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Longevity

PolyphenolsEvidence & Dosage

Plant compounds — hormesis, mitochondrial protection, the microbiome.

Evidence at a glance

Total studies
1,000
With abstract
50
Meta / Systematic / RCT
9
Highly cited
36
Publication years
1998–2026

Polyphenols in the context of Longevity

This topic is part of our "Longevity" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Polyphenols

Ranked by influential-citation count and publication year.

  1. Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions.

    Crit Rev Food Sci Nutr2003Review200 influential citations

    Increasing interest in the health benefits of tea has led to the inclusion of tea extracts in dietary supplements and functional foods. However, epidemiologic evidence regarding the effects of tea consumption on cancer and cardiovascular…

  2. Interactions of polyphenols with carbohydrates, lipids and proteins.

    Food chemistry2015200 influential citations

    Polyphenols are secondary metabolites in plants, investigated intensively because of their potential positive effects on human health. Their bioavailability and mechanism of positive effects have been studied, in vitro and in vivo. Lately,…

  3. The safety of green tea and green tea extract consumption in adults - Results of a systematic review.

    Regul Toxicol Pharmacol2018n=159Systematic Review150 influential citations

    A systematic review of published toxicology and human intervention studies was performed to characterize potential hazards associated with consumption of green tea and its preparations. A review of toxicological evidence from laboratory…

  4. Anti-inflammatory Action of Green Tea.

    Antiinflamm Antiallergy Agents Med Chem2016Review107 influential citations

    **BACKGROUND**: Green tea has been shown to have beneficial effects against a variety of diseases such as cancer, obesity, diabetes, cardiovascular disease, and neurodegenerative diseases. Through cellular, animal, and human experiments,…

  5. Tea and its consumption: benefits and risks.

    Crit Rev Food Sci Nutr2015Review106 influential citations

    The recent convention of introducing phytochemicals to support the immune system or combat diseases is a centuries' old tradition. Nutritional support is an emerging advancement in the domain of diet-based therapies; tea and its…

  6. Antioxidant activities of pomegranate fruit extract and its anthocyanidins: delphinidin, cyanidin, and pelargonidin.

    Journal of agricultural and food chemistry200286 influential citations

    Antioxidant activities of freeze-dried preparations of a 70% acetone extract of pomegranate (Punica granatum L.) and its three major anthocyanidins (delphinidin, cyanidin, and pelargonidin) were evaluated. Free radical scavenging…

  7. Antioxidant effects of tea: evidence from human clinical trials.

    J Nutr2003Review76 influential citations

    Tea remains the most consumed drink in the world after water, well ahead of coffee, beer, wine and carbonated soft drinks. An accumulated number of population studies suggests that consumption of green and black tea beverages may bring…

  8. Effects of green tea polyphenol extract and epigallocatechin-3-O-gallate on diabetes mellitus and diabetic complications: Recent advances.

    Crit Rev Food Sci Nutr2024Review71 influential citations

    Diabetes mellitus is one of the major non-communicable diseases accounting for millions of death annually and increasing economic burden. Hyperglycemic condition in diabetes creates oxidative stress that plays a pivotal role in developing…

  9. Green tea (Camellia sinensis) for the prevention of cancer.

    Cochrane Database Syst Rev2020n=142Meta-Analysis69 influential citations

    BACKGROUND: This review is an update of a previously published review in the Cochrane Database of Systematic Reviews (2009, Issue 3).Tea is one of the most commonly consumed beverages worldwide. Teas from the plant Camellia sinensis can be…

    Finding: High intake of green tea in nonexperimental studies was associated with lower overall cancer incidence, but not with cancer-related mortality.

  10. The effects of green tea extract supplementation on body composition, obesity-related hormones and oxidative stress markers: a grade-assessed systematic review and dose-response meta-analysis of randomised controlled trials.

    Br J Nutr2024n=380Meta-Analysis69 influential citations

    Research indicates that green tea extract (GTE) supplementation is beneficial for a range of conditions, including several forms of cancer, CVD and liver diseases; nevertheless, the existing evidence addressing its effects on body…

    Finding: In this meta-analysis of randomized controlled trials, green tea extract supplementation significantly reduced body mass, body fat percentage, BMI, and malondialdehyde.

Frequently asked

What dosage was studied?
• Tea consumption and green tea catechins/polyphenols (not reported) • Green tea and green tea extract consumption; concentrated catechin-rich green tea preparations, brewed tea, extracts in beverages, or as part of food (Safe intake level derived as 338 mg EGCG/day for solid bolus tea preparations; OSL 704 mg EGCG/day for beverage form)
Which population does the evidence apply to?
Most studies investigated: animal; unknown.
Are there safety considerations for Polyphenols?
• not reported • Hepatotoxicity was the critical adverse effect. • Risk was linked to concentrated catechin-rich products and large bolus doses. • Bolus gavage and fasting increased toxicity in toxicology evidence.

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