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Restless LegsStudienlage & Dosis

Eisen, Dopamin-Hypothese, Lifestyle-Faktoren.

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Studienlage in Zahlen

Studien gesamt
1.000
Mit Abstract
50
Meta / Systematic / RCT
152
Häufig zitiert
50
Erscheinungsjahre
1989–2026

Restless Legs im Kontext von Schlaf

Dieses Thema ist Teil unserer Welt „Schlaf". Dort findest du Methodik, Studienlage und Hebel mit dem größten Effekt — sowie die Reihenfolge, in der sich Hebel sinnvoll aufeinander aufbauen.

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Top-Studien zu Restless Legs

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

  1. Sleep disturbances during pregnancy and adverse maternal and fetal outcomes: A systematic review and meta-analysis.

    Sleep Med Rev2021n=58.123.250meta200 einflussreiche Zitationen

    Sleep disturbances are highly prevalent in pregnancy and are frequently overlooked as a potential cause of significant morbidity. The association between sleep disturbances and pregnancy outcomes remains largely controversial and needs to…

  2. Worldwide estimation of restless legs syndrome: a systematic review and meta-analysis of prevalence in the general adult population.

    J Sleep Res2023Meta-Analysis148 einflussreiche Zitationen

    Summary This systematic review, meta‐analysis and meta‐regression assessed the prevalence of restless legs syndrome (RLS) in the general adult population. Studies identified in Scopus, PubMed, Web of Science, and PsycInfo between January…

  3. Restless legs syndrome associated with major diseases: A systematic review and new concept.

    Neurology2016Systematic Review139 einflussreiche Zitationen

    Recent publications on both the genetics and environmental factors of restless legs syndrome (RLS) defined as a clinical disorder suggest that overlapping genetic risk factors may play a role in primary (idiopathic) and secondary…

  4. Sleep disturbances and sleep disorders in adults living with chronic pain: a meta-analysis.

    Sleep Med2018n=37Meta-Analysis129 einflussreiche Zitationen

    <h4>Objectives</h4>Chronic pain, with or without an identified diagnosis or cause, is widespread and commonly associated with sleep disturbances. However, research has often used poor quality measures of sleep and focused on specific pain…

  5. Sleep disorders and non-sleep circadian disorders predict depression: A systematic review and meta-analysis of longitudinal studies.

    Neurosci Biobehav Rev2022Meta-Analysis123 einflussreiche Zitationen

    Patients with depression often suffer from sleep disorders and non-sleep circadian disorders. However, whether they precede and predict subsequent depression is unclear. We conducted a meta-analysis of studies on sleep disorders and…

  6. Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction.

    Nat Genet2024n=116.647Meta-Analysis123 einflussreiche Zitationen

    Restless legs syndrome (RLS) affects up to 10% of older adults. Their healthcare is impeded by delayed diagnosis and insufficient treatment. To advance disease prediction and find new entry points for therapy, we performed meta-analyses of…

  7. A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015.

    Sleep Med Rev2017Systematic Review122 einflussreiche Zitationen

    Sleep disorders are among the most common non-motor manifestations in Parkinson's disease (PD) and have a significant negative impact on quality of life. While sleep disorders in PD share most characteristics with those that occur in the…

  8. Sleep Disorders in Cancer-A Systematic Review.

    Int J Environ Res Public Health2021n=89systematic100 einflussreiche Zitationen

    INTRODUCTION: Sleep disorders, especially insomnia, are very common in different kinds of cancers, but their prevalence and incidence are not well-known. Disturbed sleep in cancer is caused by different reasons and usually appears as a…

  9. Sleep disorders increase the risk of dementia, Alzheimer's disease, and cognitive decline: a meta-analysis.

    Geroscience2025n=39Meta-Analysis93 einflussreiche Zitationen

    Sleep disorders, particularly insomnia and obstructive sleep apnea, are increasingly implicated as significant contributors to cognitive decline, dementia, and neurodegenerative diseases such as Alzheimer's disease (AD) and vascular…

  10. Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes.

    Nat Commun2019n=452.071Meta-Analysis89 einflussreiche Zitationen

    Excessive daytime sleepiness (EDS) affects 10–20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from the UK Biobank,…

Häufige Fragen

Gibt es Sicherheitshinweise zu Restless Legs?
• Pharmacologic sleep treatments may cause headaches, dizziness, fatigue, daytime sleepiness, and residual sedation. • Cancer patients may be especially susceptible to sedative adverse effects. • The review highlights need for careful treatment selection in comorbid cancer and sleep disorders.

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Alkohol & Schlaf

Schnelleres Einschlafen, aber REM-Suppression und Wach-Phasen.

Antihistaminika

Diphenhydramin, Doxylamin — Schlaf-Frags, anticholinerge Demenz-Risiken.

Apigenin

Kamille, GABA-Modulation und Schlafqualität.

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Flavonoid aus Kamille, GABA-Modulation, Schlafqualität.

Ashwagandha (Schlaf)

Cortisol-Senkung, Schlafqualität — KSM-66 und Sensoril-Extrakte.

Dunkelheit

Blackout-Vorhänge, Schlafmaske — Melatonin und Schlaftiefe.

Raumtemperatur

Optimal 17-19°C — Körperkerntemperatur-Abfall fördert Schlaf.

Benzodiazepine

Sedativum/Hypnotikum — Abhängigkeit, kognitive Risiken im Alter.

Blaulichtfilter

f.lux, Night Shift, Brillen — Evidenz und Marketing-Hype.

Bruxismus

Zähneknirschen — Stress, Schiene, Trigger-Faktoren.

Koffein-Timing

Halbwertszeit ~5-6h — Cut-off 8-10h vor Schlaf.

CBD for Sleep

Endocannabinoid-System, REM-Effekte und Dosierungs-Spektrum.

CBT-I

Kognitive Verhaltenstherapie für Insomnie — Erstlinien-Therapie laut Leitlinie.

Circadianer Rhythmus

Innere ~24h-Uhr — Licht als Hauptsignal, periphere Uhren in Organen.

CPAP

Continuous Positive Airway Pressure — Standard bei mittelschwerer Apnoe.

Tiefschlaf

N3-Slow-Wave-Sleep — körperliche Regeneration, GH-Ausschüttung.

GABA Supplements

Blut-Hirn-Schranke, fermentiertes GABA und Wirksamkeits-Daten.

Glycine for Sleep

Tiefschlaf, Körpertemperatur-Senkung und 3g abends.

Glycin (Schlaf)

3g vor dem Schlaf — Körperkerntemperatur-Senkung, Tiefschlaf-Modulation.

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