LL-37Evidence & Dosage
Antimicrobial peptide, wound healing, immune modulation, early research.
Evidence at a glance
- Total studies
- 100
- With abstract
- 16
- Meta / Systematic / RCT
- 0
- Highly cited
- 9
- Publication years
- 1998–2026
LL-37 in the context of Peptides
This topic is part of our "Peptides" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to PeptidesTop studies on LL-37
Ranked by influential-citation count and publication year.
An angiogenic role for the human peptide antibiotic LL-37/hCAP-18.
The Journal of clinical investigation2003169 influential citationsAntimicrobial peptides are effector molecules of the innate immune system and contribute to host defense and regulation of inflammation. The human cathelicidin antimicrobial peptide LL-37/hCAP-18 is expressed in leukocytes and epithelial…
LL-37: Structures, Antimicrobial Activity, and Influence on Amyloid-Related Diseases.
Biomolecules2024153 influential citationsAntimicrobial peptides (AMPs), as well as host defense peptides (HDPs), constitute the first line of defense as part of the innate immune system. Humans are known to express antimicrobial precursor proteins, which are further processed to…
Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8.
The Journal of experimental medicine2009n=11135 influential citationsDendritic cell (DC) responses to extracellular self-DNA and self-RNA are prevented by the endosomal seclusion of nucleic acid-recognizing Toll-like receptors (TLRs). In psoriasis, however, plasmacytoid DCs (pDCs) sense self-DNA that is…
Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity.
The Biochemical journal1999124 influential citationsThe antimicrobial peptide LL-37 belongs to the cathelicidin family and is the first amphipathic alpha-helical peptide isolated from human. LL-37 is considered to play an important role in the first line of defence against local infection…
Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles.
The Journal of biological chemistry2008107 influential citationsAs a key component of the innate immunity system, human cathelicidin LL-37 plays an essential role in protecting humans against infectious diseases. To elucidate the structural basis for its targeting bacterial membrane, we have determined…
Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases.
Antimicrobial agents and chemotherapy2004106 influential citationsCathelicidin LL-37 is one of the few human bactericidal peptides with potent antistaphylococcal activity. In this study we examined the susceptibility of LL-37 to proteolytic degradation by two major proteinases produced by Staphylococcus…
Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils.
Antimicrobial agents and chemotherapy199842 influential citationsHuman neutrophils contain two structurally distinct types of antimicrobial peptides, beta-sheet defensins (HNP-1 to HNP-4) and the alpha-helical peptide LL-37. We used radial diffusion assays and an improved National Committee for Clinical…
The Potential of Human Peptide LL-37 as an Antimicrobial and Anti-Biofilm Agent.
Antibiotics (Basel, Switzerland)20216 influential citationsThe rise in antimicrobial resistant bacteria threatens the current methods utilized to treat bacterial infections. The development of novel therapeutic agents is crucial in avoiding a post-antibiotic era and the associated deaths from…
Wound healing activity of the human antimicrobial peptide LL37.
Peptides20114 influential citationsAntimicrobial peptides (AMPs) are part of the innate immune system and are generally defined as cationic, amphipathic peptides, with less than 50 amino acids, including multiple arginine and lysine residues. The human cathelicidin…
Antimicrobial peptide LL-37 promotes bacterial phagocytosis by human macrophages.
Journal of leukocyte biology20144 influential citationsLL-37/hCAP-18 is the only human member of the cathelicidin family and plays an important role in killing various pathogens, as well as in immune modulation. In this study, we investigated the effect of LL-37 on bacterial phagocytosis by…
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