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Sleep LatencyEvidence & Dosage

Time from lying down to falling asleep — target ~15–20 min.

Studies last updated

Evidence at a glance

Total studies
557
With abstract
50
Meta / Systematic / RCT
157
Highly cited
25
Publication years
1986–2026

Sleep Latency in the context of Sleep

This topic is part of our "Sleep" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Sleep Latency

Ranked by influential-citation count and publication year.

  1. Comparative efficacy and safety of daridorexant, lemborexant, and suvorexant for insomnia: a systematic review and network meta-analysis.

    Transl Psychiatry2025n=5,198Meta-Analysis72 influential citations

    <h4>Background</h4>In order to appraise the risk-benefit balance of the three available dual orexin receptor antagonists (DORAs; daridorexant, lemborexant, and suvorexant) for the management of adults with insomnia, we conducted a…

  2. Clinical practice guidelines for switching or deprescribing hypnotic medications for chronic insomnia: Results of European neuropsychopharmacology and sleep expert's consensus group.

    Sleep Med2025n=21systematic71 influential citations

    INTRODUCTION: Current guidelines recommend cognitive behavioural therapy for insomnia (CBT-I) as the first-line treatment for chronic insomnia. Pharmacological recommendations by European guidelines for the treatment of insomnia disorder…

  3. Sleep quality and duration and frailty in older adults: a systematic review.

    Front Public Health2025n=58,447systematic63 influential citations

    INTRODUCTION: Sleep problems and frailty are associated with adverse health outcomes in older adults, including mortality, and constitute a major public health challenge. OBJECTIVE: This study investigated the association between sleep…

  4. Effects of sleep hygiene education for insomnia: A systematic review and meta-analysis.

    Sleep Med Rev2025n=424Meta-Analysis56 influential citations

    Sleep hygiene education (SHE) as a single therapy for insomnia still lacks sufficient evidence. This study aimed to quantify the effects of SHE on insomnia treatment. A literature search was conducted on seven databases from inception up…

  5. Effects of various exercise interventions in insomnia patients: a systematic review and network meta-analysis.

    BMJ Evid Based Med2026n=134meta50 influential citations

    OBJECTIVES: To compare the effectiveness of different exercise interventions in improving sleep quality and alleviating insomnia severity among patients with insomnia. DESIGN: Our study design was a systematic review and network…

  6. Relationships among sleep quality, anxiety, and depression among Chinese nurses: A network analysis.

    J Affect Disord2025n=711meta49 influential citations

    BACKGROUND: This study aimed to elucidate the symptom-symptom interactions of sleep quality, depression, and anxiety in Chinese nurses and to compare a multimorbidity group, a comorbidity group, and a healthy group via a network model.…

    Finding: Depressed affect was the most central symptom in the entire sample and in the multimorbidity group.

  7. Insomnia and emotion dysregulation: a meta-analytical perspective integrating regulatory strategies and dispositional difficulties.

    Sleep Med Rev2025Meta-Analysis44 influential citations

    Insomnia and emotion dysregulation are intricately related, yet their aggregate association across different domains of emotion dysregulation and the effect of moderating factors including health-related status, age, and gender remain…

  8. Association between insomnia symptoms and chronotype-A systematic review and meta-analysis.

    Sleep Health2025n=27,789Meta-Analysis41 influential citations

    <h4>Objectives</h4>This meta-analysis aimed to examine the association between chronotype and insomnia.<h4>Methods</h4>A systematic search of PubMed, Embase, and the Cochrane Library was conducted to identify prospective and…

  9. Sleep abnormalities in bipolar disorders across mood phases: A systematic review and meta-analysis.

    Sleep Med Rev2025n=7,614Meta-Analysis37 influential citations

    Sleep abnormalities are core features of bipolar disorders (BD), but they have not been thoroughly examined across mood phases. This meta-analysis investigated sleep disturbance prevalence and sleep characteristics differences in BD across…

    Finding: In this meta-analysis of bipolar disorder across mood phases, poor sleep quality was highly prevalent during euthymia, with a prevalence of 52%.

  10. Are sleep and awake bruxism associated with sleep quality and duration in adults? A systematic review and meta-analysis.

    Sleep Med2025n=470Meta-Analysis37 influential citations

    The objective of this systematic review was to investigate the association between sleep quality with awake bruxism or sleep bruxism in adult individuals. Inclusion criteria comprised observational studies conducted in adults related to…

Frequently asked

What dosage was studied?
• daridorexant, lemborexant, and suvorexant • Switching or deprescribing hypnotic medications; gradual discontinuation, cross-tapering to CBT-I, daridorexant, eszopiclone, or melatonin 2 mg PR (Dose reductions of 10-25% each week for hypnotic benzodiazepines and Z-drugs; melatonin 2 mg prolonged release; daridorexant not specified) • Sleep quality and duration assessment (Not applicable; exposures included poor sleep quality, insomnia, short/long sleep duration, sleep efficiency, latency, sleep disorders)
Which population does the evidence apply to?
Most studies investigated: unknown.
Are there safety considerations for Sleep Latency?
• Gradual dose reduction is advised for hypnotic benzodiazepines and Z-drugs. • Dose reductions of 10-25% per week are recommended to avoid abrupt stopping. • No adverse events were reported; this was a systematic review of observational studies. • Not reported

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