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SulforaphaneEvidence & Dosage

NRF2 pathway, broccoli sprouts, detox, and cancer prevention.

Studies last updated

Evidence at a glance

Total studies
1,000
With abstract
50
Meta / Systematic / RCT
85
Highly cited
50
Publication years
1992–2026

Sulforaphane in the context of Vitamins & Minerals

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Top studies on Sulforaphane

Ranked by influential-citation count and publication year.

  1. Sulforaphane treatment of autism spectrum disorder (ASD).

    Proc Natl Acad Sci U S A2014n=44RCT117 influential citations

    Autism spectrum disorder (ASD), characterized by both impaired communication and social interaction, and by stereotypic behavior, affects about 1 in 68, predominantly males. The medico-economic burdens of ASD are enormous, and no…

  2. Bioactive sulforaphane from cruciferous vegetables: advances in biosynthesis, metabolism, bioavailability, delivery, health benefits, and applications.

    Critical reviews in food science and nutrition2025D108 influential citations

    Chronic inflammation-induced diseases (CID) are the dominant cause of death worldwide, contributing to over half of all global deaths. Sulforaphane (SFN) derived from cruciferous vegetables has been extensively studied for its multiple…

  3. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans.

    Cancer Epidemiol Biomarkers Prev2001Clinical Trial86 influential citations

    Broccoli sprouts are a rich source of glucosinolates and isothiocyanates that induce phase 2 detoxication enzymes, boost antioxidant status, and protect animals against chemically induced cancer. Glucosinolates are hydrolyzed by myrosinase…

  4. Improving insulin resistance by sulforaphane via activating the Bacteroides and Lactobacillus SCFAs-GPR-GLP1 signal axis.

    Food Funct2024n=36RCT77 influential citations

    <i>Background</i>: Insulin resistance (IR) is closely associated with non-alcoholic fatty liver disease (NAFLD), and the gut microbiome contributes to the development of NAFLD. Sulforaphane (SFN) is a phytochemical in cruciferous…

  5. Sulforaphane upregulates the mRNA expression of NRF2 and NQO1 in non-dialysis patients with chronic kidney disease.

    Free Radic Biol Med2024RCT68 influential citations

    Sulforaphane (SFN), found in cruciferous vegetables, is a known activator of NRF2 (master regulator of cellular antioxidant responses). Patients with chronic kidney disease (CKD) present an imbalance in the redox state, presenting reduced…

  6. Effects of long-term consumption of broccoli sprouts on inflammatory markers in overweight subjects.

    Clin Nutr2019n=40Clinical Trial66 influential citations

    <h4>Background & aims</h4>Broccoli sprouts represent an interesting choice of healthy food product as they are rich in glucosinolates and their cognate bioactive metabolites, isothiocyanates able to counteract the negative effects of…

  7. Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study.

    Nutr Cancer2006n=12RCT65 influential citations

    Broccoli sprouts are widely consumed in many parts of the world. There have been no reported concerns with respect to their tolerance and safety in humans. A formal phase I study of safety, tolerance, and pharmacokinetics appeared…

  8. Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial.

    Nat Microbiol2025n=89rct65 influential citations

    More effective treatments are needed for impaired fasting glucose or glucose intolerance, known as prediabetes. Sulforaphane is an isothiocyanate that reduces hepatic gluconeogenesis in individuals with type 2 diabetes and is well…

  9. Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoli.

    Nutr Cancer2000n=12RCT64 influential citations

    The cancer-chemopreventive effects of broccoli may be attributed, in part, to isothiocyanates (ITCs), hydrolysis products of glucosinolates. Glucosinolates are hydrolyzed to their respective ITCs by the enzyme myrosinase, which is…

  10. A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer.

    Invest New Drugs2015n=20Clinical Trial63 influential citations

    <h4>Introduction</h4>Diets high in cruciferous vegetables are associated with lower risk of incidence of prostate cancer, including aggressive forms of this disease. Human intervention studies with cruciferous vegetable-rich diets also…

Frequently asked

What dosage was studied?
• Sulforaphane derived from broccoli sprout extracts (50-150 µmol daily oral doses) • Sulforaphane (SFN) and related formulations (not reported) • Broccoli sprout glucosinolates, isothiocyanates, and intact fresh sprouts with active myrosinase (111 micromol doses of isothiocyanates; repeated 50-micromol doses; escalating doses 25- to 200-micromol range)
Are there safety considerations for Sulforaphane?
• Sulforaphane is described as having recognized low toxicity. • No adverse events are reported in the abstract. • Further exploration is required regarding toxicity profiles and stability of SFN. • not reported

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