SemaxEvidence & Dosage

Top studies on Semax

Ranked by influential-citation count and publication year.

1. 01

   The GLP-1 agonist semaglutide ameliorates cognitive regression in P301S tauopathy mice model via autophagy/ACE2/SIRT1/FOXO1-Mediated Microglia Polarization.

   European journal of pharmacology·202546 influential citations

   Tau hyper-phosphorylation has been recognized as an essential contributor to neurodegeneration in Alzheimer's disease (AD) and related tauopathies. In the last decade, tau hyper-phosphorylation has gained considerable concern in AD…

2. 02

   Semaglutide-mediated protection against Aβ correlated with enhancement of autophagy and inhibition of apotosis.

   Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·202029 influential citations

   <h4>Background</h4>Semaglutide, a glucagon-like peptide-1 (GLP-1) analogue with an extended half-life of approximately 1 week has being come into clinic trial to treat parkingson's disease but little is known about its effect to prevent…

3. 03

   Semax, an analog of ACTH(4−7), regulates expression of immune response genes during ischemic brain injury in rats

   Molecular Genetics and Genomics·20179 influential citations

   Brain stroke continues to claim the lives of million people every year. To build the effective strategies for stroke treatment it is necessary to understand the neuroprotective mechanisms that are able to prevent the ischemic injury.…

4. 04

   The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis

   BMC Genomics·20148 influential citations

   <h4>Background</h4>The nootropic neuroprotective peptide Semax (Met-Glu-His-Phe-Pro-Gly-Pro) has proved efficient in the therapy of brain stroke; however, the molecular mechanisms underlying its action remain obscure. Our genome-wide study…

5. 05

   Antidepressant-like and antistress effects of the ACTH(4–10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress

   European Journal of Pharmacology·20248 influential citations

   Current antidepressant therapy shows substantial limitations, and there is an urgent need for the development of new treatment strategies for depression. Stressful events and hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis…

6. 06

   The efficacy of semax in the tretament of patients at different stages of ischemic stroke

   Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova·2018·n=677 influential citations

   <h4>Aim</h4>To evaluate the efficacy of semax and timing of rehabilitation on the dynamics of plasma BDNF levels, motor performance, and Barthel index score in patients after ischemic stroke (IS).<h4>Material and methods</h4>One hundred…

7. 07

   Degradation of ACTH/MSH(4–10) and its synthetic analog semax by rat serum enzymes: An inhibitor study

   Peptides·19936 influential citations

   Degradation of the behaviorally active peptide ACTH/MSH(4-10) and its synthetic analog semax was studied in serum in the presence of several specific peptidase inhibitors. Bestatin and puromycin were used to inhibit aminopeptidase…

8. 08

   Experimental Substantiation of Application of Semax as a Modulator of Immune Reaction on the Model of “Social” Stress

   Bulletin of Experimental Biology and Medicine·20196 influential citations

   We studied immunocorrecting effects of Semax (Met-Glu-His-Phe-Pro-Gly-Pro) on the model of "social" stress caused by sensory contact and intermale confrontation. Functional activity of the immune system of laboratory animals was evaluated…

9. 09

   Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity

   Journal of Inorganic Biochemistry·20155 influential citations

   Heptapeptide Semax, encompassing the sequence 4-7 of N-terminal domain of the adrenocorticotropic hormone (ACTH) and a C-terminal Pro-Gly-Pro tripeptide, belongs to a short regulatory peptides family. This compound has been found to affect…

10. 10

    Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties

    Journal of Inorganic Biochemistry·20163 influential citations

    Semax is a heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) that encompasses the sequence 4-7 of N-terminal domain of the adrenocorticotropic hormone and a C-terminal Pro-Gly-Pro tripeptide. N-terminal amino group acetylation (Ac-Semax)…