CaffeineEvidence & Dosage
Adenosine-receptor antagonist, tolerance, timing, half-life, genetics.
Evidence at a glance
- Total studies
- 1,000
- With abstract
- 50
- Meta / Systematic / RCT
- 7
- Highly cited
- 50
- Publication years
- 1957–2026
Caffeine in the context of Cognition
This topic is part of our "Cognition" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to CognitionTop studies on Caffeine
Ranked by influential-citation count and publication year.
Coffee and health: a review of recent human research.
Critical reviews in food science and nutrition2006180 influential citationsCoffee is a complex mixture of chemicals that provides significant amounts of chlorogenic acid and caffeine. Unfiltered coffee is a significant source of cafestol and kahweol, which are diterpenes that have been implicated in the…
Coffee consumption and risk of type 2 diabetes: a systematic review.
JAMA2005n=193129 influential citations<h4>Context</h4>Emerging epidemiological evidence suggests that higher coffee consumption may reduce the risk of type 2 diabetes.<h4>Objective</h4>To examine the association between habitual coffee consumption and risk of type 2 diabetes…
Effects of caffeine on the human circadian clock in vivo and in vitro.
Sci Transl Med2015rct83 influential citationsCaffeine's wakefulness-promoting and sleep-disrupting effects are well established, yet whether caffeine affects human circadian timing is unknown. We show that evening caffeine consumption delays the human circadian melatonin rhythm in…
The Effect of Post-Activation Potentiation Enhancement Alone or in Combination with Caffeine on Anaerobic Performance in Boxers: A Double-Blind, Randomized Crossover Study.
Nutrients202474 influential citationsPost-activation performance enhancement (PAPE) is a physiological phenomenon that refers to an acute excitation of the neuromuscular system following intense exercise that ends in enhanced physical performance in a subsequent bout of…
Caffeine use in children: what we know, what we have left to learn, and why we should worry.
Neuroscience and biobehavioral reviews200973 influential citationsCaffeine is a widely used psychoactive substance in both adults and children that is legal, easy to obtain, and socially acceptable to consume. Although once relatively restricted to use among adults, caffeine-containing drinks are now…
Acute effects of caffeine-containing energy drinks on physical performance: a systematic review and meta-analysis.
Eur J Nutr2017n=34Meta-Analysis69 influential citations<h4>Purpose</h4>Caffeine-containing energy drinks (EDs) are currently used as ergogenic aids to improve physical performance in a wide variety of sport disciplines. However, the outcomes of previous investigations on this topic are…
Coffee and caffeine intake and incidence of type 2 diabetes mellitus: a meta-analysis of prospective studies.
European journal of nutrition201463 influential citations<h4>Purpose</h4>Coffee and caffeine have been linked to type 2 diabetes mellitus (T2DM). A dose-response meta-analysis of prospective studies was conducted to assess the association between coffee and caffeine intake and T2DM…
Variations in caffeine and chlorogenic acid contents of coffees: what are we drinking?
Food & function201463 influential citationsThe effect of roasting of coffee beans and the extraction of ground coffee with different volumes of hot pressurised water on the caffeine and the total caffeoylquinic acids (CQAs) content of the resultant beverages was investigated. While…
The effects of caffeine on bone mineral density and fracture risk.
Osteoporos Int2022other59 influential citationsCaffeine is a regular part of the diet of many adults (coffee, tea, soft drinks, and energy drinks). Multiple molecular effects of caffeine suggest that it may promote bone loss. Given the extensive consumption of caffeine worldwide, any…
Separate and combined effects of the social drugs on psychomotor performance.
Psychopharmacology199155 influential citationsTen female subjects (five smokers and five non-smokers) performed a choice reaction time task (CRT), a compensatory tracking task (CTT), a short-term memory task (STM) and were tested for their critical flicker fusion threshold (CFF) at…
Frequently asked
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I'm interested in products that can boost my mental performance
Mental performance follows a hierarchy: sleep quality > regular strength training > omega-3 (DHA) > creatine (under sleep deprivation) > caffeine (acute). 'Cognitive enhancer' supplements like lion's mane, bacopa, and nootropic stacks have much weaker evidence and are practically dominated by the effect of a well-regulated sleep.
Which self-optimization products do you recommend for more energy and focus?
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