Restless LegsEvidence & Dosage
Iron, the dopamine hypothesis, lifestyle factors.
Evidence at a glance
- Total studies
- 1,000
- With abstract
- 50
- Meta / Systematic / RCT
- 152
- Highly cited
- 50
- Publication years
- 1989–2026
Restless Legs in the context of Sleep
This topic is part of our "Sleep" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to SleepTop studies on Restless Legs
Ranked by influential-citation count and publication year.
Sleep disturbances during pregnancy and adverse maternal and fetal outcomes: A systematic review and meta-analysis.
Sleep Med Rev2021n=58,123,250meta200 influential citationsSleep disturbances are highly prevalent in pregnancy and are frequently overlooked as a potential cause of significant morbidity. The association between sleep disturbances and pregnancy outcomes remains largely controversial and needs to…
Worldwide estimation of restless legs syndrome: a systematic review and meta-analysis of prevalence in the general adult population.
J Sleep Res2023Meta-Analysis148 influential citationsSummary This systematic review, meta‐analysis and meta‐regression assessed the prevalence of restless legs syndrome (RLS) in the general adult population. Studies identified in Scopus, PubMed, Web of Science, and PsycInfo between January…
Restless legs syndrome associated with major diseases: A systematic review and new concept.
Neurology2016Systematic Review139 influential citationsRecent publications on both the genetics and environmental factors of restless legs syndrome (RLS) defined as a clinical disorder suggest that overlapping genetic risk factors may play a role in primary (idiopathic) and secondary…
Sleep disturbances and sleep disorders in adults living with chronic pain: a meta-analysis.
Sleep Med2018n=37Meta-Analysis129 influential citations<h4>Objectives</h4>Chronic pain, with or without an identified diagnosis or cause, is widespread and commonly associated with sleep disturbances. However, research has often used poor quality measures of sleep and focused on specific pain…
Sleep disorders and non-sleep circadian disorders predict depression: A systematic review and meta-analysis of longitudinal studies.
Neurosci Biobehav Rev2022Meta-Analysis123 influential citationsPatients with depression often suffer from sleep disorders and non-sleep circadian disorders. However, whether they precede and predict subsequent depression is unclear. We conducted a meta-analysis of studies on sleep disorders and…
Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction.
Nat Genet2024n=116,647Meta-Analysis123 influential citationsRestless legs syndrome (RLS) affects up to 10% of older adults. Their healthcare is impeded by delayed diagnosis and insufficient treatment. To advance disease prediction and find new entry points for therapy, we performed meta-analyses of…
A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015.
Sleep Med Rev2017Systematic Review122 influential citationsSleep disorders are among the most common non-motor manifestations in Parkinson's disease (PD) and have a significant negative impact on quality of life. While sleep disorders in PD share most characteristics with those that occur in the…
Sleep Disorders in Cancer-A Systematic Review.
Int J Environ Res Public Health2021n=89systematic100 influential citationsINTRODUCTION: Sleep disorders, especially insomnia, are very common in different kinds of cancers, but their prevalence and incidence are not well-known. Disturbed sleep in cancer is caused by different reasons and usually appears as a…
Sleep disorders increase the risk of dementia, Alzheimer's disease, and cognitive decline: a meta-analysis.
Geroscience2025n=39Meta-Analysis93 influential citationsSleep disorders, particularly insomnia and obstructive sleep apnea, are increasingly implicated as significant contributors to cognitive decline, dementia, and neurodegenerative diseases such as Alzheimer's disease (AD) and vascular…
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes.
Nat Commun2019n=452,071Meta-Analysis89 influential citationsExcessive daytime sleepiness (EDS) affects 10–20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from the UK Biobank,…
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