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Glycine for SleepStudienlage & Dosis

Tiefschlaf, Körpertemperatur-Senkung und 3g abends.

Studien zuletzt aktualisiert

Studienlage in Zahlen

Studien gesamt
328
Mit Abstract
49
Meta / Systematic / RCT
50
Häufig zitiert
50
Erscheinungsjahre
1987–2026

Glycine for Sleep im Kontext von Schlaf

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Top-Studien zu Glycine for Sleep

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

  1. Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review.

    Oxid Med Cell Longev2017Review87 einflussreiche Zitationen

    Glycine is most important and simple, nonessential amino acid in humans, animals, and many mammals. Generally, glycine is synthesized from choline, serine, hydroxyproline, and threonine through interorgan metabolism in which kidneys and…

  2. D-serine efficacy as add-on pharmacotherapy to risperidone and olanzapine for treatment-refractory schizophrenia.

    Biol Psychiatry2005n=39RCT79 einflussreiche Zitationen

    <h4>Background</h4>D-serine, a selective full agonist at the glycine site of N-methyl-D-aspartate glutamate receptor, might presently be the compound of choice for counteracting the hypothesized dysfunction of this receptor class in…

  3. Effect of bitopertin, a glycine reuptake inhibitor, on negative symptoms of schizophrenia: a randomized, double-blind, proof-of-concept study.

    JAMA Psychiatry2014n=323RCT75 einflussreiche Zitationen

    <h4>Importance</h4>In schizophrenia, the severity of negative symptoms is a key predictor of long-term disability. Deficient signaling through the N-methyl-D-aspartate receptor is hypothesized to underlie many signs and symptoms associated…

  4. Strategies to enhance N-methyl-D-aspartate receptor-mediated neurotransmission in schizophrenia, a critical review and meta-analysis.

    Curr Pharm Des2010Meta-Analysis65 einflussreiche Zitationen

    Although hypofunction of N-methyl-D-aspartate (NMDA) receptor-mediated neurotransmission is proposed to play an important role in the pathophysiology of schizophrenia, results of the clinical trials of small molecules that enhance the NMDA…

  5. The neuronal network responsible for paradoxical sleep and its dysfunctions causing narcolepsy and rapid eye movement (REM) behavior disorder.

    Sleep medicine reviews2011D64 einflussreiche Zitationen

    Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by the loss of muscle atonia during paradoxical (REM) sleep (PS). Conversely, cataplexy, one of the key symptoms of narcolepsy, is a striking sudden…

  6. GABA and glycine as neurotransmitters: a brief history.

    British journal of pharmacology2006E56 einflussreiche Zitationen

    gamma-Aminobutyric acid (GABA) emerged as a potentially important brain chemical just over 50 years ago, but its significance as a neurotransmitter was not fully realized until over 16 years later. We now know that at least 40% of…

  7. Elevations of endogenous kynurenic acid produce spatial working memory deficits.

    Schizophrenia bulletin2007E55 einflussreiche Zitationen

    Kynurenic acid (KYNA) is a tryptophan metabolite that is synthesized and released by astrocytes and acts as a competitive antagonist of the glycine site of N-methyl-D-aspartate receptors at high concentrations and as a noncompetitive…

  8. REM Sleep at its Core - Circuits, Neurotransmitters, and Pathophysiology.

    Frontiers in neurology2015D52 einflussreiche Zitationen

    Rapid eye movement (REM) sleep is generated and maintained by the interaction of a variety of neurotransmitter systems in the brainstem, forebrain, and hypothalamus. Within these circuits lies a core region that is active during REM sleep,…

  9. A randomized add-on trial of high-dose D-cycloserine for treatment-resistant depression.

    Int J Neuropsychopharmacol2013n=26RCT50 einflussreiche Zitationen

    Antagonism of N-methyl-D-aspartate glutamatergic receptors (NMDAR) may represent an effective antidepressant mechanism. D-cycloserine (DCS) is a partial agonist at the NMDAR-associated glycine modulatory site that at high doses acts as a…

