic review.

    Biomed Pharmacother2024Systematic Review37 influential citations

    Development of therapeutic agents that have fewer adverse effects and have higher efficacy for diseases, such as cancer, metabolic disorders, neurological diseases, infections, cardiovascular diseases, and respiratory diseases, are…

Frequently asked

What dosage was studied?
• Oral semaglutide tablet coformulated with SNAC (not reported) • DiaPep277 (heat-shock protein peptide p277) (1 mg p277 + 40 mg mannitol in vegetable oil, subcutaneous injection) • Intranasal oxytocin; mouse studies also used oxytocin, [Ser4, Ile8]-oxytocin, and [Asu1,6]-oxytocin (Not reported)
Are there safety considerations for Peptide Therapy?
• Not reported in the abstract. • No adverse effects were noted. • Not reported • Not reported.

More topics in Peptides

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Subcutaneous, intramuscular, nasal, oral, topical — bioavailability and safety.

Autoimmunity Risk

Immune modulation can both promote tolerance and tip into dysregulation.

BPC-157

Peptide for tissue regeneration, healing, and athletic recovery.

Cerebrolysin

A pig-brain peptide mix, stroke studies, not approved in Germany.

CJC-1295

GHRH analog, half‑life variants and pulse patterns.

Dihexa

Angiotensin derivative, cognitive/neuroplasticity signals in animal models.

GHK-Cu

Copper peptide for skin health, anti-aging, and wound healing.

GHRP-2

GH releaser, older generation, appetite stimulation as a side effect.

GHRP-6

GH releaser with a strong appetite component.

GLP-1 Rebound

Weight regain after stopping without lifestyle anchors.

GLP-1 Side Effects

Nausea, gastric emptying, muscle loss, pancreatitis risk.

Hexarelin

GH releaser, fast tolerance build-up, cardiac signals.

IGF-1 LR3

Modified IGF-1 with a long half-life — hypertrophy, the cancer-risk debate.

Immune Modulation

Automatisch via Trend Scout entdeckt. Supplements targeting inflammation and immune resilience remain a central research area.. PubMed: 11956 Ergebnisse.

Injection Safety

Sterile technique, bacteriostatic water, skin disinfection — a medical topic.

Ipamorelin

Selective GH releaser, cortisol‑sparing, and stack combinations.

KPV

An alpha-MSH fragment — anti-inflammatory, gut, skin, early research.

Liraglutide

First-generation GLP-1 for diabetes/obesity — daily, smaller effect size.

LL-37

Antimicrobial peptide, wound healing, immune modulation, early research.

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Clinical applications, hype, off-label risks abroad.

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Adenosine antagonism, individual sensitivity, cut-off strategies.

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EMDR / Trauma Therapy

PTSD, eye movements, and study effectiveness.

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Lavender

Silexan studies, oral and olfactory — anxiolysis with a good safety profile.

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Polyvagal Theory

Popular but scientifically contested — strengths and weaknesses.