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Longevity

Hyperbaric OxygenEvidence & Dosage

Telomere, brain injury and anti-aging studies

Studies last updated

Evidence at a glance

Total studies
1,000
With abstract
50
Meta / Systematic / RCT
147
Highly cited
50
Publication years
1977–2026

Hyperbaric Oxygen in the context of Longevity

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Top studies on Hyperbaric Oxygen

Ranked by influential-citation count and publication year.

  1. A Systematic Review Informing the Management of Symptomatic Brain Radiation Necrosis After Stereotactic Radiosurgery and International Stereotactic Radiosurgery Society Recommendations.

    Int J Radiat Oncol Biol Phys2024n=21Systematic Review179 influential citations

    Radiation necrosis (RN) secondary to stereotactic radiosurgery is a significant cause of morbidity. The optimal management of corticosteroid-refractory brain RN remains unclear. Our objective was to summarize the literature specific to…

  2. Adverse effects of hyperbaric oxygen therapy: a systematic review and meta-analysis.

    Front Med (Lausanne)2023n=1,497Systematic Review103 influential citations

    Introduction Hyperbaric oxygen therapy (HBOT) is one of the common clinical treatments, but adverse effects have hampered and limited the clinical application and promotion of hyperbaric oxygen therapy. A systematic review and…

  3. The effect of hyperbaric oxygen therapy on the clinical outcomes of necrotizing soft tissue infections: a systematic review and meta-analysis.

    World J Emerg Surg2023n=49,152Meta-Analysis97 influential citations

    Background To determine the efficacy of hyperbaric oxygen therapy (HBO) in the treatment of necrotizing soft tissue infections (NSTI), we conducted a meta-analysis of the available evidence. Methods Data sources were PubMed, Embase, Web of…

  4. The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis.

    Biomolecules2021n=98Systematic Review91 influential citations

    Hyperbaric oxygen therapy (HBOT) is commonly used as treatment in several diseases, such as non-healing chronic wounds, late radiation injuries and carbon monoxide poisoning. Ongoing research into HBOT has shown that preconditioning for…

  5. Hyperbaric Oxygen Therapy for Patients With Sudden Sensorineural Hearing Loss: A Systematic Review and Meta-analysis.

    JAMA Otolaryngol Head Neck Surg2022n=150Meta-Analysis91 influential citations

    <h4>Importance</h4>Sudden sensorineural hearing loss (SSNHL) is an acute, usually unilateral deficit. Systemic and intratympanic steroids are accepted treatments. Although evidence suggests that hyperbaric oxygen therapy (HBOT) may be…

  6. Hyperbaric oxygen therapy for late radiation tissue injury.

    Cochrane Database Syst Rev2023n=107Systematic Review83 influential citations

    <h4>Background</h4>This is the third update of the original Cochrane Review published in July 2005 and updated previously in 2012 and 2016. Cancer is a significant global health issue. Radiotherapy is a treatment modality for many…

  7. Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials.

    Sci Rep2021Meta-Analysis70 influential citations

    Studies have suggested that hyperbaric oxygen therapy (HBOT) is effective in the healing of diabetic foot ulcer (DFU); however, there is a lack of consensus. Therefore, to assess the efficacy of HBOT on diabetic foot ulcer among diabetic…

  8. Impact of Hyperbaric Oxygen Therapy on Cognitive Functions: a Systematic Review.

    Neuropsychol Rev2022Systematic Review64 influential citations

    Hyperbaric oxygen therapy (HBOT) is a modality of treatment in which patients inhale 100% oxygen inside a hyperbaric chamber pressurised to greater than 1 atmosphere. The aim of this review is to discuss neuropsychological findings in…

  9. Cellular and Molecular Targets for Non-Invasive, Non-Pharmacological Therapeutic/Rehabilitative Interventions in Acute Ischemic Stroke.

    Int J Mol Sci2022n=54Systematic Review63 influential citations

    BACKGROUND: Cerebral circulation delivers the blood flow to the brain through a dedicated network of sanguine vessels. A healthy human brain can regulate cerebral blood flow (CBF) according to any physiological or pathological challenges.…

  10. Higher versus lower fractions of inspired oxygen or targets of arterial oxygenation for adults admitted to the intensive care unit.

    Cochrane Database Syst Rev2023n=19Meta-Analysis63 influential citations

    <h4>Background</h4>This is an updated review concerning 'Higher versus lower fractions of inspired oxygen or targets of arterial oxygenation for adults admitted to the intensive care unit'. Supplementary oxygen is provided to most patients…

    Finding: In adults admitted to the ICU, higher versus lower oxygenation strategies did not show a significant difference in all-cause mortality at maximum follow-up.

Frequently asked

What dosage was studied?
• Bevacizumab; laser interstitial thermal therapy (LITT); surgical resection; hyperbaric oxygen therapy (Bevacizumab low-dose defined as ≤7.5 mg/kg every 3 weeks in subgroup analysis) • Hyperbaric oxygen therapy (HBOT) (Pressures 1.5–2.5 ATA; course 7–60 sessions) • Hyperbaric oxygen therapy (HBO) (Not reported)
Are there safety considerations for Hyperbaric Oxygen?
• Toxicity was generally low for all treatment paradigms. • Ear discomfort was the most frequent adverse effect. • Ocular side effects were increased with HBOT. • Risk of adverse effects was higher at chamber pressure ≥2.0 ATA.

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