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Diagnostik & Biomarker

Geroscience BiomarkersStudienlage & Dosis

Automatisch via Trend Scout entdeckt. Aging biomarkers and biological clocks are central to longevity interventions and geroscience research.. PubMed: 479 Ergebnisse.

Studien zuletzt aktualisiert

Studienlage in Zahlen

Studien gesamt
316
Mit Abstract
49
Meta / Systematic / RCT
7
Häufig zitiert
21
Erscheinungsjahre
2009–2026

Geroscience Biomarkers im Kontext von Diagnostik & Biomarker

Dieses Thema ist Teil unserer Welt „Diagnostik & Biomarker". Dort findest du Methodik, Studienlage und Hebel mit dem größten Effekt — sowie die Reihenfolge, in der sich Hebel sinnvoll aufeinander aufbauen.

Zur Welt Diagnostik & Biomarker

Top-Studien zu Geroscience Biomarkers

Sortiert nach einflussreichen Zitationen (Semantic Scholar) und Erscheinungsjahr.

  1. A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer's disease.

    EBioMedicine2025n=12Study168 einflussreiche Zitationen

    <h4>Background</h4>This single-arm study evaluates the feasibility, safety, and preliminary effects of two senolytic agents, Dasatinib and Quercetin (DQ), in older adults at risk of Alzheimer's disease.<h4>Methods</h4>Participants took 100…

  2. A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup.

    Geroscience2018Review98 einflussreiche Zitationen

    Recent advances indicate that biological aging is a potentially modifiable driver of late-life function and chronic disease and have led to the development of geroscience-guided therapeutic trials such as TAME (Targeting Aging with…

  3. Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases.

    Trends Biochem Sci2020Review68 einflussreiche Zitationen

    Aging is a major risk factor for numerous human pathologies, including cardiovascular, metabolic, musculoskeletal, and neurodegenerative conditions and various malignancies. While our understanding of aging is far from complete, recent…

  4. Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis.

    J Gerontol A Biol Sci Med Sci2017n=220RCT58 einflussreiche Zitationen

    Biological aging measures have been proposed as proxies for extension of healthy life span in trials of geroprotective therapies that aim to slow aging. Several methods to measure biological aging show promise but it is not known if these…

  5. The emerging role of miRNAs in biological aging and age-related diseases.

    Noncoding RNA Res2025Review55 einflussreiche Zitationen

    Ageing is a complex biological process characterised by the accumulation of molecular and cellular damage leading to functional decline and an increased risk of chronic disease and geriatric syndromes. Despite data showing that lifestyle…

  6. The Business of Anti-Aging Science.

    Trends Biotechnol2017Review35 einflussreiche Zitationen

    Age-related conditions are the leading causes of death and health-care costs. Reducing the rate of aging would have enormous medical and financial benefits. Myriad genes and pathways are known to regulate aging in model organisms,…

  7. Drugs Targeting Mechanisms of Aging to Delay Age-Related Disease and Promote Healthspan: Proceedings of a National Institute on Aging Workshop.

    J Gerontol A Biol Sci Med Sci2023Study32 einflussreiche Zitationen

    The geroscience hypothesis posits that by targeting key hallmarks of aging we may simultaneously prevent or delay several age-related diseases and thereby increase healthspan, or life span spent free of significant disease and disability.…

  8. Endpoints for geroscience clinical trials: health outcomes, biomarkers, and biologic age.

    Geroscience2022Study27 einflussreiche Zitationen

    Treatments that target fundamental processes of aging are expected to delay several aging-related conditions simultaneously. Testing the efficacy of these treatments for potential anti-aging benefits will require clinical trials with…

  9. Sex differences in epigenetic ageing for older people living with HIV.

    EBioMedicine2025Study23 einflussreiche Zitationen

    <h4>Background</h4>HIV-1 infection impacts biological ageing, and epigenetic clocks highlight epigenetic age acceleration in people with HIV. Despite evidence indicating sex differences in clinical, immunological, and virological measures,…

