GABA SupplementsStudienlage & Dosis

Top-Studien zu GABA Supplements

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

1. 01

   Pregabalin for neuropathic pain in adults.

   Cochrane Database Syst Rev·2019·n=11.906Meta-Analysis177 einflussreiche Zitationen

   <h4>Background</h4>This review updates part of an earlier Cochrane Review titled "Pregabalin for acute and chronic pain in adults", and considers only neuropathic pain (pain from damage to nervous tissue). Antiepileptic drugs have long…

   Befund: In postherpetic neuralgia, pregabalin 300 mg increased the proportion of participants achieving at least 30% pain intensity reduction compared with placebo.

2. 02

   Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review.

   Front Neurosci·2020·n=14Systematic Review117 einflussreiche Zitationen

   Gamma-aminobutyric acid (GABA) is a non-proteinogenic amino acid and is the main inhibitory neurotransmitter in the mammalian brain. GABA's stress-reducing, and sleep enhancing effects have been established. However, although several human…

3. 03

   GABAergic dysfunction in mood disorders.

   Molecular psychiatry·2003111 einflussreiche Zitationen

   The authors review the available literature on the preclinical and clinical studies involving GABAergic neurotransmission in mood disorders. Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter present almost exclusively in the…

4. 04

   Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments.

   Molecular psychiatry·2002111 einflussreiche Zitationen

   Glutamate and gamma-amino butyric acid (GABA) systems are emerging as targets for development of medications for mood disorders. There is increasing preclinical and clinical evidence that antidepressant drugs directly or indirectly reduce…

5. 05

   Brain GABA levels across psychiatric disorders: A systematic literature review and meta-analysis of (1) H-MRS studies.

   Hum Brain Mapp·2016·n=1.591Meta-Analysis109 einflussreiche Zitationen

   The inhibitory gamma‐aminobutyric acid (GABA) system is involved in the etiology of most psychiatric disorders, including schizophrenia, autism spectrum disorder (ASD) and major depressive disorder (MDD). It is therefore not surprising…

6. 06

   The role of glutamate and GABA in cognitive dysfunction in schizophrenia and mood disorders - A systematic review of magnetic resonance spectroscopy studies.

   Schizophr Res·2022·n=37Systematic Review94 einflussreiche Zitationen

   Epidemiologic, genetic, and neurobiological studies suggest considerable overlap between schizophrenia and mood disorders. Importantly, both disorders are associated with a broad range of cognitive deficits as well as altered glutamatergic…

7. 07

   The analgesic effects of perioperative gabapentin on postoperative pain: a meta-analysis.

   Reg Anesth Pain Med·2006·n=896Meta-Analysis74 einflussreiche Zitationen

   <h4>Background and objectives</h4>Gabapentin is an anticonvulsant that has been shown to be effective in the treatment of neuropathic and inflammatory pain in animal and human studies. The analgesic effect of its perioperative use has not…

8. 08

   Pharmacological and neurosurgical interventions for individuals with cerebral palsy and dystonia: a systematic review update and meta-analysis.

   Dev Med Child Neurol·2021·n=915Meta-Analysis71 einflussreiche Zitationen

   Aim To update a systematic review of evidence published up to December 2015 for pharmacological/neurosurgical interventions among individuals with cerebral palsy (CP) and dystonia. Method Searches were updated (January 2016 to May 2020)…

   Befund: Intrathecal baclofen and deep brain stimulation may improve quality of life in individuals with cerebral palsy and dystonia.

9. 09

   Efficacy of non-invasive brain stimulation combined with antidepressant medications for depression: a systematic review and meta-analysis of randomized controlled trials.

   Syst Rev·2024·n=135Meta-Analysis67 einflussreiche Zitationen

   <h4>Background</h4>Antidepressants, noninvasive brain stimulation (NIBS), and their combination are commonly used in routine clinical practice. Nevertheless, there is a continuous dispute regarding whether the effectiveness of NIBS in…

   Befund: In this meta-analysis of 18 randomized controlled trials, combination treatment with non-invasive brain stimulation and antidepressants was significantly more effective than antidepressant monotherapy for improving depressive symptoms.

10. 10

    A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems.

    Drug Discov Today·2019Systematic Review66 einflussreiche Zitationen

    Mood disorders represent the largest cause of disability worldwide. The monoaminergic deficiency hypothesis, which has dominated the conceptual framework for researching the pathophysiology of mood disorders and the development of novel…

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