  10. Glycine antagonist in neuroprotection for patients with acute stroke: GAIN Americas: a randomized controlled trial.

    JAMA2001n=136RCT49 einflussreiche Zitationen

    <h4>Context</h4>Elucidation of the ischemic cascade has helped stimulate development of neuroprotective drugs aimed at limiting brain injury in the hours following an ischemic stroke. To date, none of these drugs has shown clinical…

Häufige Fragen

Welche Dosierung wurde in den Studien untersucht?
• Oral, intravenous, dietary, and experimental glycine supplementation (Varies across cited studies; examples include 2 g/day orally, 3 mM, 25 mg/kg, 50-300 mg/kg, 250 ml of 300 mM) • D-serine add-on to risperidone or olanzapine (30 mg/kg/day) • Bitopertin (RG1678), a glycine reuptake inhibitor, added to standard antipsychotic therapy (10 mg/d, 30 mg/d, or 60 mg/d)
Gibt es Sicherheitshinweise zu Glycine for Sleep?
• Large amounts of glycine are toxic to the human body. • Oral glycine is quickly metabolized in the digestive system. • Human liver transplant protocols used 250 ml of 300 mM glycine pre-implantation and 25 ml daily post-op. • The review notes the need for precautions for safe intake and dose.

Weitere Themen in Schlaf

Glycin

Glycin, Schlafqualität, Körpertemperatur und Sicherheit.

Alkohol & Schlaf

Schnelleres Einschlafen, aber REM-Suppression und Wach-Phasen.

Antihistaminika

Diphenhydramin, Doxylamin — Schlaf-Frags, anticholinerge Demenz-Risiken.

Apigenin

Kamille, GABA-Modulation und Schlafqualität.

Apigenin (Schlaf)

Flavonoid aus Kamille, GABA-Modulation, Schlafqualität.

Ashwagandha (Schlaf)

Cortisol-Senkung, Schlafqualität — KSM-66 und Sensoril-Extrakte.

Dunkelheit

Blackout-Vorhänge, Schlafmaske — Melatonin und Schlaftiefe.

Raumtemperatur

Optimal 17-19°C — Körperkerntemperatur-Abfall fördert Schlaf.

Benzodiazepine

Sedativum/Hypnotikum — Abhängigkeit, kognitive Risiken im Alter.

Blaulichtfilter

f.lux, Night Shift, Brillen — Evidenz und Marketing-Hype.

Bruxismus

Zähneknirschen — Stress, Schiene, Trigger-Faktoren.

Koffein-Timing

Halbwertszeit ~5-6h — Cut-off 8-10h vor Schlaf.

CBD for Sleep

Endocannabinoid-System, REM-Effekte und Dosierungs-Spektrum.

CBT-I

Kognitive Verhaltenstherapie für Insomnie — Erstlinien-Therapie laut Leitlinie.

Circadianer Rhythmus

Innere ~24h-Uhr — Licht als Hauptsignal, periphere Uhren in Organen.

CPAP

Continuous Positive Airway Pressure — Standard bei mittelschwerer Apnoe.

Tiefschlaf

N3-Slow-Wave-Sleep — körperliche Regeneration, GH-Ausschüttung.

GABA Supplements

Blut-Hirn-Schranke, fermentiertes GABA und Wirksamkeits-Daten.

Glycin (Schlaf)

3g vor dem Schlaf — Körperkerntemperatur-Senkung, Tiefschlaf-Modulation.

Glymphatisches System

Gehirn-Detox während Schlaf — Beta-Amyloid-Clearance.

Verwandte Themen aus anderen Welten

Kognition

Binaurale Beats

Auditive Frequenz-Stimulation — Wirknachweise gemischt.

Kognition

Dopamin

Motivation, Belohnung, Bewegung, Lernen — zentrale Reward-Chemie.

Kognition

L-Theanin

Alpha-Wellen, Entspannung ohne Sedierung, Koffein-Synergie.

Kognition

Neurofeedback

EEG-basierte Selbstregulation — ADHS, Angst, Performance.

Kognition

Phosphatidylserine

Cortisol-Senkung, Gedächtnis und Demenz-Studien.

Kognition

Spaced Repetition

Anki, Leitner-System — evidenzstärkste Lerntechnik.