Peptide TherapyStudienlage & Dosis

Top-Studien zu Peptide Therapy

Sortiert nach einflussreichen Zitationen (Semantic Scholar) und Erscheinungsjahr.

1. 01

   Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist.

   Sci Transl Med·2018RCT184 einflussreiche Zitationen

   An orally delivered GLP-1 analog coformulated with the absorption enhancer SNAC achieves transcellular-directed absorption in the stomach.

2. 02

   Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial.

   Lancet·2001·n=35RCT81 einflussreiche Zitationen

   <h4>Background</h4>Type 1 diabetes results from autoimmune destruction of insulin-producing pancreatic beta cells. The 60 kDa heat-shock protein (hsp60) is one of the known target self antigens. An immunomodulatory peptide from hsp60,…

3. 03

   Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models.

   PLoS One·2013RCT67 einflussreiche Zitationen

   Obesity is important for the development of type-2 diabetes as a result of obesity-induced insulin resistance accompanied by impaired compensation of insulin secretion from pancreatic beta cells. Here, based on a randomized pilot clinical…

4. 04

   Safety and efficacy of oral octreotide in acromegaly: results of a multicenter phase III trial.

   J Clin Endocrinol Metab·2015·n=102Clinical Trial65 einflussreiche Zitationen

   <h4>Background</h4>A novel oral octreotide formulation was tested for efficacy and safety in a phase III, multicenter, open-label, dose-titration, baseline-controlled study in patients with acromegaly.<h4>Methods</h4>We enrolled 155…

5. 05

   Natriuretic peptides enhance the production of adiponectin in human adipocytes and in patients with chronic heart failure.

   J Am Coll Cardiol·2009·n=30RCT60 einflussreiche Zitationen

   <h4>Objectives</h4>We investigated the functional relationship between natriuretic peptides and adiponectin by performing both experimental and clinical studies.<h4>Background</h4>Natriuretic peptides are promising candidates for the…

6. 06

   Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins.

   Acta Pharm Sin B·2019Review55 einflussreiche Zitationen

   In last few years, therapeutic peptides/proteins are rapidly growing in drug market considering their higher efficiency and lower toxicity than chemical drugs. However, the administration of therapeutic peptides/proteins is mainly limited…

7. 07

   Meta-iAVP: A Sequence-Based Meta-Predictor for Improving the Prediction of Antiviral Peptides Using Effective Feature Representation.

   Int J Mol Sci·2019Study55 einflussreiche Zitationen

   In spite of the large-scale production and widespread distribution of vaccines and antiviral drugs, viruses remain a prominent human disease. Recently, the discovery of antiviral peptides (AVPs) has become an influential antiviral agent…

8. 08

   Beneficial effects of C-peptide on incipient nephropathy and neuropathy in patients with Type 1 diabetes mellitus.

   Diabet Med·2000·n=21RCT54 einflussreiche Zitationen

   <h4>Aims</h4>Recent studies have indicated that proinsulin C-peptide shows specific binding to cell membrane binding sites and may exert biological effects when administered to patients with Type 1 diabetes mellitus. This study was…

9. 09

   Peptide-Based Strategies Against Mycobacterium tuberculosis Covering Immunomodulation, Vaccines, Synergistic Therapy, and Nanodelivery.

   Pharmaceuticals (Basel)·2025Review40 einflussreiche Zitationen

   Tuberculosis (TB), caused by <i>Mycobacterium tuberculosis</i> (MTB), remains one of the most devastating infectious diseases worldwide, with rising multidrug resistance limiting the effectiveness of conventional treatments. Novel…

10. 10

    Biomedical applications of synthetic peptides derived from venom of animal origin: A systematic review.

    Biomed Pharmacother·2024Systematic Review37 einflussreiche Zitationen

    Development of therapeutic agents that have fewer adverse effects and have higher efficacy for diseases, such as cancer, metabolic disorders, neurological diseases, infections, cardiovascular diseases, and respiratory diseases, are…

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