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Cognition

AcetylcholineEvidence & Dosage

Memory, attention, REM sleep, choline sources.

Evidence at a glance

Total studies
1,000
With abstract
43
Meta / Systematic / RCT
0
Highly cited
0
Publication years
1929–2026

Acetylcholine in the context of Cognition

This topic is part of our "Cognition" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Acetylcholine

Ranked by influential-citation count and publication year.

  1. Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation.

    Nature2003

    Excessive inflammation and tumour-necrosis factor (TNF) synthesis cause morbidity and mortality in diverse human diseases including endotoxaemia, sepsis, rheumatoid arthritis and inflammatory bowel disease. Highly conserved, endogenous…

  2. Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries

    New England Journal of Medicine1986

    Acetylcholine is believed to dilate normal blood vessels by promoting the release of a vasorelaxant substance from the endothelium (endothelium-derived relaxing factor). By contrast, if the endothelium is removed experimentally,…

  3. Efficacy of Varenicline, an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist, vs Placebo or Sustained-Release Bupropion for Smoking Cessation<SUBTITLE>A Randomized Controlled Trial</SUBTITLE>

    JAMA2006n=1,027

    <h4>Context</h4>Varenicline, a partial agonist at the alpha4beta2 nicotinic acetylcholine receptor, has the potential to aid smoking cessation by relieving nicotine withdrawal symptoms and reducing the rewarding properties of…

  4. Refined Structure of the Nicotinic Acetylcholine Receptor at 4Å Resolution

    Journal of Molecular Biology2004

    We present a refined model of the membrane-associated Torpedo acetylcholine (ACh) receptor at 4A resolution. An improved experimental density map was obtained from 342 electron images of helical tubes, and the refined structure was derived…

  5. Identification of a Family of Muscarinic Acetylcholine Receptor Genes

    Science1987

    Complementary DNAs for three different muscarinic acetylcholine receptors were isolated from a rat cerebral cortex library, and the cloned receptors were expressed in mammalian cells. Analysis of human and rat genomic clones indicates that…

  6. Varenicline, an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist, vs Sustained-Release Bupropion and Placebo for Smoking Cessation&lt;SUBTITLE&gt;A Randomized Controlled Trial&lt;/SUBTITLE&gt;

    JAMA2006n=1,025

    <h4>Context</h4>The alpha4beta2 nicotinic acetylcholine receptors (nAChRs) are linked to the reinforcing effects of nicotine and maintaining smoking behavior. Varenicline, a novel alpha4beta2 nAChR partial agonist, may be beneficial for…

  7. Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine

    Nature1998

    Release of the neurotransmitter dopamine in the mesolimbic system of the brain mediates the reinforcing properties of several drugs of abuse, including nicotine. Here we investigate the contribution of the high-affinity neuronal nicotinic…

  8. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

    Nature2008

    Lung cancer is the most common cause of cancer death worldwide, with over one million cases annually. To identify genetic factors that modify disease risk, we conducted a genome-wide association study by analysing 317,139 single-nucleotide…

  9. Structure and gating mechanism of the acetylcholine receptor pore

    Nature2003

    The nicotinic acetylcholine receptor controls electrical signalling between nerve and muscle cells by opening and closing a gated, membrane-spanning pore. Here we present an atomic model of the closed pore, obtained by electron microscopy…

  10. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease.

    Circulation1990n=34

    In animals, acetylcholine dilates normal arteries and produces vasoconstriction in the presence of hypercholesterolemia, hypertension, or atherosclerosis, reflecting endothelial cell dysfunction. In patients with angiographically smooth…

Frequently asked

Are there safety considerations for Acetylcholine?
• Treatment was discontinued due to adverse events by 10.5% of participants in the varenicline group, 12.6% in the bupropion SR group, and 7.3% in the placebo group. • Varenicline was safe and generally well tolerated, with study drug discontinuation rates similar to those for placebo.

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