Dopamine DetoxEvidence & Dosage
A popular trend without strong scientific backing — what still holds up.
Evidence at a glance
- Total studies
- 209
- With abstract
- 50
- Meta / Systematic / RCT
- 1
- Highly cited
- 50
- Publication years
- 1985–2026
Dopamine Detox in the context of Cognition
This topic is part of our "Cognition" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to CognitionTop studies on Dopamine Detox
Ranked by influential-citation count and publication year.
Neural mechanisms of addiction: the role of reward-related learning and memory.
Annual review of neuroscience2006200 influential citationsAddiction is a state of compulsive drug use; despite treatment and other attempts to control drug taking, addiction tends to persist. Clinical and laboratory observations have converged on the hypothesis that addiction represents the…
The neural basis of addiction: a pathology of motivation and choice.
The American journal of psychiatry2005200 influential citations<h4>Objective</h4>A primary behavioral pathology in drug addiction is the overpowering motivational strength and decreased ability to control the desire to obtain drugs. In this review the authors explore how advances in neurobiology are…
Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex.
The American journal of psychiatry2002200 influential citations<h4>Objective</h4>Studies of the neurobiological processes underlying drug addiction primarily have focused on limbic subcortical structures. Here the authors evaluated the role of frontal cortical structures in drug…
Addiction motivation reformulated: an affective processing model of negative reinforcement.
Psychological review2004200 influential citationsThis article offers a reformulation of the negative reinforcement model of drug addiction and proposes that the escape and avoidance of negative affect is the prepotent motive for addictive drug use. The authors posit that negative affect…
The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence.
The American journal of psychiatry1985200 influential citationsRecent clinical observations and psychiatric diagnostic findings of drug-dependent individuals suggest that they are predisposed to addiction because they suffer with painful affect states and related psychiatric disorders. The drugs that…
Impulsivity as a vulnerability marker for substance-use disorders: review of findings from high-risk research, problem gamblers and genetic association studies.
Neuroscience and biobehavioral reviews2008200 influential citationsThere is a longstanding association between substance-use disorders (SUDs) and the psychological construct of impulsivity. In the first section of this review, personality and neurocognitive data pertaining to impulsivity will be…
Addiction and the brain antireward system.
Annual review of psychology2008200 influential citationsA neurobiological model of the brain emotional systems has been proposed to explain the persistent changes in motivation that are associated with vulnerability to relapse in addiction, and this model may generalize to other psychopathology…
Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex.
Cerebral cortex (New York, N.Y. : 1991)2000200 influential citationsUnderstanding the changes in the brain which occur in the transition from normal to addictive behavior has major implications in public health. Here we postulate that while reward circuits (nucleus accumbens, amygdala), which have been…
A role for brain stress systems in addiction.
Neuron2008200 influential citationsDrug addiction is a chronically relapsing disorder characterized by compulsion to seek and take drugs and has been linked to dysregulation of brain regions that mediate reward and stress. Activation of brain stress systems is hypothesized…
Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On.
Annual review of psychology2016200 influential citationsA decade ago, we hypothesized that drug addiction can be viewed as a transition from voluntary, recreational drug use to compulsive drug-seeking habits, neurally underpinned by a transition from prefrontal cortical to striatal control over…
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