IpamorelinStudienlage & Dosis

Top-Studien zu Ipamorelin

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

1. 01

   Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration.

   Journal of medicinal chemistry·2000128 einflussreiche Zitationen

   A series of very potent derivatives of the 30-amino acid peptide hormone glucagon-like peptide-1 (GLP-1) is described. The compounds were all derivatized with fatty acids in order to protract their action by facilitating binding to serum…

2. 02

   Conformational energy studies and in vitro and in vivo activity data on growth hormone-releasing peptides.

   Endocrinology·198461 einflussreiche Zitationen

   A series of growth hormone-releasing peptides have been designed and tested for both in vitro and in vivo activity. In vitro activity at 1-10 ng/ml was obtained for the pentapeptide, His-DTrp-Ala-Trp-DPhe-NH2 (I) and the hexapeptide,…

3. 03

   Ghrelin: An Emerging Therapy for Heart Failure

   Clinical Endocrinology·202555 einflussreiche Zitationen

   <h4>Objective</h4>Ghrelin is emerging as a promising therapeutic option for heart failure (HF) due to its potent inotropic, anabolic, and cardioprotective properties. This review aims to critically examine the available clinical evidence…

4. 04

   Design, synthesis, and biological activity of peptides which release growth hormone in vitro.

   Endocrinology·198153 einflussreiche Zitationen

   Experimental observations showed that the analogs [D-Trp2]- and [D-Phe2]methionine enkephalin amide were weakly active in releasing GH from rat pituitary in vitro. These observations were used to design more active GH-releasing factors.…

5. 05

   Determination of growth hormone releasing peptides (GHRP) and their major metabolites in human urine for doping controls by means of liquid chromatography mass spectrometry.

   Analytical and bioanalytical chemistry·2011E33 einflussreiche Zitationen

   A family of small peptides has reached the focus of doping controls representing a comparably new strategy for cheating sportsmen. These growth hormone releasing peptides (GHRP) are orally active and induce an increased production of…

6. 06

   Simplifying and expanding the screening for peptides <2 kDa by direct urine injection, liquid chromatography, and ion mobility mass spectrometry.

   Journal of separation science·2016E23 einflussreiche Zitationen

   The analysis of low-molecular-mass peptides in doping controls has become a mandatory aspect in sports drug testing and, thus, the number of samples that has to be tested for these analytes has been steadily increasing. Several peptides <2…

7. 07

   Determination of prohibited, small peptides in urine for sports drug testing by means of nano-liquid chromatography/benchtop quadrupole orbitrap tandem-mass spectrometry.

   Journal of chromatography. A·2012E21 einflussreiche Zitationen

   In the present study, a screening assay was developed comprising 11 prohibited peptides (<1.5 kDa) that are sufficiently purified from urine using weak cation exchange with subsequent determination of all substances by means of nanoUHPLC…

8. 08

   A high-throughput LC-MS/MS screen for GHRP in equine and human urine, featuring peptide derivatization for improved chromatography.

   Drug testing and analysis·2014E21 einflussreiche Zitationen

   The growth hormone releasing peptides (GHRPs) hexarelin, ipamorelin, alexamorelin, GHRP-1, GHRP-2, GHRP-4, GHRP-5, and GHRP-6 are all synthetic met-enkephalin analogues that include unnatural D-amino acids. They were designed specifically…

9. 09

   Determination of IGF-1 and IGF-2, their degradation products and synthetic analogues in urine by LC-MS/MS.

   The Analyst·201120 einflussreiche Zitationen

   Peptide analysis in doping controls by means of nano-UPLC coupled high resolution/high mass accuracy mass spectrometry provides the state-of-the-art technique in modern sports drug testing. The present study describes a recent application…

10. 10

    Metabolism of growth hormone releasing peptides.

    Analytical chemistry·2012E20 einflussreiche Zitationen

    New, potentially performance enhancing compounds have frequently been introduced to licit and illicit markets and rapidly distributed via worldwide operating Internet platforms. Developing fast analytical strategies to follow these new…

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