  10. The epitranscriptome in ageing and stress resistance: A systematic review.

    Ageing Res Rev2022Systematic Review17 einflussreiche Zitationen

    Modifications of RNA, collectively called the "epitranscriptome", might provide novel biomarkers and innovative targets for interventions in geroscience but are just beginning to be studied in the context of ageing and stress resistance.…

Häufige Fragen

Welche Dosierung wurde in den Studien untersucht?
• Dasatinib and Quercetin (senolytics) (100 mg Dasatinib and 1250 mg Quercetin)
Gibt es Sicherheitshinweise zu Geroscience Biomarkers?
• No serious adverse events were related to the intervention. • Not reported in the abstract. • Not reported; review article with no intervention safety data. • No adverse events reported; conceptual article only.

Weitere Themen in Diagnostik & Biomarker

Blutzucker

Nüchtern, postprandial, Glukoseschwankungen — Grundlage für metabolische Gesundheit.

Blutdruck-Tracking

Häusliche Messung, 24h-Messung, Weißkittelhypertonie.

Körpertemperatur-Tracking

Basaltemperatur, Zyklus, Krankheit, Schlafphasen via Wearable.

Blutbild

Kleines/großes Blutbild, Erythrozyten, Leukozyten, Thrombozyten — Standardpanel.

CGM

Echtzeit-Blutzucker via Sensor — Lernkurve und Limitationen.

Zyklus-Tracking

Menstruationszyklus, Symptome, Fertilität — Apps und Wearables.

Insulin & HOMA-IR

Insulinresistenz früh erkennen — wichtiger als HbA1c bei Risiko-Patienten.

HbA1c

3-Monats-Mittel des Blutzuckers, diabetisches Risiko, Longevity-Marker.

Homocystein

Methylierungs-Marker, kardiovaskuläres und neurologisches Risiko.

HRV-Tracking

Herzratenvariabilität als Resilienz- und Erholungs-Indikator.

Entzündungsmarker

hs-CRP, IL-6, Fibrinogen — chronische niedriggradige Entzündung als Risikofaktor.

Nierenwerte

Kreatinin, Harnstoff, eGFR, Cystatin C — Nierenfunktion bewerten.

Lipidprofil

LDL-C, HDL, Triglyceride, ApoB — moderne kardiovaskuläre Risiko-Bewertung.

Leberwerte

ALT, AST, GGT, Bilirubin — was hohe Werte bedeuten und wann sie ein Problem sind.

Stimmungstracking

Daily Mood Logging, Korrelationen mit Schlaf/Bewegung/Ernährung.

Ernährungstracking

Cronometer, MyFitnessPal, Makros & Mikros, Limitationen.

Ruhepuls

Trend-Marker für kardiovaskuläre Fitness und Übertraining.

Schilddrüsenwerte

TSH, fT3, fT4, ggf. reverse T3 und Antikörper — vollständiges Schilddrüsen-Panel.

VO2max

Maximale Sauerstoffaufnahme — stärkster Longevity-Prädiktor.

Wearables

Übersicht: Oura, Whoop, Apple Watch, Garmin, Fitbit — Vor- und Nachteile.

Verwandte Themen aus anderen Welten

Methoden

Pestizide

Bio vs. konventionell, Dirty Dozen, Glyphosat-Debatte.

Methoden

Sauna / Heat Therapy

Hitzeschock-Proteine, kardiovaskuläre Effekte und Finnish-Sauna-Kohorten.

Methoden

Sonnenlicht

UV, Vitamin D, NO-Freisetzung, Stimmungs-Effekte, Hautkrebs-Balance.

Longevity

ApoB

Bessere kardiovaskuläre Risiko-Metrik als LDL-C — moderne Lipidologie.

Longevity

Kollagen

Haut, Gelenke, Sehnen — Evidenz pro Hydrolysat plus Vitamin C.

Longevity

Glucosamine

Gelenke, UK Biobank Mortalitäts-Studie, Sulfat vs HCl-Formen.