DihexaStudienlage & Dosis

Top-Studien zu Dihexa

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

1. 01

   Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors.

   Nature·2011147 einflussreiche Zitationen

   The generation of functional hepatocytes independent of donor liver organs is of great therapeutic interest with regard to regenerative medicine and possible cures for liver disease. Induced hepatic differentiation has been achieved…

2. 02

   The Brain Hepatocyte Growth Factor/c-Met Receptor System: A New Target for the Treatment of Alzheimer's Disease

   Journal of Alzheimer's Disease·2015

   Alzheimer's disease (AD) is a progressive neurodegenerative disease increasing in frequency as life expectancy of the world's population increases. There are an estimated 5 million diagnosed AD patients in the U.S. and 16 million worldwide…

3. 03

   Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens.

   Cell research·2019·n=7.459

   The study of pathophysiological mechanisms in human liver disease has been constrained by the inability to expand primary hepatocytes in vitro while maintaining proliferative capacity and metabolic function. We and others have previously…

4. 04

   Scalable production of tissue-like vascularized liver organoids from human PSCs

   Experimental & Molecular Medicine·2023

   The lack of physiological parity between 2D cell culture and in vivo culture has led to the development of more organotypic models, such as organoids. Organoid models have been developed for a number of tissues, including the liver.…

5. 05

   Evaluation of Metabolically Stabilized Angiotensin IV Analogs as Procognitive/Antidementia Agents

   Journal of Pharmacology and Experimental Therapeutics·2012

   Angiotensin IV (AngIV: VYIHPF)-related peptides have long been recognized as procognitive agents with potential as antidementia therapeutics. Their development as useful therapeutics, however, has been limited by physiochemical properties…

6. 06

   Pluripotent stem cells to hepatocytes, the journey so far

   Biomedical Reports·2017

   Over the past several years, there has been substantial progress in the field of regenerative medicine, which has enabled new possibilities for research and clinical application. For example, there are ongoing efforts directed at…

7. 07

   Small‐Molecule‐Directed Hepatocyte‐Like Cell Differentiation of Human Pluripotent Stem Cells

   Current Protocols in Stem Cell Biology·2016

   Hepatocyte‐like cells (HLCs) generated in vitro from human pluripotent stem cells (hPSCs) provide an invaluable resource for basic research, regenerative medicine, drug screening, toxicology, and modeling of liver disease and development.…

8. 08

   Development of a rapid screen for the endodermal differentiation potential of human pluripotent stem cell lines

   Scientific Reports·2016

   A challenge facing the human pluripotent stem cell (hPSC) field is the variability observed in differentiation potential of hPSCs. Variability can lead to time consuming and costly optimisation to yield the cell type of interest. This is…

9. 09

   Hepatocyte-like cells derived from human induced pluripotent stem cells using small molecules: implications of a transcriptomic study

   Stem Cell Research & Therapy·2020

   Background Hepatocyte-like cells (HLCs) derived from human induced pluripotent stem cells (iPSCs) hold great promise in toxicological applications as well as in regenerative medicine. Previous efforts on hepatocyte differentiation have…

10. 10

    Robust expansion and functional maturation of human hepatoblasts by chemical strategy

    Stem Cell Research & Therapy·2021

    Background Chemically strategies to generate hepatic cells from human pluripotent stem cells (hPSCs) for the potential clinical application have been improved. However, producing high quality and large quantities of hepatic cells remain…